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1.发明授权Method of forming particles using a supercritical fluid, aerogel particles formed thereby, and antiperspirants containing aerogel particles 失效使用超临界流体形成颗粒的方法，由此形成的气凝胶颗粒和含有气凝胶颗粒的止汗剂
公开(公告)号：US5725836A
公开(公告)日：1998-03-10
申请号：US457522
申请日：1995-06-01
申请人： Stephane Fabrice Rouanet , William Edward McGovern , Wanging Cao , John M. Moses , Angel L. Carrillo , Irving M. Klotz
发明人： Stephane Fabrice Rouanet , William Edward McGovern , Wanging Cao , John M. Moses , Angel L. Carrillo , Irving M. Klotz
IPC分类号： A61K8/00 , A61K8/02 , A61K8/20 , A61K8/23 , A61K8/26 , A61K8/27 , A61K8/28 , A61K8/33 , A61K8/36 , A61K8/49 , A61Q15/00 , B01D9/00 , B01J2/00 , B01J13/00 , C01F7/00 , C01F7/48 , C01F7/56 , C01G25/00 , A61K7/34 , A61K7/56
CPC分类号： A61Q15/00 , A61K8/042 , A61K8/26 , B01J13/0091
摘要： A method for providing aerogels, and aerogels produced according to the method, is described. As one aspect, antiperspirant compounds that are in aerogel form, and antiperspirant and deodorant compositions including such salts, are described. The method involves contacting a solution containing material to be processed with a species selected to precipitate the material and selected so as to be miscible with the solvent system of the solution. After the material is precipitated, the material may be washed with the precipitating species until it is substantially free of solvent system. Then, the precipitating species containing the material precipitate is taken above its critical point, and the supercritical fluid is exhausted above its critical temperature. Alternately, a separate isolating species is introduced to displace the precipitating species, or the precipitating species/solvent system mixture. The isolating species then is taken above its critical point, and exhausted above its critical temperature. The invention provides for batch or continuous processes.
摘要翻译： 描述了一种提供气凝胶和根据该方法生产的气凝胶的方法。 一方面，描述了气凝胶形式的止汗化合物，以及包含这些盐的止汗剂和除臭剂组合物。 该方法包括将待处理材料的溶液与选择的物质接触以沉淀材料并选择以便与溶液的溶剂体系混溶。 材料沉淀后，材料可以用沉淀物质洗涤，直到其基本上不含溶剂体系。 然后，将含有物质沉淀物的沉淀物质高于其临界点，超临界流体在其临界温度以上耗尽。 或者，引入单独的隔离物质以置换沉淀物质或沉淀物质/溶剂体系混合物。 然后将隔离物质置于其临界点以上，并在其临界温度以上耗尽。 本发明提供批量或连续方法。
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2.发明授权Aluminum-zirconium antiperspirant salts made with zirconium salts having low Zr:Cl ratio 有权由Zr：Cl比低的锆盐制成的铝 - 锆止汗盐公开(公告)号：US06663854B1
公开(公告)日：2003-12-16
申请号：US10175250
申请日：2002-06-19
IPC分类号： A61K732
CPC分类号： A61K8/28 , A61Q15/00 , C01G25/006
摘要： Disclosed are enhanced efficacy aluminum-zirconium chlorohydrate antiperspirant salts having a metal (Al+Zr) to chloride ratio of about 0.9 to about 1.2, preferably about 0.9 to about 1.1, most preferably about 0.9 to about 1.0. To achieve the highest possible antiperspirant efficacy, these salts are made with or include a zirconium hydroxychloride of the formula Zr(OH)4−bClb wherein b is about 2.8 to about 4.0, preferably about 3.2 to about 4.0, so that the Zr:Cl ratio in said zirconium hydroxychloride is about 0.36 to about 0.25, preferably about 0.31 to about 0.25. The present invention also embraces methods of making such antiperspirant salts and aqueous solutions of such antiperspirant salts. The present invention further embraces topical compositions comprising a dermatologically acceptable carrier and a perspiration reducing effective amount of an aluminum-zirconium antiperspirant salt as described above.
摘要翻译： 公开了具有约0.9至约1.2，优选约0.9至约1.1，最优选约0.9至约1.0的金属（Al + Zr）与氯化物之比的铝 - 锆氯化水合物止汗剂盐。 为了达到最高的止汗效力，这些盐由式Zr（OH）4-bClb的羟基氯化锆制成，其中b为约2.8至约4.0，优选约3.2至约4.0，使得Zr：Cl 所述羟基氯化锆中的比例为约0.36至约0.25，优选约0.31至约0.25。 本发明还包括制备这种止汗剂盐和这种止汗剂盐的水溶液的方法。 本发明还包括如上所述的包含皮肤病学可接受的载体和减少汗的有效量的铝 - 锆止汗盐的局部组合物。
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3.发明授权Method of making polyhydric alcohol solutions of enhanced efficacy antiperspirant actives 失效制备增效功效多元醇溶液止汗活性物质的方法
公开(公告)号：US5643558A
公开(公告)日：1997-07-01
申请号：US397451
申请日：1995-03-02
申请人： Stephen J. Provancal , Angel L. Carrillo , Thomas J. Fluhler , Richard Oryszczak , Jayant N. Sane
发明人： Stephen J. Provancal , Angel L. Carrillo , Thomas J. Fluhler , Richard Oryszczak , Jayant N. Sane
摘要： The present invention comprises a process of preparing a solution of an enhanced efficacy aluminum antiperspirant salt in a polyhydric alcohol by(a) providing an aqueous solution consisting essentially of about 5% to about 18% by weight of an enhanced efficacy aluminum antiperspirant salt in water, the enhanced efficacy aluminum antiperspirant salt having been prepared in situ without having been dried to a solid powder;(b) mixing the aqueous solution with a sufficient amount of a liquid polyhydric alcohol to provide a mixed solution which has an antiperspirant salt to polyhydric alcohol ratio of about 1:4 to about 1.2:1; and(c) rapidly evaporating the water from the mixed solution under vacuum to provide a final liquid polyhydric alcohol solution containing about 20 to 50% enhanced efficacy aluminum antiperspirant salt and about 2 to 16% water, with the balance being polyhydric alcohol.An alkaline glycinate salt, such as sodium, potassium or zinc glycinate, may be added to the polyhydric alcohol prior to the addition of the antiperspirant salt solution in order to raise the pH of the recovered product to about 4.1 to 5.0.
摘要翻译： 本发明包括通过（a）提供基本上由约5重量％至约18重量％的增强的功效铝止汗酸盐在水中的水溶液制备增强的功效性铝止汗药盐在多元醇中的溶液的方法 已经在原位制备了不再干燥成固体粉末的增强效力的铝止汗药; （b）将水溶液与足量的液体多元醇混合以提供具有止汗剂盐与多元醇比为约1:4至约1.2:1的混合溶液; 和（c）在真空下从混合溶液中快速蒸发水，以提供含有约20至50％增强效力的铝止汗剂盐和约2至16％水的最终液体多元醇溶液，余量为多元醇。 在加入止汗盐溶液之前，可以向多元醇中加入碱性甘氨酸盐，例如甘氨酸钠，钾或锌，以便将回收产物的pH提高至约4.1至5.0。
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公开(公告)号：US06991780B2
公开(公告)日：2006-01-31
申请号：US10700026
申请日：2003-11-03
CPC分类号： A61Q15/00 , A61K8/28 , C01G25/006 , C01P2002/87 , Y10S424/05
摘要： Disclosed are enhanced efficacy aluminum-zirconium antiperspirant salt compositions that have a metal (Al+Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. These salts also typically exhibit an HPLC peak 5 area content of about 33% or more, preferably at least 45%, more preferably at least 50%, most preferably at least 55%. Especially preferred are aluminum-zirconium antiperspirant salt compositions which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4, preferably at least 0.7. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant salt compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminum-zirconium antiperspirant salt composition as described above.
摘要翻译： 公开了具有约0.90至约1.00的金属（Al + Zr）与氯化物（或阴离子）比的增强效力的铝 - 锆止汗剂盐组合物。 这些盐还通常表现出HPLC峰5面积含量为约33％或更高，优选至少45％，更优选至少50％，最优选至少55％。 特别优选的是铝 - 锆止汗剂盐组合物，除了上述高峰5含量之外，还显示HPLC峰4至峰3面积比至少为0.4，优选至少0.7。 还公开了制备这种止汗剂盐组合物和这种止汗剂盐组合物的水溶液的方法。 进一步公开的是包含皮肤病学可接受的载体载体和减少有效量的如上所述的铝 - 锆止汗剂盐组合物的汗液的局部组合物。
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公开(公告)号：US5417964A
公开(公告)日：1995-05-23
申请号：US74079
申请日：1993-06-09
申请人： Jeffrey R. Carlson, Sr. , Craig M. Coe , Angel L. Carrillo , David W. Smith , Nancy M. Karassik
发明人： Jeffrey R. Carlson, Sr. , Craig M. Coe , Angel L. Carrillo , David W. Smith , Nancy M. Karassik
CPC分类号： A61K8/26 , A61K8/0229 , A61K8/39 , A61K8/585 , A61Q15/00 , Y10S424/05
摘要： The present invention provides a process for making a solid antiperspirant stick comprising a particulate aluminum antiperspirant salt suspended in an anhydrous carrier vehicle, wherein said carrier vehicle comprises a high melting component which melts at 70.degree. C. or higher. This process includes heating the carrier vehicle in a closed mixing vessel to a temperature in excess of 70.degree. C. preferably in excess of 75.degree. C., to melt the high melting component, adding the antiperspirant salt to the carrier vehicle, and cooling the carrier vehicle to form a solid antiperspirant stick. The improvement of the present invention comprises cooling the carrier vehicle below 70.degree. C., preferably to about 65.degree. C. or less, but above the solidification point prior to adding the antiperspirant salt and maintaining the carrier vehicle below 70.degree. C., preferably at about 65.degree. C. or less, during and after the antiperspirant salt addition, thereby substantially preventing agglomeration of the antiperspirant salt into large particles, especially particles in excess of 60 microns.
摘要翻译： 本发明提供一种制备固体止汗棒的方法，其包含悬浮在无水载体载体中的颗粒状铝止汗剂盐，其中所述载体载体包含在70℃或更高熔点的高熔点组分。 该方法包括将封闭混合容器中的载体载体加热到超过70℃，优选超过75℃的温度，以熔化高熔点组分，将止汗剂盐加入到载体载体中，并冷却 载体载体形成固体止汗棒。 本发明的改进包括将载体载体冷却至低于70℃，优选至约65℃或更低，但高于固化点，然后加入止汗盐，并将载体载体保持在70℃以下。 约65℃或更低，在止汗盐加入期间和之后，从而基本上防止止汗剂盐结合成大颗粒，特别是超过60微米的颗粒。
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公开(公告)号：US06649152B2
公开(公告)日：2003-11-18
申请号：US10138476
申请日：2002-05-03
IPC分类号： A61K732
CPC分类号： A61Q15/00 , A61K8/28 , C01G25/006 , C01P2002/87 , Y10S424/05
摘要： Disclosed are enhanced efficacy aluminum-zirconium antiperspirant salt compositions which exhibit an HPLC peak 5 area content of about 33% or more, preferably at least 45%, more preferably at least 50%, most preferably at least 55%. Especially preferred are aluminum-zirconium antiperspirant salt compositions which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4, preferably at least 0.7. The aforementioned salt compositions will preferably have a metal (Al+Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant salt compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminum-zirconium antiperspirant salt composition as described above.
摘要翻译： 公开了增强的效力铝锆止汗剂盐组合物，其显示出HPLC峰值5面积含量为约33％或更高，优选至少45％，更优选至少50％，最优选至少55％。 特别优选的是铝 - 锆止汗剂盐组合物，除了上述高峰5含量之外，还显示HPLC峰4至峰3面积比至少为0.4，优选至少0.7。 上述盐组合物优选具有约0.90至约1.00的金属（Al + Zr）与氯化物（或阴离子）的比例。 还公开了制备这种止汗剂盐组合物和这种止汗剂盐组合物的水溶液的方法。 进一步公开的是包含皮肤病学可接受的载体载体和减少有效量的如上所述的铝 - 锆止汗剂盐组合物的汗液的局部组合物。
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公开(公告)号：US06436381B1
公开(公告)日：2002-08-20
申请号：US09696271
申请日：2000-10-25
IPC分类号： A61K732
CPC分类号： A61Q15/00 , A61K8/28 , C01G25/006 , C01P2002/87 , Y10S424/05
摘要： Disclosed are enhanced efficacy aluminum-zirconium antiperspirant salt compositions which exhibit an HPLC peak 5 area content of about 33% or more. Especially preferred are aluminum-zirconium antiperspirant salt compositions which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4. The aforementioned salt compositions will preferably have a metal (Al+Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant salt compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminum-zirconium antiperspirant salt composition as described above.
摘要翻译： 公开了增强的效能铝锆防汗剂盐组合物，其显示出HPLC峰值5面积含量为约33％或更高。 特别优选的是铝 - 锆止汗剂盐组合物，除了上述高峰5含量之外，还显示HPLC峰4至峰3面积比至少为0.4。 上述盐组合物优选具有约0.90至约1.00的金属（Al + Zr）与氯化物（或阴离子）的比例。 还公开了制备这种止汗剂盐组合物和这种止汗剂盐组合物的水溶液的方法。 进一步公开的是包含皮肤病学可接受的载体载体和减少有效量的如上所述的铝 - 锆止汗剂盐组合物的汗液的局部组合物。
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8.发明授权Method of making polyhydric alcohol solutions of enhanced efficacy antiperspirant actives 失效制备增效功效多元醇溶液止汗活性物质的方法
公开(公告)号：US5939057A
公开(公告)日：1999-08-17
申请号：US874232
申请日：1997-06-13
申请人： Stephen J. Provancal , Angel L. Carrillo , Thomas J. Fluhler , Richard Oryszczak , Jayant N. Sane
发明人： Stephen J. Provancal , Angel L. Carrillo , Thomas J. Fluhler , Richard Oryszczak , Jayant N. Sane
IPC分类号： A61K8/20 , A61K8/26 , A61K8/28 , A61K8/34 , A61K8/44 , A61K8/58 , A61K8/86 , A61Q15/00 , A61K7/34 , A61K7/38
摘要： The present invention comprises a process of preparing a solution of an enhanced efficacy aluminum antiperspirant salt in a polyhydric alcohol by(a) providing an aqueous solution consisting essentially of about 5% to about 18% by weight of an enhanced efficacy aluminum antiperspirant salt in water, the enhanced efficacy aluminum antiperspirant salt having been prepared in situ without having been dried to a solid powder;(b) mixing the aqueous solution with a sufficient amount of a liquid polyhydric alcohol to provide a mixed solution which has an antiperspirant salt to polyhydric alcohol ratio of about 1:4 to about 1.2:1; and(c) rapidly evaporating the water from the mixed solution under vacuum to provide a final liquid polyhydric alcohol solution containing about 20 to 50% enhanced efficacy aluminum antiperspirant salt and about 2 to 16% water, with the balance being polyhydric alcohol.An alkaline glycinate salt, such as sodium, potassium or zinc glycinate, may be added to the polyhydric alcohol prior to the addition of the antiperspirant salt solution in order to raise the pH of the recovered product to about 4.1 to 5.0.
摘要翻译： 本发明包括通过（a）提供基本上由约5重量％至约18重量％的增强的功效铝止汗酸盐在水中的水溶液制备增强的功效性铝止汗药盐在多元醇中的溶液的方法 已经在原位制备了不再干燥成固体粉末的增强效力的铝止汗药; （b）将水溶液与足量的液体多元醇混合以提供具有止汗剂盐与多元醇比为约1:4至约1.2:1的混合溶液; 和（c）在真空下从混合溶液中快速蒸发水，以提供含有约20至50％增强效力的铝止汗塞盐和约2至16％水的最终液体多元醇溶液，余量为多元醇。碱性 可以在添加止汗盐溶液之前将甘氨酸盐，例如甘氨酸钠，钾或锌，加入到多元醇中，以将回收产物的pH提高至约4.1至5.0。
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公开(公告)号：US5864923A
公开(公告)日：1999-02-02
申请号：US920287
申请日：1997-08-26
申请人： Stephane Fabrice Rouanet , William Edward McGovern , Wanqing Cao , John M. Moses , Angel L. Carrillo , Irving M. Klotz
发明人： Stephane Fabrice Rouanet , William Edward McGovern , Wanqing Cao , John M. Moses , Angel L. Carrillo , Irving M. Klotz
IPC分类号： A61K8/00 , A61K8/02 , A61K8/20 , A61K8/23 , A61K8/26 , A61K8/27 , A61K8/28 , A61K8/33 , A61K8/36 , A61K8/49 , A61Q15/00 , B01D9/00 , B01J2/00 , B01J13/00 , C01F7/00 , C01F7/48 , C01F7/56 , C01G25/00 , B01D17/00 , C07C7/10
CPC分类号： A61Q15/00 , A61K8/042 , A61K8/26 , B01J13/0091
摘要： A method for providing aerogels, and aerogels produced according to the method, is described. As one aspect, antiperspirant compounds that are in aerogel form, and antiperspirant and deodorant compositions including such salts, are described. The method involves contacting a solution containing material to be processed with a species selected to precipitate the material and selected so as to be miscible with the solvent system of the solution. After the material is precipitated, the material may be washed with the precipitating species until it is substantially free of solvent system. Then, the precipitating species containing the material precipitate is taken above its critical point, and the supercritical fluid is exhausted above its critical temperature. Alternately, a separate isolating species is introduced to displace the precipitating species, or the precipitating species/solvent system mixture. The isolating species then is taken above its critical point, and exhausted above its critical temperature. The invention provides for batch or continuous processes.
摘要翻译： 描述了一种提供气凝胶和根据该方法生产的气凝胶的方法。 一方面，描述了气凝胶形式的止汗化合物，以及包含这些盐的止汗剂和除臭剂组合物。 该方法包括将待处理材料的溶液与选择的物质接触以沉淀材料并选择以便与溶液的溶剂体系混溶。 材料沉淀后，材料可以用沉淀物质洗涤，直到其基本上不含溶剂体系。 然后，将含有物质沉淀物的沉淀物质高于其临界点，超临界流体在其临界温度以上耗尽。 或者，引入单独的隔离物质以置换沉淀物质或沉淀物质/溶剂体系混合物。 然后将隔离物质置于其临界点以上，并在其临界温度以上耗尽。 本发明提供批量或连续方法。
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公开(公告)号：US4478821A
公开(公告)日：1984-10-23
申请号：US342860
申请日：1982-01-26
申请人： Angel L. Carrillo
发明人： Angel L. Carrillo
CPC分类号： A61Q15/00 , A61K8/43 , Y10S424/05
摘要： Inhibition of body odor is obtained by applying polyhexamethylene biguanide hydrochloride to the skin in a dermatologically acceptable carrier.
摘要翻译： 通过在皮肤病学上可接受的载体中将聚六亚甲基双胍盐酸盐应用于皮肤获得体臭的抑制。
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