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    Reverse-turn mimetics and method relating thereto
    21.
    发明授权
    Reverse-turn mimetics and method relating thereto 有权
    反转模拟物及其相关方法

    公开(公告)号：US08138337B2

    公开(公告)日：2012-03-20

    申请号：US12649161

    申请日：2009-12-29

    Applicant: Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen ,  Soo Jin Lee

    Inventor： Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen ,  Soo Jin Lee

    IPC: C07D487/04 ,  A61K31/53 ,  A61P19/02 ,  A61P35/00

    CPC classification number: C07D487/04 ,  A61K31/53

    Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins as well as their prodrugs are disclosed. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds and prodrugs for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

    Abstract translation: 公开了模拟生物活性肽和蛋白质的逆转转区域的二级结构及其前药的构象约束化合物。 这种反转模拟结构和前药在广泛的领域中具有实用性，包括用作诊断和治疗剂。 还公开了包含本发明的反转模拟结构的文库以及用于筛选其的方法以鉴定生物活性成员。 本发明还涉及这些化合物和前药用于抑制或治疗由Wnt信号传导途径调节的疾病如癌症，特别是结肠直肠癌，与血管成形术相关的再狭窄，多囊肾病，异常血管生成疾病，类风湿性关节炎疾病，结节性 硬化综合征，阿尔茨海默氏病，过度头发生长或损失，或溃疡性结肠炎。

    Reverse-turn mimetics and method relating thereto
    22.
    发明授权
    Reverse-turn mimetics and method relating thereto 有权
    反转模拟物及其相关方法

    公开(公告)号：US07932384B2

    公开(公告)日：2011-04-26

    申请号：US12510107

    申请日：2009-07-27

    Applicant: Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen ,  Soo Jin Lee

    Inventor： Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen ,  Soo Jin Lee

    IPC: C07D487/04 ,  A61K31/53 ,  A61P19/02 ,  A61P35/00

    CPC classification number: C07D487/04 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/53 ,  A61K31/555 ,  A61K45/06 ,  A61K2300/00

    Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

    Abstract translation: 公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。 这种反转模拟结构在广泛的领域中具有实用性，包括用作诊断和治疗剂。 还公开了包含本发明的反转模拟结构的文库以及用于筛选其的方法以鉴定生物活性成员。 本发明还涉及这种化合物用于抑制或治疗由Wnt信号传导途径调节的疾病，例如癌症，特别是结肠直肠癌，与血管成形术，多囊肾病，异常血管生成疾病，类风湿性关节炎疾病，结节性硬化综合征相关的再狭窄 ，阿尔茨海默氏病，过度毛发生长或损失，或溃疡性结肠炎。

    Apparatus and method for verifying update data in mobile communication system
    27.
    发明授权
    Apparatus and method for verifying update data in mobile communication system 有权
    用于在移动通信系统中验证更新数据的装置和方法

    公开(公告)号：US07987324B2

    公开(公告)日：2011-07-26

    申请号：US11874658

    申请日：2007-10-18

    Applicant: Sung-Chan Lee

    Inventor： Sung-Chan Lee

    IPC: G06F12/00 ,  G06F13/00 ,  G06F13/28

    CPC classification number: G06F3/0643 ,  G06F3/0619 ,  G06F3/0632 ,  G06F3/0673 ,  G06F3/0679 ,  G11B27/329 ,  G11B27/36

    Abstract: Provided is an apparatus and method for searching update data of an external memory. The apparatus includes the detachable external memory, a data management unit, and a controller. The detachable external memory stores a File Allocation Table (FAT) and a plurality of pieces of data. The data management unit updates a first FAT and creates a second FAT having the same information as the first FAT. The controller controls the data management unit to access the requested data, update information on the first FAT, and create the second FAT.

    Abstract translation: 提供了一种用于搜索外部存储器的更新数据的装置和方法。 该装置包括可拆卸的外部存储器，数据管理单元和控制器。 可拆卸外部存储器存储文件分配表（FAT）和多条数据。 数据管理单元更新第一FAT并创建具有与第一FAT相同信息的第二FAT。 控制器控制数据管理单元访问所请求的数据，更新关于第一FAT的信息，并创建第二FAT。

    METHOD FOR RECOGNIZING TOUCH INPUT IN TOUCH SCREEN BASED DEVICE
    28.
    发明申请
    METHOD FOR RECOGNIZING TOUCH INPUT IN TOUCH SCREEN BASED DEVICE 审中-公开
    用于基于触摸屏的设备识别触摸输入的方法

    公开(公告)号：US20100315366A1

    公开(公告)日：2010-12-16

    申请号：US12813703

    申请日：2010-06-11

    Applicant: Sung Chan LEE ,  Hyun Su KIM ,  Young Soo YUN ,  Soo Hyeon LEE

    Inventor： Sung Chan LEE ,  Hyun Su KIM ,  Young Soo YUN ,  Soo Hyeon LEE

    IPC: G06F3/041

    CPC classification number: G06F3/04886 ,  A63F2300/1075 ,  G06F3/0486 ,  G06F3/04883

    Abstract: A method for recognizing touch input in a touch screen based device is provided. The method for recognizing touch includes: checking a location of the touch input when a touch is inputted; checking a changed location of the touch when a location of the touch is changed; and recognizing that the touch is released in the location of the touch input when touch release occurs in the changed location.

    Abstract translation: 提供了一种用于识别基于触摸屏的设备中的触摸输入的方法。 用于识别触摸的方法包括：当输入触摸时检查触摸输入的位置; 当触摸的位置改变时检查触摸的改变的位置; 并且识别当在改变的位置发生触摸释放时触摸被释放在触摸输入的位置。

    REVERSE-TURN MIMETICS AND METHOD RELATING THERETO
    29.
    发明申请
    REVERSE-TURN MIMETICS AND METHOD RELATING THERETO 有权
    反向转换和相关的方法

    公开(公告)号：US20100081655A1

    公开(公告)日：2010-04-01

    申请号：US12541388

    申请日：2009-08-14

    Applicant: Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen

    Inventor： Sung Hwan Moon ,  Jae Uk Chung ,  Sung Chan Lee ,  Masakatsu Eguchi ,  Michael Kahn ,  Kwang Won Jeong ,  Cu Nguyen

    IPC: A61K31/53 ,  C07D487/04 ,  A61K31/538 ,  A61K31/5377

    CPC classification number: C07D487/04 ,  A61K31/4985 ,  Y02A50/467

    Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.

    Abstract translation: 公开了模拟生物活性肽和蛋白质的反转转区的二级结构的构象约束化合物。 这种反转模拟结构在广泛的领域中具有实用性，包括用作诊断和治疗剂。 还公开了包含本发明的反转模拟结构的文库以及用于筛选其的方法以鉴定生物活性成员。 本发明还涉及这种化合物用于抑制或治疗由Wnt信号传导途径调节的疾病，例如癌症，特别是结肠直肠癌，与血管成形术，多囊肾病，异常血管生成疾病，类风湿性关节炎疾病，结节性硬化综合征相关的再狭窄 ，阿尔茨海默氏病，过度毛发生长或损失，或溃疡性结肠炎。

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