公开(公告)号：US20080057102A1

公开(公告)日：2008-03-06

申请号：US11839104

申请日：2007-08-15

Applicant: Wouter Roorda

Inventor： Wouter Roorda

IPC: A61F2/02 ,  A61F2/82 ,  A61P39/00 ,  A61P41/00

CPC classification number: A61K31/436 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/608 ,  B22F3/008 ,  B22F3/105 ,  B22F2003/1051 ,  B22F2003/1054

Abstract: The present invention is a medical device for controlling the release of an active agent. The medical device has a supporting structure having a porous body disposed therein. At least one elution rate controlling matrix containing an effective amount of at least one active agent is disposed within the pores of the porous body in a manner that protects the matrix from mechanical damage. The medical device may therefore be used for controlled drug release applications. Additionally, the present invention discloses a method for using the medical device for the treatment and prevention of diseases in mammals. This invention further relates to a method for using the medical device for treating and preventing vascular diseases.

Abstract translation: 本发明是用于控制活性剂释放的医疗装置。 医疗器具具有设置在其中的多孔体的支撑结构。 含有有效量的至少一种活性剂的至少一种洗脱速率控制基质以保护基质免受机械损伤的方式设置在多孔体的孔内。 因此，医疗装置可用于受控药物释放应用。 另外，本发明公开了一种使用该医疗装置来治疗和预防哺乳动物疾病的方法。 本发明还涉及一种用于治疗和预防血管疾病的医疗装置的方法。

公开(公告)号：US20080057101A1

公开(公告)日：2008-03-06

申请号：US11839093

申请日：2007-08-15

Applicant: Wouter Roorda

Inventor： Wouter Roorda

IPC: A61K9/00 ,  A61K31/436

CPC classification number: A61K31/436 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/608 ,  B22F3/008 ,  B22F3/105 ,  B22F2003/1051 ,  B22F2003/1054

Abstract: The present invention is a medical device for controlling the release of an active agent. The medical device has a supporting structure having a porous body disposed therein. At least one elution rate controlling matrix containing an effective amount of at least one active agent is disposed within the pores of the porous body in a manner that protects the matrix from mechanical damage. The medical device may therefore be used for controlled drug release applications. Additionally, the present invention discloses a method for using the medical device for the treatment and prevention of diseases in mammals. This invention further relates to a method for using the medical device for treating and preventing vascular diseases.

Abstract translation: 本发明是用于控制活性剂释放的医疗装置。 医疗器具具有设置在其中的多孔体的支撑结构。 含有有效量的至少一种活性剂的至少一种洗脱速率控制基质以保护基质免受机械损伤的方式设置在多孔体的孔内。 因此，医疗装置可用于受控药物释放应用。 另外，本发明公开了一种使用该医疗装置来治疗和预防哺乳动物疾病的方法。 本发明还涉及一种用于治疗和预防血管疾病的医疗装置的方法。

公开(公告)号：US20070059434A1

公开(公告)日：2007-03-15

申请号：US11592632

申请日：2006-11-02

Applicant: Wouter Roorda ,  Syed Hossainy ,  Ni Ding ,  Fuh-Wei Tang ,  Stephen Pacetti

Inventor： Wouter Roorda ,  Syed Hossainy ,  Ni Ding ,  Fuh-Wei Tang ,  Stephen Pacetti

IPC: A61L33/00 ,  B05D3/00

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02 ,  A61L2420/08

Abstract: A method of coating an implantable medical device, such as a stent, is disclosed. The method includes applying a formulation on a first polymer layer containing a therapeutic substance to form a second layer. The formulation can contain a highly hydrophobic polymer or a solvent which is a poor solvent for the drug or the polymer of the first layer. The formulation can have a low surface tension value or a high Weber number value.

公开(公告)号：US20060002974A1

公开(公告)日：2006-01-05

申请号：US11212376

申请日：2005-08-26

Applicant: Stephen Pacetti ,  Eugene Michal ,  Syed Hossainy ,  Ni Ding ,  Wouter Roorda

Inventor： Stephen Pacetti ,  Eugene Michal ,  Syed Hossainy ,  Ni Ding ,  Wouter Roorda

IPC: A61K31/737 ,  A61K31/727 ,  A61K31/728 ,  A61F2/00

CPC classification number: A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61L31/10 ,  C08L89/00

Abstract: Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.