公开(公告)号：US20140221418A1

公开(公告)日：2014-08-07

申请号：US14251489

申请日：2014-04-11

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Syed Faiyaz Ahmed Hossainy ,  Eugene Michal ,  Thierry Glauser ,  Connie Kwok ,  Stephen Dirk Pacetti

IPC: A61L31/10 ,  A61L31/16

CPC classification number: A61L31/10 ,  A61K31/727 ,  A61K31/728 ,  A61K31/785 ,  A61L31/16 ,  A61K2300/00 ,  C08L5/08 ,  C08L5/10

Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

Abstract translation: 提供了用于涂覆可植入装置的透明质酸（HA）缀合物或交联的HA组合物。 可植入装置可用于治疗动脉粥样硬化，血栓形成，再狭窄，高胆固醇，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管 梗阻，输尿管阻塞，肿瘤阻塞及其组合。

公开(公告)号：US20140100302A1

公开(公告)日：2014-04-10

申请号：US14082922

申请日：2013-11-18

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Stephen Dirk Pacetti ,  Thierry Glauser

IPC: A61L31/10

CPC classification number: A61L31/10 ,  A61L27/34 ,  C08G63/66 ,  C09D167/00

Abstract: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings including block-polymers comprising at least one poly(hydroxyacid) or poly(hydroxy-alkanoate) block, at least one block of a biologically compatible polymer and at least one type of linking moiety.

Abstract translation: 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包括包含至少一种聚（羟基酸）或聚（羟基 - 链烷酸酯）嵌段的嵌段聚合物，至少一个生物相容性聚合物的嵌段和至少 一种类型的连接部分。

公开(公告)号：US20130190854A1

公开(公告)日：2013-07-25

申请号：US13727327

申请日：2012-12-26

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Stephen Dirk Pacetti

IPC: A61F2/958

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2002/9583 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0013 ,  A61F2250/0067 ,  Y10T29/49826

Abstract: A drug-eluting stent delivery system for the treatment of edge restenosis in a blood vessel. The drug-eluting stent delivery system has a balloon disposed about at least a portion of a catheter, the balloon having a first end and a second end and a working length therebetween, the first end and the second end each including a tapered portion, each tapered portion being attached to the catheter, the balloon being inflatable from a collapsed configuration to an inflated configuration. A drug-eluting stent contacts a wall of the blood vessel to maintain the patency of the vessel. The drug-eluting stent has a first end and a second end, the first end and the second end each including a tapered portion, wherein the drug-eluting stent is disposed over the balloon such that at least a portion of the first end and the second end of the balloon are covered by the tapered drug-eluting stent. A method for making the same is also disclosed herein.

Abstract translation: 用于治疗血管中边缘再狭窄的药物洗脱支架递送系统。 药物洗脱支架递送系统具有围绕导管的至少一部分设置的球囊，所述球囊具有第一端和第二端以及其间的工作长度，第一端和第二端各自包括锥形部分，每个 锥形部分附接到导管，气囊可从折叠构型充气到膨胀构型。 药物洗脱支架接触血管的壁以维持血管的通畅。 药物洗脱支架具有第一端和第二端，第一端和第二端各自包括锥形部分，其中药物洗脱支架设置在气囊上方，使得第一端和第二端的至少一部分 气囊的第二端由锥形药物洗脱支架覆盖。 本文还公开了制备该方法的方法。