公开(公告)号：US10981923B2

公开(公告)日：2021-04-20

申请号：US16905667

申请日：2020-06-18

Applicant: AbbVie Inc.

Inventor： Ayman Allian ,  Thomas B. Borchardt ,  Jayanthy Jayanth ,  Patrick J. Marroum ,  Peter T. Mayer ,  Mathew M. Mulhern ,  Fredrik Lars Nordstrom ,  Ahmad Y. Sheikh

IPC: C07D487/14 ,  A61K47/38 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US09879018B2

公开(公告)日：2018-01-30

申请号：US15682451

申请日：2017-08-21

Applicant: AbbVie Inc.

Inventor： Mathew M. Mulhern ,  Lars Fredrick Nordstroem ,  Ahmad Y. Sheikh

IPC: C07D487/14 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  A61K9/00

CPC classification number: C07D487/14 ,  A61K9/0053 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US09238652B2

公开(公告)日：2016-01-19

申请号：US14637639

申请日：2015-03-04

Applicant: AbbVie Inc.

Inventor： Jufang Barkalow ,  Jean-Christophe Califano ,  Vincent S. Chan ,  Alan C. Christesen ,  Timothy A. Grieme ,  Yi-Yin Ku ,  Mathew M. Mulhern ,  Yu-Ming M. Pu

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.

公开(公告)号：US20150252042A1

公开(公告)日：2015-09-10

申请号：US14637639

申请日：2015-03-04

Applicant: AbbVie Inc.

Inventor： Jufang Barkalow ,  Jean-Christophe Califano ,  Vincent S. Chan ,  Alan C. Christesen ,  Timothy A. Grieme ,  Yi-Yin Ku ,  Mathew M. Mulhern ,  Yu-Ming M. Pu

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.

公开(公告)号：US09006438B2

公开(公告)日：2015-04-14

申请号：US14207179

申请日：2014-03-12

Applicant: AbbVie Inc.

Inventor： Vincent S. Chan ,  Alan C. Christesen ,  Timothy A. Grieme ,  Yi-Yin Ku ,  Mathew M. Mulhern ,  Yu-Ming M. Pu

IPC: C07D471/04 ,  C07C67/10

CPC classification number: C07D471/04 ,  C07C67/00 ,  C07C67/10 ,  C07C69/78 ,  C07C69/76

Abstract: Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.

Abstract translation: 本文提供了一种制备凋亡诱导剂及其化学中间体的方法。 本文还提供了与本文提供的方法相关的新型化学中间体。