公开(公告)号：US07053114B2

公开(公告)日：2006-05-30

申请号：US10816957

申请日：2004-04-05

Applicant: Connie Li Sun ,  Chung Chen Wei ,  Peng Cho Tang ,  Marcel Koenig ,  Yong Zhou ,  Tomas Vojkovsky ,  Asaad S. Nematalla

Inventor： Connie Li Sun ,  Chung Chen Wei ,  Peng Cho Tang ,  Marcel Koenig ,  Yong Zhou ,  Tomas Vojkovsky ,  Asaad S. Nematalla

IPC: A61K31/403 ,  C07D233/02 ,  A61P35/00

CPC classification number: C07D403/06 ,  C07D403/14 ,  C07F9/5728 ,  C07F9/65583 ,  C07H15/26

Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

公开(公告)号：US06642232B2

公开(公告)日：2003-11-04

申请号：US10268082

申请日：2002-10-10

Applicant: Matthew Mattson ,  Tomas Vojkovsky ,  Congxin Liang ,  Peng Cho Tang ,  Huiping Guan

Inventor： Matthew Mattson ,  Tomas Vojkovsky ,  Congxin Liang ,  Peng Cho Tang ,  Huiping Guan

IPC: A61K315377

CPC classification number: C07D401/14 ,  C07D403/12 ,  C07D403/14

Abstract: The present invention relates to certain 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives that inhibit kinases, in particular VEGFR and/or PDGFR kinases. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.

公开(公告)号：US09162981B2

公开(公告)日：2015-10-20

申请号：US13636415

申请日：2011-03-23

Applicant: Donald J. Zack ,  Thomas Bannister ,  Tomas Vojkovsky ,  Zhiyong Yang ,  Cynthia Berlinicke

Inventor： Donald J. Zack ,  Thomas Bannister ,  Tomas Vojkovsky ,  Zhiyong Yang ,  Cynthia Berlinicke

IPC: C07D209/34 ,  A61K31/55 ,  A61K31/454 ,  A61K31/496 ,  A61K31/439 ,  A61K45/06 ,  A61K31/404 ,  A61K31/5377 ,  C07D403/06 ,  C07D453/02 ,  C07D403/14 ,  C07D495/04

CPC classification number: A61K31/404 ,  A61K31/439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D209/34 ,  C07D403/06 ,  C07D403/14 ,  C07D453/02 ,  C07D495/04 ,  A61K2300/00

Abstract: Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.

Abstract translation: 公开了用于治疗与神经变性或眼部疾病相关的病症的化合物，组合物，试剂盒和方法。

公开(公告)号：US07572924B2

公开(公告)日：2009-08-11

申请号：US11517529

申请日：2006-09-06

Applicant: Peng Cho Tang ,  Todd Anthony Miller ,  Xiaoyuan Li ,  Connie Li Sun ,  Chung Chen Wei ,  Shahrzad Shirazian ,  Congxin Liang ,  Tomas Vojkovsky ,  Asaad S. Nematalla ,  Michael Hawley

Inventor： Peng Cho Tang ,  Todd Anthony Miller ,  Xiaoyuan Li ,  Connie Li Sun ,  Chung Chen Wei ,  Shahrzad Shirazian ,  Congxin Liang ,  Tomas Vojkovsky ,  Asaad S. Nematalla ,  Michael Hawley

IPC: A61K31/404 ,  C07D403/06

CPC classification number: C07D233/56 ,  C07D207/33 ,  C07D209/44 ,  C07D231/12 ,  C07D249/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14

Abstract: The present invention relates to pyrrole substituted-2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Abstract translation: 本发明涉及吡咯取代-2-二氢吲哚酮化合物及其药学上可接受的盐，其调节蛋白激酶的活性，因此预期可用于预防和治疗与蛋白激酶相关的细胞病症例如癌症。

公开(公告)号：US20080045709A1

公开(公告)日：2008-02-21

申请号：US11779807

申请日：2007-07-18

Applicant: Huiping Guan ,  Congxin Liang ,  Li Sun ,  Peng Cho Tang ,  Chung Wei ,  Tomas Vojkovsky ,  Qingwu Jin ,  Paul Herrinton ,  Michael Mauragis

Inventor： Huiping Guan ,  Congxin Liang ,  Li Sun ,  Peng Cho Tang ,  Chung Wei ,  Tomas Vojkovsky ,  Qingwu Jin ,  Paul Herrinton ,  Michael Mauragis

IPC: C07D413/14

CPC classification number: C07D403/06 ,  C07D403/14 ,  C07D471/04

Abstract: The present invention provides a method to make a pyrrole substituted 2-indolinone compound of the formula

Abstract translation: 本发明提供了制备下式的吡咯取代的2-二氢吲哚酮化合物的方法

公开(公告)号：US07125905B2

公开(公告)日：2006-10-24

申请号：US11028477

申请日：2005-01-04

Applicant: Peng Cho Tang ,  Todd A. Miller ,  Xiaoyuan Li ,  Li Sun ,  Chung Chen Wei ,  Shahrzad Shirazian ,  Congxin Liang ,  Tomas Vojkovsky ,  Asaad S. Nematalla ,  Michael Hawley

Inventor： Peng Cho Tang ,  Todd A. Miller ,  Xiaoyuan Li ,  Li Sun ,  Chung Chen Wei ,  Shahrzad Shirazian ,  Congxin Liang ,  Tomas Vojkovsky ,  Asaad S. Nematalla ,  Michael Hawley

IPC: A61K31/404 ,  C07D403/06

CPC classification number: C07D233/56 ,  C07D207/33 ,  C07D209/44 ,  C07D231/12 ,  C07D249/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14

Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

公开(公告)号：US20050075340A1

公开(公告)日：2005-04-07

申请号：US10874743

申请日：2004-06-24

Applicant: Fang-Jie Zhang ,  Tomas Vojkovsky ,  Ping Huang ,  Congxin Liang ,  Steven Do ,  Marcel Koenig ,  Jingrong Cui

Inventor： Fang-Jie Zhang ,  Tomas Vojkovsky ,  Ping Huang ,  Congxin Liang ,  Steven Do ,  Marcel Koenig ,  Jingrong Cui

IPC: A61P35/00 ,  C07D487/04 ,  A61K31/53

CPC classification number: C07D487/04

Abstract: The present invention relates to compounds of the Formula (I), and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as cancer.

Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐。 这些化合物调节c-Met的活性，因此预期可用于预防和治疗c-Met相关疾病如癌症。

公开(公告)号：US06573293B2

公开(公告)日：2003-06-03

申请号：US09783264

申请日：2001-02-15

Applicant: Peng Cho Tang ,  Todd A. Miller ,  Xiaoyuan Li ,  Li Sun ,  Chung Chen Wei ,  Shahrzad Shirazian ,  Congxin Liang ,  Tomas Vojkovsky ,  Asaad S. Nematalla ,  Michael Hawley

Inventor： Peng Cho Tang ,  Todd A. Miller ,  Xiaoyuan Li ,  Li Sun ,  Chung Chen Wei ,  Shahrzad Shirazian ,  Congxin Liang ,  Tomas Vojkovsky ,  Asaad S. Nematalla ,  Michael Hawley

IPC: A61K31404

CPC classification number: C07D233/56 ,  C07D207/33 ,  C07D209/44 ,  C07D231/12 ,  C07D249/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14

Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

公开(公告)号：US09539239B1

公开(公告)日：2017-01-10

申请号：US14886938

申请日：2015-10-19

Applicant: Donald Jeffrey Zack ,  Thomas Bannister ,  Tomas Vojkovsky ,  Zhiyong Yang ,  Cynthia Berlinicke

Inventor： Donald Jeffrey Zack ,  Thomas Bannister ,  Tomas Vojkovsky ,  Zhiyong Yang ,  Cynthia Berlinicke

IPC: A61K9/00 ,  A61K31/404 ,  A61K45/06 ,  C07D403/06

CPC classification number: A61K31/404 ,  A61K31/439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D209/34 ,  C07D403/06 ,  C07D403/14 ,  C07D453/02 ,  C07D495/04 ,  A61K2300/00

Abstract: Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.

Abstract translation: 公开了用于治疗与神经变性或眼部疾病相关的病症的化合物，组合物，试剂盒和方法。

公开(公告)号：US09382229B2

公开(公告)日：2016-07-05

申请号：US13985702

申请日：2012-02-15

Applicant: Donald J. Zack ,  Cynthia Berlinicke ,  Laszlo Hackler ,  Zhiyong Yang ,  Joseph P. Steiner ,  Tomas Vojkovsky ,  Dana Ferraris ,  Barbara S. Slusher ,  James Inglese

Inventor： Donald J. Zack ,  Cynthia Berlinicke ,  Laszlo Hackler ,  Zhiyong Yang ,  Joseph P. Steiner ,  Tomas Vojkovsky ,  Dana Ferraris ,  Barbara S. Slusher ,  James Inglese

IPC: C07D403/12 ,  C07D401/14 ,  C07D403/14 ,  C07D453/02

CPC classification number: C07D403/12 ,  C07D401/14 ,  C07D403/14 ,  C07D453/02

Abstract: Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.

Abstract translation: 公开了用于治疗与神经变性或眼部疾病相关的病症的化合物，组合物，试剂盒和方法。