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公开(公告)号:US08741573B2
公开(公告)日:2014-06-03
申请号:US12377073
申请日:2007-08-13
申请人: Tobias Sjoblom , Sian Jones , D. Williams Parsons , Laura D. Wood , Jimmy Lin , Thomas Barber , Diana Mandelker , Bert Vogelstein , Kenneth W. Kinzler , Victor E. Velculesu
发明人: Tobias Sjoblom , Sian Jones , D. Williams Parsons , Laura D. Wood , Jimmy Lin , Thomas Barber , Diana Mandelker , Bert Vogelstein , Kenneth W. Kinzler , Victor E. Velculesu
CPC分类号: C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要: Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.
摘要翻译: 分析11个乳房和11个结直肠癌中的13,023个基因显示,个体肿瘤平均累积〜90个突变基因,但只有其中一个子集对肿瘤过程有贡献。 使用严格的标准来描绘这一亚型,我们确定了189个基因(平均每个肿瘤11个),以显着的频率突变。 这些基因绝大多数不知道在肿瘤中被遗传改变,并被预测会影响广泛的细胞功能,包括转录,粘附和侵袭。 这些数据定义了两种人类癌症类型的遗传景观,为诊断和治疗干预和监测提供了新的目标。
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公开(公告)号:US20130105520A1
公开(公告)日:2013-05-02
申请号:US13287904
申请日:2011-11-02
摘要: A batter dispenser and a method of using the batter dispenser are provided. The batter dispenser includes a lower body, an upper body detachably connected to the lower body, and a dispenser member detachably connected to the upper body, the dispenser member including a first nozzle configured to control the flow of batter therethrough. The method includes placing a dry-mix ingredient of a batter into the lower body, adding a liquid ingredient of the batter to the dry-mix ingredients, assembling the batter dispenser by connecting the lower body, the upper body, and the dispensing member, shaking the batter dispenser to mix the dry-mix ingredient and the liquid ingredient to form the batter, and squeezing the upper body to cause batter to flow out of batter dispenser.
摘要翻译: 提供一种面糊分配器和使用面糊分配器的方法。 糊状分配器包括下体,可拆卸地连接到下体的上体和可拆卸地连接到上体的分配器,分配器构件包括构造成控制面糊通过其流动的第一喷嘴。 该方法包括将面糊的干混成分放入下体内,将面糊的液体成分加入到干混成分中,通过连接下体,上体和分配部件组装糊剂分配器, 摇动面糊分配器以混合干混成分和液体成分以形成面糊,并且挤压上身以使面糊从面糊分配器中流出。
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公开(公告)号:USD638254S1
公开(公告)日:2011-05-24
申请号:US29379975
申请日:2010-11-29
申请人: Thomas Barber
设计人: Thomas Barber
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公开(公告)号:US07665359B2
公开(公告)日:2010-02-23
申请号:US12110887
申请日:2008-04-28
申请人: Thomas Barber
发明人: Thomas Barber
IPC分类号: G01F19/00
摘要: A pouring vessel is provided that includes a body having a bottom, a sidewall extending from the bottom, and an opening substantially opposite the bottom, the opening being defined by the sidewall. The pouring vessel also includes a handle connected to the body adjacent the opening. The handle includes a free end distal from the body and a through hole located adjacent the sidewall for receiving an elongated member while hanging from a display.
摘要翻译: 提供了一种浇注容器,其包括具有底部的主体,从底部延伸的侧壁和基本上与底部相对的开口,该开口由侧壁限定。 浇注容器还包括与开口相邻的主体连接的手柄。 手柄包括远离主体的自由端和邻近侧壁设置的通孔,用于在从显示器悬挂的同时接收细长构件。
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公开(公告)号:US07614518B2
公开(公告)日:2009-11-10
申请号:US11372273
申请日:2006-03-10
申请人: Thomas Barber
发明人: Thomas Barber
CPC分类号: A21C15/00
摘要: A holder for cupcakes, muffins or other baked goods comprising at least two spaced pans and a transparent protective cover, the upper pan having wide legs at opposite ends with feet engaging the lower pan and clamped between handles on the cover and the lower pan to hold the upper pan in place. Pivoted latches secure the handles releasably together for toting of the holder by a top handle on the cover, and include arcuate, channel-shaped members that are flush with the end handles when latched.
摘要翻译: 一种用于纸杯蛋糕,松饼或其他烘焙食品的保持器,包括至少两个间隔开的平底锅和透明保护罩,上部锅具有相对两端的宽腿部,脚部接合下部锅盘并夹在盖子上的把手和下部锅板之间以保持 上盘在适当位置。 枢轴闩锁将手柄可释放地固定在一起,用于通过盖上的顶部手柄来挡住保持件,并且包括当锁定时与端把手齐平的弓形通道形构件。
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公开(公告)号:US20060225581A1
公开(公告)日:2006-10-12
申请号:US11372273
申请日:2006-03-10
申请人: Thomas Barber
发明人: Thomas Barber
IPC分类号: A23P1/00
CPC分类号: A21C15/00
摘要: A holder for cupcakes, muffins or other baked goods comprising at least two spaced pans and a transparent protective cover, the upper pan having wide legs at opposite ends with feet engaging the lower pan and clamped between handles on the cover and the lower pan to hold the upper pan in place. Pivoted latches secure the handles releasably together for toting of the holder by a top handle on the cover, and include arcuate, channel-shaped members that are flush with the end handles when latched.
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公开(公告)号:US20060069175A1
公开(公告)日:2006-03-30
申请号:US11272924
申请日:2005-11-14
IPC分类号: C08G18/00
CPC分类号: C08G18/4213 , C08G18/18 , C08G18/302 , C08G18/7664 , C08G2101/0025
摘要: Aromatic polyester polyols, and foams produced therefrom, having an acid number below 3.0 mg/KOH/g, wherein the aromatic polyester polyol is the reaction product of a reaction mixture comprising an acid component, a glycol component, and a urethane catalytic activity agent comprising at least one of a non-alkoxylated aminoalcohol and a metal esterification catalyst.
摘要翻译: 芳族聚酯多元醇和由其制备的泡沫,酸值低于3.0mg / KOH / g,其中芳族聚酯多元醇是包含酸组分,二醇组分和氨基甲酸酯催化活性剂的反应混合物的反应产物,其包含 至少一种非烷氧基化氨基醇和金属酯化催化剂。
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公开(公告)号:US20050263211A1
公开(公告)日:2005-12-01
申请号:US10858948
申请日:2004-05-28
CPC分类号: B60K15/04 , Y10S220/33
摘要: A fuel filler neck assembly having a uniform hemmed connection between an outer funnel portion and an inner funnel portion. The outer funnel portion is typically defined by an offset-expanded cylinder and sidewalls of varying thickness. The inner funnel portion includes sidewalls that have an internal thread, which is configured to mate with the threads of a gas cap. A hemmed connection is used to join one end of the outer funnel portion to one end of the inner funnel portion. The sidewalls at one end of the outer funnel portion are folded or bent inwardly and around the rim portion to define a curled portion. A tooling assembly for producing a uniform hemmed connection between one end of the outer funnel portion and one end of the inner funnel portion. A method of producing a uniform hemmed connection between portions of a fuel filler neck.
摘要翻译: 一种燃料填充器颈部组件,其在外漏斗部分和内漏斗部分之间具有均匀的卷边连接。 外漏斗部分通常由偏移扩大的圆筒和不同厚度的侧壁限定。 内漏斗部分包括具有内螺纹的侧壁,其构造成与气帽的螺纹配合。 使用褶边连接将外漏斗部分的一端连接到内漏斗部分的一端。 外漏斗部分的一端的侧壁被折叠或向内弯曲并围绕边缘部分以限定卷曲部分。 一种用于在外漏斗部分的一端和内漏斗部分的一端之间产生均匀的卷边连接的加工组件。 一种在燃料填充器颈部的部分之间产生均匀的褶皱连接的方法。
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公开(公告)号:USD503540S1
公开(公告)日:2005-04-05
申请号:US29190168
申请日:2003-09-16
申请人: Thomas Barber
设计人: Thomas Barber
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