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261 条记录 (耗时 0.023 秒)

    Personal care compositions comprising coated/treated metal silicate absorbent particles
    1.
    发明授权
    Personal care compositions comprising coated/treated metal silicate absorbent particles 失效
    包含涂覆/处理过的金属硅酸盐吸收颗粒的个人护理组合

    公开(公告)号：US07303767B2

    公开(公告)日：2007-12-04

    申请号：US11050238

    申请日：2005-02-03

    申请人： Michael C. Withiam ,  Donald P. Conley ,  Michael Simone

    发明人： Michael C. Withiam ,  Donald P. Conley ,  Michael Simone

    IPC分类号： A61K9/16 ,  A61K33/06 ,  A61K33/12 ,  A61K7/38 ,  A01N59/06

    CPC分类号： A61Q15/00 ,  A61K8/25

    摘要： Coated particles of metal (such as calcium) silicate that exhibit excellent odor neutralization and sebum absorption properties when present within certain cosmetic and/or personal care formulations and suspensions are provided. Uncoated calcium silicate exhibits a high pH level that may have a deleterious effect upon such cosmetic and/or personal care compositions, thereby rendering the overall composition ineffective for its intended purpose, particularly if the calcium silicate is present in its usual state at high loading levels. Alternatively, if certain materials present within personal care compositions exhibit a sufficiently low pH level, the effectiveness of such calcium silicates may be compromised as well. Such novel coated/treated calcium silicates thus permit high loadings of this beneficial odor neutralizing/sebum absorbing additive within cosmetic and/or personal care formulations without causing any appreciable instability issues or viscosity modification concerns or allow for coexistence with such low pH materials without any appreciable reduction in performance capabilities of the calcium silicates themselves. Certain personal care compositions comprising these novel coated calcium silicate particulates are encompassed within this invention as well.

    摘要翻译： 提供了当存在于某些化妆品和/或个人护理制剂和悬浮液中时显示优异的气味中和和皮脂吸收性质的金属（例如钙）硅酸盐的涂覆颗粒。 未涂覆的硅酸钙表现出高的pH值，其可能对这种化妆品和/或个人护理组合物具有有害影响，从而使整个组合物对其预期目的无效，特别是如果硅酸钙以高负荷水平处于其通常状态 。 或者，如果存在于个人护理组合物内的某些材料表现出足够低的pH水平，则这种硅酸钙的有效性也可能受到影响。 因此，这种新型涂覆/处理的硅酸钙允许在化妆品和/或个人护理制剂中高度负载这种有益气味中和/皮脂吸收添加剂，而不会引起任何明显的不稳定性问题或粘度改变问题，或允许与这种低pH材料共存而没有任何明显的 降低硅酸钙本身的性能能力。 包含这些新型涂覆的硅酸钙颗粒的某些个人护理组合物也包括在本发明内。

    Method and apparatus for performing multiple processing steps on a sample in a single vessel
    4.
    发明授权
    Method and apparatus for performing multiple processing steps on a sample in a single vessel 失效
    在单个容器中对样品进行多个处理步骤的方法和装置

    公开(公告)号：US06964867B2

    公开(公告)日：2005-11-15

    申请号：US10101491

    申请日：2002-03-18

    申请人： Robert Charles Downs

    发明人： Robert Charles Downs

    IPC分类号： C12M1/18 ,  C12M1/34 ,  C12M1/00 ,  A01N43/00 ,  A61K7/38 ,  C12P1/00 ,  C12P21/06

    CPC分类号： C12M23/08 ,  C12M23/12 ,  C12M23/42 ,  C12M23/50 ,  C12M41/48

    摘要： A method is provided for determining crystallization conditions for a protein, the method comprising: performing in a same fermentation apparatus 2 or more separate fermentations where each fermentation comprises cells expressing a protein to be purified and has a fermentation volume of less than 500 mL; purifying the expressed protein from the separate fermentations; and determining crystallization conditions for the purified protein by submicroliter crystallization experiments.

    摘要翻译： 提供了一种用于测定蛋白质的结晶条件的方法，所述方法包括：在相同的发酵设备中进行2个或更多个单独的发酵，其中每个发酵包含表达待纯化蛋白质的细胞，发酵体积小于500mL; 从单独的发酵中纯化表达的蛋白质; 并通过亚微米结晶实验测定纯化蛋白质的结晶条件。

    Enhanced efficacy basic aluminum halides, antiperspirant active compositions and methods for making
    6.
    发明授权
    Enhanced efficacy basic aluminum halides, antiperspirant active compositions and methods for making 失效
    增强功效碱性卤化铝，止汗活性组合物和制备方法

    公开(公告)号：US06902724B1

    公开(公告)日：2005-06-07

    申请号：US10807996

    申请日：2004-03-24

    申请人： Jawahar C. Parekh ,  Pradip Amin

    发明人： Jawahar C. Parekh ,  Pradip Amin

    IPC分类号： A61K8/26 ,  A61Q15/00 ,  A61K7/32 ,  A61K7/00 ,  A61K7/34 ,  A61K7/38

    CPC分类号： A61K8/26 ,  A61Q15/00

    摘要： Disclosed are basic aluminum halides having enhanced antiperspirant efficacy; methods of making such materials and antiperspirant compositions containing such basic aluminum halides, and optionally an amino acid, salts of amino acids, antimicrobial agents, or an organic solvent having at least two carbon atoms and at least one hydroxy group and mixture thereof and methods of making such mixtures. Basic aluminum halides having enhanced antiperspirant efficacy are produced by reacting (a) aluminum powder; (b) an aluminum halide; and (c) water at a temperature greater than about 85° C. This reaction is maintained until reaction products having an Al:halide ratio of about 1.2:1 to 1.5:1 and preferably 1.3 to 1.4:1; and a solution solids concentration of about 30-40 weight percent on an anhydrous basis are obtained. The products are characterized as having a Size Exclusion Chromatography (HPLC) Test Band I of less than 5%, preferably less than 1%, Band II percent aluminum value of 20-60% preferably about 35 to 55%, Band III percent aluminum value of 10 to 35% preferably 15-30% and Band IV value of 15 to 50% and preferably 25 to 35% and sum of peak 3 and 4 areas of at least 45% and no more than 70% and preferably 65%. The enhanced efficacy basic aluminum chloride salts of this invention are more economical to produce, show enhanced efficacy and are more stable compared to the conventional enhanced efficacy aluminum salts which show rapid degradation of Band III to Band II peak areas ratio are less irritant and more skin friendly.

    摘要翻译： 公开了具有增强的止汗功效的碱性卤化铝; 制备这种材料的方法和含有这种碱性卤化铝的任选的止汗组合物，和任选的氨基酸，氨基酸，抗微生物剂或具有至少两个碳原子和至少一个羟基的有机溶剂的盐，以及它们的混合物 制造这样的混合物。 具有增强止汗功效的碱性卤化铝通过（a）铝粉与 （b）卤化铝; 在大于约85℃的温度下加入水。该反应保持至Al:卤化物比为约1.2:1至1.5:1，优选1.3至1.4:1的反应产物; 并且获得以无水为基准的约30-40重量％的溶液固体浓度。 该产品的特征在于尺寸排阻色谱（HPLC）测试条带I小于5％，优选小于1％，带II％铝值为20-60％，优选约35至55％，带III％铝值 10至35％，优选15-30％，并且带IV值为15至50％，优选25至35％，峰3和4面积之和为至少45％且不超过70％，优选为65％。 本发明的增强的功效碱性氯化铝盐与常规增强的功效性铝盐相比，更有效地生产，显示出增强的功效并且更稳定，显示出带III快速降解至Band II峰面积比较少刺激性和更多皮肤 友善。

    Cosmetic composition
    10.
    发明授权
    Cosmetic composition 失效
    化妆品组成

    公开(公告)号：US5985252A

    公开(公告)日：1999-11-16

    申请号：US986815

    申请日：1997-12-08

    申请人： Lynne Hall ,  Gordon Charles Hough

    发明人： Lynne Hall ,  Gordon Charles Hough

    IPC分类号： A61K8/00 ,  A61K8/04 ,  A61Q15/00 ,  A61K7/32 ,  A61K7/00 ,  A61K7/34 ,  A61K7/38

    CPC分类号： A61Q15/00 ,  A61K8/26 ,  A61K8/28 ,  A61K2800/412

    摘要： A suspension antiperspirant composition for topical application to the human skin comprising from 10 to 26% by weight of the composition of a solid particulate antiperspirant active suspended in a cosmetic base, wherein the antiperspirant active comprises a blend of an antiperspirant active with relatively small particles with a volume average particle size in the range of from 0.5 to 8 .mu.m and of an antiperspirant active with relatively large particles having a volume average particle size in the range of larger than 12 to smaller than 50 .mu.m, the weight ratio of the antiperspirant active having smaller particles to the antiperspirant active having larger particles in the composition is in the region of 5:1 to 1:5 by weight.

    摘要翻译： 一种用于局部施用于人体皮肤的悬浮止汗组合物，其包含10至26重量％的所述组合物，所述组合物悬浮在化妆品基质中的固体颗粒止汗剂活性成分，其中所述止汗剂活性物包含具有较小颗粒的止汗活性物与 体积平均粒径在0.5〜8μm的范围内，具有体积平均粒径在12〜50μm以下的较大颗粒的止汗剂，止汗剂的重量比 在组合物中具有较大颗粒的止汗剂活性较小的活性物质的重量比为5:1至1:5。