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公开(公告)号：US20160367527A1
公开(公告)日：2016-12-22
申请号：US14886938
申请日：2015-10-19
Applicant: DONALD J. ZACK , THOMAS BANNISTER , TOMAS VOJKOVSKY , ZHIYONG YANG , CYNTHIA BERLINICKE
Inventor： DONALD J. ZACK , THOMAS BANNISTER , TOMAS VOJKOVSKY , ZHIYONG YANG , CYNTHIA BERLINICKE
IPC: A61K31/404 , C07D403/06 , A61K45/06
CPC classification number: A61K31/404 , A61K31/439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D209/34 , C07D403/06 , C07D403/14 , C07D453/02 , C07D495/04 , A61K2300/00
Abstract: Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.
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22.发明授权3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors 失效3-（4-氨基吡咯-2-基亚甲基）-2-二氢吲哚酮衍生物作为蛋白激酶抑制剂公开(公告)号：US07582756B2
公开(公告)日：2009-09-01
申请号：US11779807
申请日：2007-07-18
Applicant: Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu Jin , Paul M. Herrinton , Michael A. Mauragis
Inventor： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu Jin , Paul M. Herrinton , Michael A. Mauragis
IPC: C07D413/14
CPC classification number: C07D403/06 , C07D403/14 , C07D471/04
Abstract: The present invention provides a method to make a pyrrole substituted 2-indolinone compound of the formula
Abstract translation: 本发明提供了制备下式的吡咯取代的2-二氢吲哚酮化合物的方法
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公开(公告)号：US20080242644A1
公开(公告)日：2008-10-02
申请号：US11597334
申请日：2005-06-02
Applicant: Steven M. Torkelson , Tomas Vojkovsky
Inventor： Steven M. Torkelson , Tomas Vojkovsky
IPC: A61K31/4184 , C07D235/04 , A61K31/4436 , A61K31/60 , A61P7/02
CPC classification number: C07D235/18
Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
Abstract translation: 本发明涉及因子VIIa，IXa，Xa，XIa，特别是因子VIIa的新型抑制剂，包含这些抑制剂的药物组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病，癌症或类风湿性关节炎的方法。 还公开了制备这些抑制剂的方法。
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Patent Agency Ranking
24.发明授权3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone der derivatives as protein kinase inhibitors 失效3-（4-氨基吡咯-2-基亚甲基）-2-二氢吲哚衍生物作为蛋白激酶抑制剂公开(公告)号：US07256189B2
公开(公告)日：2007-08-14
申请号：US11511981
申请日：2006-08-28
Applicant: Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu (Alan) Jin , Paul M. Herrinton , Michael A. Mauragis
Inventor： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu (Alan) Jin , Paul M. Herrinton , Michael A. Mauragis
IPC: A61K31/5377 , C07D413/14
CPC classification number: C07D403/06 , C07D403/14 , C07D471/04
Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
Abstract translation: 本发明涉及吡咯取代的2-二氢吲哚酮化合物及其药学上可接受的盐，其调节蛋白激酶的活性，因此预期可用于预防和治疗与蛋白激酶相关的细胞病症例如癌症。
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25.发明授权3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors 失效3-（4-氨基吡咯-2-基亚甲基）-2-二氢吲哚酮衍生物作为蛋白激酶抑制剂公开(公告)号：US07179910B2
公开(公告)日：2007-02-20
申请号：US10656907
申请日：2003-09-08
Applicant: Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu (Alan) Jin , Paul M. Herrinton , Michael A. Mauragis
Inventor： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu (Alan) Jin , Paul M. Herrinton , Michael A. Mauragis
IPC: C07D279/12 , C07D413/14 , C07D209/34 , C07D249/02 , C07D257/04 , C07D403/14
CPC classification number: C07D403/06 , C07D403/14 , C07D471/04
Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
Abstract translation: 本发明涉及吡咯取代的2-二氢吲哚酮化合物及其药学上可接受的盐，其调节蛋白激酶的活性，因此预期可用于预防和治疗与蛋白激酶相关的细胞病症例如癌症。
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公开(公告)号：US20060009493A1
公开(公告)日：2006-01-12
申请号：US10875508
申请日：2004-06-25
Applicant: Marcel Koenig , Jingrong Cui , Chung Wei , Steven Do , Fang-Jie Zhang , Tomas Vojkovsky , John Ramphal , Guang Yang , Matthew Mattson , Christopher Nelson , Peng Tang
Inventor： Marcel Koenig , Jingrong Cui , Chung Wei , Steven Do , Fang-Jie Zhang , Tomas Vojkovsky , John Ramphal , Guang Yang , Matthew Mattson , Christopher Nelson , Peng Tang
IPC: C07D43/02 , A61K31/4439
CPC classification number: C07D209/40 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D471/04
Abstract: The present invention relates to compounds of the formulae (I)-(XII), wherein R1-R71, A, B, X, Y, G, L and Z are defined herein, and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as cancer.
Abstract translation: 本发明涉及式（I） - （XII）的化合物，其中R 1 -R 71，A，B，X，Y，G，L和 Z在本文中定义，及其药学上可接受的盐。 这些化合物调节c-Met的活性，因此预期可用于预防和治疗c-Met相关疾病如癌症。
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27.发明授权公开(公告)号：US06797725B2
公开(公告)日：2004-09-28
申请号：US10118321
申请日：2002-04-09
Applicant: Connie Li Sun , Chung Chen Wei , Peng Cho Tang , Marcel Koenig , Yong Zhou , Tomas Vojkovsky , Asaad S. Nematalla
Inventor： Connie Li Sun , Chung Chen Wei , Peng Cho Tang , Marcel Koenig , Yong Zhou , Tomas Vojkovsky , Asaad S. Nematalla
IPC: A61K31403
CPC classification number: C07D403/06 , C07D403/14 , C07F9/5728 , C07F9/65583 , C07H15/26
Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
Abstract translation: 本发明涉及吡咯取代的2-二氢吲哚酮化合物及其药学上可接受的盐，其调节蛋白激酶的活性，因此预期可用于预防和治疗与蛋白激酶相关的细胞病症例如癌症。
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28.发明授权3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors 失效3-（4-氨基吡咯-2-基亚甲基）-2-二氢吲哚酮衍生物作为蛋白激酶抑制剂公开(公告)号：US06653308B2
公开(公告)日：2003-11-25
申请号：US10076140
申请日：2002-02-15
Applicant: Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu Jin , Paul M. Herrinton , Michael A. Mauragis
Inventor： Huiping Guan , Congxin Liang , Li Sun , Peng Cho Tang , Chung Chen Wei , Tomas Vojkovsky , Qingwu Jin , Paul M. Herrinton , Michael A. Mauragis
IPC: A61K31404
CPC classification number: C07D403/06 , C07D403/14 , C07D471/04
Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
Abstract translation: 本发明涉及吡咯取代的2-二氢吲哚酮化合物及其药学上可接受的盐，其调节蛋白激酶的活性，因此预期可用于预防和治疗与蛋白激酶相关的细胞病症例如癌症。
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