公开(公告)号：US06911195B2

公开(公告)日：2005-06-28

申请号：US10320202

申请日：2002-12-16

申请人： Tuan M. Vu ,  Yan-Fei Shen

发明人： Tuan M. Vu ,  Yan-Fei Shen

IPC分类号： A61K8/06 ,  A61K8/28 ,  A61K8/58 ,  A61K8/894 ,  A61K8/898 ,  A61Q15/00 ,  A61K7/32 ,  A61K7/34 ,  A61K7/38 ,  A61K7/00

CPC分类号： A61K8/894 ,  A61K8/0216 ,  A61K8/042 ,  A61K8/06 ,  A61K8/064 ,  A61K8/28 ,  A61K8/585 ,  A61K2800/262 ,  A61K2800/882 ,  A61Q5/065 ,  A61Q5/10 ,  A61Q15/00

摘要： Disclosed are antiperspirant compositions, particularly clear gel antiperspirant compositions, that are water-in-silicone oil emulsions. The emulsion includes a water phase, typically comprising about 65% to about 95% by weight of the emulsion, and a silicone oil phase, typically comprising about 5% to about 35% by weight of the emulsion. The water phase includes an antiperspirant salt dissolved therein, typically in an amount of about 8% to about 30% by weight of the emulsion, the antiperspirant salt comprising a calcium enhanced aluminum-zirconium chlorohydrate. The silicone oil phase contains less than about 5% by weight of the emulsion of a non-volatile oil and includes about 2% to about 25% by weight of the emulsion of a volatile linear silicone.

摘要翻译： 公开了防水剂组合物，特别是透明的凝胶止汗组合物，其是水包硅油乳液。 乳液包括水相，通常占乳液重量的约65％至约95％，硅油相通常占乳液重量的约5％至约35％。 水相包括其中溶解的止汗盐，通常为乳液重量的约8％至约30％，止汗剂盐包含钙增强的铝 - 锆氯化水合物。 硅油相包含小于非挥发性油的乳液的约5重量％，并且包含挥发性线性硅氧烷的乳液的约2重量％至约25重量％。

公开(公告)号：US06649152B2

公开(公告)日：2003-11-18

申请号：US10138476

申请日：2002-05-03

申请人： Angel L. Carrillo ,  Richard Oryszczak ,  Yan-Fei Shen

发明人： Angel L. Carrillo ,  Richard Oryszczak ,  Yan-Fei Shen

IPC分类号： A61K732

CPC分类号： A61Q15/00 ,  A61K8/28 ,  C01G25/006 ,  C01P2002/87 ,  Y10S424/05

摘要： Disclosed are enhanced efficacy aluminum-zirconium antiperspirant salt compositions which exhibit an HPLC peak 5 area content of about 33% or more, preferably at least 45%, more preferably at least 50%, most preferably at least 55%. Especially preferred are aluminum-zirconium antiperspirant salt compositions which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4, preferably at least 0.7. The aforementioned salt compositions will preferably have a metal (Al+Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant salt compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminum-zirconium antiperspirant salt composition as described above.

摘要翻译： 公开了增强的效力铝锆止汗剂盐组合物，其显示出HPLC峰值5面积含量为约33％或更高，优选至少45％，更优选至少50％，最优选至少55％。 特别优选的是铝 - 锆止汗剂盐组合物，除了上述高峰5含量之外，还显示HPLC峰4至峰3面积比至少为0.4，优选至少0.7。 上述盐组合物优选具有约0.90至约1.00的金属（Al + Zr）与氯化物（或阴离子）的比例。 还公开了制备这种止汗剂盐组合物和这种止汗剂盐组合物的水溶液的方法。 进一步公开的是包含皮肤病学可接受的载体载体和减少有效量的如上所述的铝 - 锆止汗剂盐组合物的汗液的局部组合物。

公开(公告)号：US06436381B1

公开(公告)日：2002-08-20

申请号：US09696271

申请日：2000-10-25

申请人： Angel L. Carrillo ,  Richard Oryszczak ,  Yan-Fei Shen

发明人： Angel L. Carrillo ,  Richard Oryszczak ,  Yan-Fei Shen

IPC分类号： A61K732

CPC分类号： A61Q15/00 ,  A61K8/28 ,  C01G25/006 ,  C01P2002/87 ,  Y10S424/05

摘要： Disclosed are enhanced efficacy aluminum-zirconium antiperspirant salt compositions which exhibit an HPLC peak 5 area content of about 33% or more. Especially preferred are aluminum-zirconium antiperspirant salt compositions which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4. The aforementioned salt compositions will preferably have a metal (Al+Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant salt compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminum-zirconium antiperspirant salt composition as described above.

摘要翻译： 公开了增强的效能铝锆防汗剂盐组合物，其显示出HPLC峰值5面积含量为约33％或更高。 特别优选的是铝 - 锆止汗剂盐组合物，除了上述高峰5含量之外，还显示HPLC峰4至峰3面积比至少为0.4。 上述盐组合物优选具有约0.90至约1.00的金属（Al + Zr）与氯化物（或阴离子）的比例。 还公开了制备这种止汗剂盐组合物和这种止汗剂盐组合物的水溶液的方法。 进一步公开的是包含皮肤病学可接受的载体载体和减少有效量的如上所述的铝 - 锆止汗剂盐组合物的汗液的局部组合物。

公开(公告)号：US06245325B1

公开(公告)日：2001-06-12

申请号：US09435183

申请日：1999-11-05

申请人： Yan-Fei Shen

发明人： Yan-Fei Shen

IPC分类号： A61K734

CPC分类号： C01F7/48 ,  A61K8/19 ,  A61K8/26 ,  A61K8/28 ,  A61K8/365 ,  A61K8/44 ,  A61Q15/00

摘要： The present invention relates to enhanced efficacy antiperspirant salts containing calcium and an amino acid or a hydroxy acid and particularly to stabilized aqueous solutions of such salts. The present invention also embraces methods of making these antiperspirant salts and solutions and compositions containing same.

摘要翻译： 本发明涉及包含钙和氨基酸或羟基酸的增强功效止汗剂盐，特别是涉及稳定的这些盐的水溶液。 本发明还包括制备这些止汗盐和含有它们的组合物和组合物的方法。