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公开(公告)号：US09808362B2
公开(公告)日：2017-11-07
申请号：US14712647
申请日：2015-05-14
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed F. A. Hossainy , David C. Gale , Stephen Dirk Pacetti , Bin Huang
CPC classification number: A61F2/86 , A61F2210/0076 , A61F2230/0069 , A61L31/10 , A61L31/129
Abstract: Stents fabricated from polymer composites toughened by a dispersed phase are disclosed.
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公开(公告)号：US20140107148A1
公开(公告)日：2014-04-17
申请号：US14083226
申请日：2013-11-18
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Vidya Nayak , Lothar Kleiner
CPC classification number: C08G69/48 , A61L27/34 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , C08G69/44 , Y10T428/31551 , Y10T428/31725 , C08L77/12
Abstract: This invention relates to poly(ester amide)s (PEAs) comprising inactivated terminal amino and carboxyl groups, methods of synthesizing the inactivated PEAs and uses for them in the treatment of vascular diseases.
Abstract translation: 本发明涉及包含灭活的末端氨基和羧基的聚（酯酰胺）（PEA），合成灭活的PEAs的方法及其用于治疗血管疾病的用途。
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公开(公告)号：US20130129794A1
公开(公告)日：2013-05-23
申请号：US13731875
申请日：2012-12-31
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Lothar Walter Kleiner , Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy , O. Mikael Trollsas , Michael Huy Ngo
IPC: A61L27/34
CPC classification number: A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2420/02
Abstract: Implantable medical devices including a coating having a bioactive agent and a poly(ester amide) polymer. Methods of forming these coatings are also described.
Abstract translation: 可植入医疗装置，包括具有生物活性剂和聚（酯酰胺）聚合物的涂层。 还描述了形成这些涂层的方法。
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公开(公告)号：US20150328375A1
公开(公告)日：2015-11-19
申请号：US14664554
申请日：2015-03-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Thierry Glauser , Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy , Ni Ding
CPC classification number: A61L31/10 , A61L27/34 , A61L31/148 , A61L31/16 , A61L33/0011 , A61L33/08 , A61L2300/40 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2400/18 , C08L33/14
Abstract: A polymer comprising phospholipid moieties and a biocompatible polymer backbone, a composition comprising the polymer and optionally a bioactive agent, an implantable devices such as a DES comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.
Abstract translation: 包含磷脂部分和生物相容性聚合物骨架的聚合物，包含聚合物和任选的生物活性剂的组合物，可植入装置，例如包含其上的包含聚合物和任选的生物活性剂的涂层的DES，以及使用该装置的方法 提供了人类疾病的治疗。
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公开(公告)号：US09067000B2
公开(公告)日：2015-06-30
申请号：US14083226
申请日：2013-11-18
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Vidya Nayak , Lothar Kleiner
CPC classification number: C08G69/48 , A61L27/34 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , C08G69/44 , Y10T428/31551 , Y10T428/31725 , C08L77/12
Abstract: This invention relates to poly(ester amide)s (PEAs) comprising inactivated terminal amino and carboxyl groups, methods of synthesizing the inactivated PEAs and uses for them in the treatment of vascular diseases.
Abstract translation: 本发明涉及包含灭活的末端氨基和羧基的聚（酯酰胺）（PEA），合成灭活的PEAs的方法及其用于治疗血管疾病的用途。
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Patent Agency Ranking
公开(公告)号：US20140249475A1
公开(公告)日：2014-09-04
申请号：US14280441
申请日：2014-05-16
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Dirk Pacetti
IPC: A61B17/3207 , A61M25/10
CPC classification number: A61B17/320725 , A61B17/22032 , A61B2017/22081 , A61M25/10 , A61M29/02 , A61M2025/1097
Abstract: Embodiments include a medical device having a balloon portion with a first end, a second end, and a variable balloon mass to inflate the balloon portion non-uniformly from the first end to the second end. In one embodiment, the balloon portion inflates in a controlled manner to rupture a vulnerable plaque near the second end.
Abstract translation: 实施例包括具有第一端的球囊部分，第二端和可变球囊的医疗装置，以使球囊部分从第一端不均匀地膨胀到第二端。 在一个实施例中，球囊部分以受控的方式膨胀以破坏靠近第二端的易损斑块。
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公开(公告)号：US09603976B2
公开(公告)日：2017-03-28
申请号：US14323816
申请日：2014-07-03
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Dirk Pacetti
CPC classification number: A61L31/10 , A61L27/00 , A61L27/14 , A61L27/34 , A61L31/08 , A61L31/148 , A61L2420/00 , A61L2420/02
Abstract: Biodegradable coatings for implantable medical devices are disclosed.
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公开(公告)号：US09539332B2
公开(公告)日：2017-01-10
申请号：US14621301
申请日：2015-02-12
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Dirk Pacetti , Yiwen Tang , Syed Faiyaz Ahmed Hossainy
IPC: A61F2/00 , A61K39/00 , A61F2/06 , A61F2/02 , A61K38/22 , A61K38/00 , A61K31/44 , A61K31/445 , A61K47/34 , A61L27/34 , A61L27/50 , A61L31/10 , A61L31/14 , A61K31/436 , C08K5/1575 , C09D167/00
CPC classification number: A61K47/34 , A61K31/436 , A61L27/34 , A61L27/502 , A61L31/10 , A61L31/141 , C08K5/1575 , C08L67/04 , C09D167/00
Abstract: A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive agent. The coating composition can form a coating on an implantable device. The implantable device can be used to treat or prevent a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
Abstract translation: 提供了可用于形成具有生物相容性聚合物的涂料组合物的生物相容性增塑剂。 涂料组合物还可以包括生物有益的聚合物和/或生物活性剂。 涂料组合物可以在可植入装置上形成涂层。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管阻塞 ，输尿管阻塞，肿瘤阻塞或其组合。
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公开(公告)号：US20150267000A1
公开(公告)日：2015-09-24
申请号：US14732568
申请日：2015-06-05
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Vidya Nayak , Lothar Kleiner
CPC classification number: C08G69/48 , A61L27/34 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , C08G69/44 , Y10T428/31551 , Y10T428/31725 , C08L77/12
Abstract: This invention relates to poly(ester amide)s (PEAs) comprising inactivated terminal amino and carboxyl groups, methods of synthesizing the inactivated PEAs and uses for them in the treatment of vascular diseases.
Abstract translation: 本发明涉及包含灭活的末端氨基和羧基的聚（酯酰胺）（PEA），合成灭活的PEAs的方法及其用于治疗血管疾病的用途。
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公开(公告)号：US20150150989A1
公开(公告)日：2015-06-04
申请号：US14621301
申请日：2015-02-12
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen Dirk Pacetti , Yiwen Tang , Syed Faiyaz Ahmed Hossainy
IPC: A61K47/34 , C09D167/00 , C08K5/1575 , A61K31/436
CPC classification number: A61K47/34 , A61K31/436 , A61L27/34 , A61L27/502 , A61L31/10 , A61L31/141 , C08K5/1575 , C08L67/04 , C09D167/00
Abstract: A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive agent. The coating composition can form a coating on an implantable device. The implantable device can be used to treat or prevent a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof
Abstract translation: 提供了可用于形成具有生物相容性聚合物的涂料组合物的生物相容性增塑剂。 涂料组合物还可以包括生物有益的聚合物和/或生物活性剂。 涂料组合物可以在可植入装置上形成涂层。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管阻塞 ，输尿管阻塞，肿瘤阻塞或其组合
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