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    Methods for manufacturing amino acid mimetic copolymers and use of same
    2.
    发明授权
    Methods for manufacturing amino acid mimetic copolymers and use of same 失效
    制备氨基酸模拟共聚物的方法及其用途

    公开(公告)号：US08658749B2

    公开(公告)日：2014-02-25

    申请号：US12575720

    申请日：2009-10-08

    申请人： Stephen Pacetti

    发明人： Stephen Pacetti

    IPC分类号： C08F220/48 ,  C08F220/06 ,  C08F118/02 ,  C08F20/70

    CPC分类号： A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L27/18

    摘要： Biocompatible polymers are manufactured to include an ammo acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties.

    摘要翻译： 制备生物相容性聚合物以包含氨基酸模拟单体和一种或多种疏水性丙烯酸酯单体。 选择氨基酸模拟单体以模拟氨基酸天冬酰胺或谷氨酰胺的侧链。 氨基酸模拟单体可以是2-羟基乙酰胺，3-羟基丙酰胺，丙烯酰胺，乳酰胺或甘氨酰胺的甲基丙烯酰基或丙烯酰基衍生物。 这些酰胺官能团具有中等的亲水性，几乎没有化学反应性的优点。 氨基酸模拟单体可以与一种或多种疏水丙烯酸酯单体共聚以获得所需的涂料性质。

    RADIOPAQUE INTRALUMINAL STENT
    3.
    发明申请
    RADIOPAQUE INTRALUMINAL STENT 有权
    放射性胸腔镜

    公开(公告)号：US20130013055A1

    公开(公告)日：2013-01-10

    申请号：US13618602

    申请日：2012-09-14

    申请人： Stephen Pacetti ,  Pamela A. Kramer

    发明人： Stephen Pacetti ,  Pamela A. Kramer

    IPC分类号： A61F2/86

    CPC分类号： A61L31/18 ,  A61F2/91 ,  A61F2/92 ,  A61L31/022

    摘要： The present invention includes a radiopaque stent comprising a cylindrical main body. The tubular main body comprises a cobalt chromium alloy that comprises cobalt, chromium and one or more radiopaque materials.

    摘要翻译： 本发明包括一种包括圆柱形主体的不透射线支架。 管状主体包括钴铬合金，其包括钴，铬和一种或多种不透射线材料。

    Amino acid mimetic copolymers and medical devices coated with the copolymers
    4.
    发明授权
    Amino acid mimetic copolymers and medical devices coated with the copolymers 有权

    公开(公告)号：US08071705B2

    公开(公告)日：2011-12-06

    申请号：US13045464

    申请日：2011-03-10

    申请人： Stephen Pacetti

    发明人： Stephen Pacetti

    IPC分类号： C08F120/58

    CPC分类号： A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L27/18

    摘要： Biocompatible polymers are manufactured to include an amino acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties.

    METHODS FOR MANUFACTURING AMINO ACID MIMETIC COPOLYMERS AND USE OF SAME
    6.
    发明申请
    METHODS FOR MANUFACTURING AMINO ACID MIMETIC COPOLYMERS AND USE OF SAME 有权
    制备氨基酸类共聚物的方法及其用途

    公开(公告)号：US20100183798A1

    公开(公告)日：2010-07-22

    申请号：US12575744

    申请日：2009-10-08

    申请人： Stephen Pacetti

    发明人： Stephen Pacetti

    IPC分类号： B05D1/00

    CPC分类号： A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L27/18

    摘要： A method of using a biocompatible polymer is used. Biocompatible polymers are manufactured to include an ammo acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties.

    摘要翻译： 使用使用生物相容性聚合物的方法。 制备生物相容性聚合物以包含氨基酸模拟单体和一种或多种疏水性丙烯酸酯单体。 选择氨基酸模拟单体以模拟氨基酸天冬酰胺或谷氨酰胺的侧链。 氨基酸模拟单体可以是2-羟基乙酰胺，3-羟基丙酰胺，丙烯酰胺，乳酰胺或甘氨酰胺的甲基丙烯酰基或丙烯酰基衍生物。 这些酰胺官能团具有中等的亲水性，几乎没有化学反应性的优点。 氨基酸模拟单体可以与一种或多种疏水丙烯酸酯单体共聚以获得所需的涂料性质。

    ZWITTERIONIC COPOLYMERS, METHOD OF MAKING AND USE ON MEDICAL DEVICES
    8.
    发明申请
    ZWITTERIONIC COPOLYMERS, METHOD OF MAKING AND USE ON MEDICAL DEVICES 有权
    ZWITTERICIC共聚物，制备和使用医疗设备的方法

    公开(公告)号：US20080147178A1

    公开(公告)日：2008-06-19

    申请号：US11942693

    申请日：2007-11-19

    申请人： Stephen Pacetti ,  Wouter Roorda

    发明人： Stephen Pacetti ,  Wouter Roorda

    IPC分类号： A61F2/82 ,  A61M25/10 ,  A61K47/32 ,  C08F218/02 ,  A61B17/00

    CPC分类号： A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L27/18

    摘要： Biocompatible copolymers are manufactured to include a zwitterionic monomer and an alkoxy acrylate monomer. The alkoxy acrylate monomer can be a 2-methoxyethyl methacrylate (MOEMA) or a 2-methoxyethyl methacrylate (EOEMA). Alternatively, the alkoxy acrylate can be 2-methoxyethyl acrylate (MOEA) or 2-ethoxyethyl acrylate (EOEA). The alkoxy acrylate monomers advantageously give the zwitterionic copolymers greater ductility, strength, and toughness while maintaining a desired amount of hydrophilicity. The improved toughness allows the zwitterionic copolymers to be processed without cross-linking, which improves the elongation properties of the zwitterionic copolymer, and reduces the risk of cracking during use.

    摘要翻译： 制造生物相容性共聚物以包括两性离子单体和烷氧基丙烯酸酯单体。 烷氧基丙烯酸酯单体可以是甲基丙烯酸2-甲氧基乙酯（MOEMA）或甲基丙烯酸2-甲氧基乙酯（EOEMA）。 或者，烷氧基丙烯酸酯可以是丙烯酸2-甲氧基乙酯（MOEA）或丙烯酸2-乙氧基乙酯（EOEA）。 烷氧基丙烯酸酯单体有利地使两性离子共聚物具有更高的延展性，强度和韧性，同时保持所需量的亲水性。 改进的韧性使得两性离子共聚物在不交联的情况下进行加工，这提高了两性离子共聚物的伸长性能，并降低了使用过程中的开裂风险。

    COPOLYMERS HAVING ZWITTERIONIC MOIETIES AND DIHYDROXYPHENYL MOIETIES AND MEDICAL DEVICES COATED WITH THE COPOLYMERS
    9.
    发明申请
    COPOLYMERS HAVING ZWITTERIONIC MOIETIES AND DIHYDROXYPHENYL MOIETIES AND MEDICAL DEVICES COATED WITH THE COPOLYMERS 有权
    具有ZWITTERICIC MOITIES和二羟基苯基酯的共聚物和用共聚物涂覆的医疗装置

    公开(公告)号：US20080139746A1

    公开(公告)日：2008-06-12

    申请号：US11942695

    申请日：2007-11-19

    申请人： Stephen Pacetti

    发明人： Stephen Pacetti

    IPC分类号： C08L33/12 ,  C08G61/00 ,  C08L33/08

    CPC分类号： A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L27/18

    摘要： Copolymers are manufactured to include a zwitterionic monomer (e.g., methacryloyloxyethyl phosphorylcholine monomer), a dihydroxyphenyl derivatized monomer, and optionally one or more additional monomers. The dihydroxyphenyl derivatized monomer gives the copolymers excellent adhesion properties. Optional monomers include a cationic amino monomer, a hydrocarbon monomer, and/or a hydrophilic monomer. The copolymers are biocompatible and can be used with medical devices.

    摘要翻译： 制备共聚物以包括两性离子单体（例如，甲基丙烯酰氧基乙基磷酸胆碱单体），二羟基苯基衍生的单体和任选的一种或多种另外的单体。 二羟基苯基衍生的单体使共聚物具有优异的粘合性能。 任选的单体包括阳离子氨基单体，烃单体和/或亲水单体。 共聚物是生物相容的并且可以与医疗装置一起使用。

    USE OF A TERPOLYMER OF TETRAFLUOROETHYLENE, HEXAFLUOROPROPYLENE, AND VINYLIDENE FLUORIDE IN DRUG ELUTING COATINGS ON MEDICAL DEVICES
    10.
    发明申请
    USE OF A TERPOLYMER OF TETRAFLUOROETHYLENE, HEXAFLUOROPROPYLENE, AND VINYLIDENE FLUORIDE IN DRUG ELUTING COATINGS ON MEDICAL DEVICES 审中-公开
    四氯氟乙烯，十六烷基戊烯和氟乙烯的三聚体在医疗器械中的药物涂层中的应用

    公开(公告)号：US20080118541A1

    公开(公告)日：2008-05-22

    申请号：US11562338

    申请日：2006-11-21

    申请人： Stephen Pacetti

    发明人： Stephen Pacetti

    IPC分类号： A61F2/02 ,  A61L27/00 ,  C08F16/24

    CPC分类号： A61L27/34 ,  A61F2/91 ,  A61L31/10 ,  C08L27/20

    摘要： Medical devices are coated with terpolymers of tetrafluoroethylene, hexafluoropropylene, and vinylidene fluoride (THV). The mole fraction of tetrafluoroethylene can be in a range from about 0.005 to about 0.85, the mole fraction of hexafluoropropylene monomer can be in a range from about 0.005 to about 0.85, and the mole fraction of vinylidene fluoride can be in a range from about 0.005 to about 0.99. One example method of applying the terpolymers to a medical device includes dissolving the terpolymers in a solvent and applying the solution to the medical device and then removing the solvent. The THV coating on the implantable medical devices are advantageously biocompatible.

    摘要翻译： 医疗器械涂覆有四氟乙烯，六氟丙烯和偏二氟乙烯（THV）的三元共聚物。 四氟乙烯的摩尔分数可以在约0.005至约0.85的范围内，六氟丙烯单体的摩尔分数可以在约0.005至约0.85的范围内，偏二氟乙烯的摩尔分数可以在约0.005 至约0.99。 将三元共聚物应用于医疗装置的一个示例性方法包括将三元共聚物溶解在溶剂中并将溶液施加到医疗装置上，然后除去溶剂。 可植入医疗装置上的THV涂层有利地是生物相容的。