公开(公告)号：US20050032148A1

公开(公告)日：2005-02-10

申请号：US10926544

申请日：2004-08-25

申请人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Kunihiko Shibata ,  Asuka Ito

发明人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Kunihiko Shibata ,  Asuka Ito

IPC分类号： A61K49/06 ,  A61K49/18 ,  A61K51/04 ,  A61K51/06 ,  A61K51/12 ,  C08B37/00 ,  C12Q1/40

CPC分类号： A61K51/0491 ,  A61K49/10 ,  A61K49/126 ,  A61K49/1815 ,  A61K49/189 ,  A61K51/06 ,  A61K51/1206 ,  A61K51/1268 ,  B82Y5/00 ,  C07H3/06 ,  C08B37/00

摘要： The present invention provides a 13C-labeled oligosaccharide or polysaccharide or a salt thereof excluding U-13C-maltose, 13C-starch, 1-13C-maltotetraose and 1-13C-amylose; a derivative of the 13C-labeled oligosaccharide or polysaccharide or salt thereof; a 13C-labeled inclusion complex or a salt thereof, which comprises a cyclodextrin or a modified derivative thereof as a host molecule; a 13C- or 14C-labeled fluorescein ester compound or a salt thereof; and a diagnostic agents for pancreatic exocrine function comprising these compounds 13C- or 14C-labeled.

公开(公告)号：US06509002B1

公开(公告)日：2003-01-21

申请号：US09176246

申请日：1998-10-21

申请人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Asuka Ito ,  Kunihiko Shibata

发明人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Asuka Ito ,  Kunihiko Shibata

IPC分类号： A61K5100

CPC分类号： A61K51/1206 ,  A61K49/1815

摘要： The present invention relates to a diagnostic agent for diabetes, comprising a compound labelled with 13C at least at one specific position selected from the group consisting of the following (a) to (g): (a) galactose, fructose or xylose labelled with 13C at least atone specific position, or a starch composed of glucose units labelled with 13C at least at one specific position; (b) an amino acid labelled with 13C at least at one specific position; (c) lactic acid or citric acid labelled with 13C at least at one specific position; (d) a fatty acid labelled with 13C at least at one specific position; (e) a glyceride labelled with 13C at least at one specific position; (f) glycerol labelled with 13C at least at one specific position; and (g) aminopyrin of which the dimethylamino group at position 4 is labelled with 13C, phenacetin of which the ethoxy group is labelled with 13C at position 1, or methacetin of which the methoxy group is labelled with 13C. According to the present invention, there is provided a diagnostic agent for diabetes which does not impose a heavy physical burden on a subject, can give accurate test results immediately and can be used safely without side effects. The diagnostic agent of the invention makes it possible to discriminate patients with diabetes from normal subjects even under circumstances where patients are easily missed.

摘要翻译： 本发明涉及一种用于糖尿病的诊断剂，其包含用13C标记的至少一个特定位置的化合物，所述化合物选自以下（a）至（g）:( a）用13C标记的半乳糖，果糖或木糖 至少在一个特定位置，或由至少在一个特定位置用13C标记的葡萄糖单元组成的淀粉;（b）用13C至少在一个特定位置标记的氨基酸;（c）用13C标记的乳酸或柠檬酸 至少在一个具体位置;（d）至少在一个特定位置用13C标记的脂肪酸;（e）至少在一个特定位置用13C标记的甘油酯;（f）用13C标记的至少一个特定的 位置; 和（g）其中第4位的二甲氨基用13C标记的氨基吡啶，其中乙氧基被1位13C标记的非那西丁或甲氧基用13C标记的美沙西丁。根据本发明， 提供了不对受试者施加沉重的身体负担的糖尿病诊断剂，可以立即给出准确的测试结果，并且可以安全使用而没有副作用。 本发明的诊断剂即使在容易错过患者的情况下也能够将糖尿病患者与正常人区分开来。

公开(公告)号：US06174730B1

公开(公告)日：2001-01-16

申请号：US09151940

申请日：1998-09-11

申请人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Asuka Ito ,  Kunihiko Shibata

发明人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Asuka Ito ,  Kunihiko Shibata

IPC分类号： G01N3368

CPC分类号： A61K51/1206 ,  A61K51/0402 ,  A61K51/0491 ,  Y10S436/811 ,  Y10S436/90

摘要： The present invention relates to a reagent for evaluating a hepatic operation, comprising an aromatic amino acid, methionine, alanine, fructose or galactose labelled with 13C at least at one position. According to the present invention, there is provided a reagent for evaluating a hepatic operation, which imposes less physical burden on a subject, can give accurate test results immediately and can be used safely without side effects. The reagent of the invention is useful for measuring the accurate liver excision ratio, liver regeneration/increase ratio or liver weight of a subject after a hepatic operation. With the reagent of the invention, information which is useful for evaluating a hepatic operation and the degree of invasion by the operation and for diagnosis is provided.

摘要翻译： 本发明涉及用于评估肝操作的试剂，其包含至少在一个位置用13 C标记的芳香族氨基酸，甲硫氨酸，丙氨酸，果糖或半乳糖。 根据本发明，提供了一种用于评价肝脏操作的试剂，其对受试者施加较少的身体负担，可以立即给出准确的测试结果，并且可以安全使用而没有副作用。 本发明的试剂可用于测量肝脏操作后受试者的精确肝切除率，肝脏再生/增加比例或肝脏重量。 利用本发明的试剂，提供了可用于评估肝脏操作和通过操作和诊断的入侵程度的信息。

公开(公告)号：US5916538A

公开(公告)日：1999-06-29

申请号：US918378

申请日：1997-08-26

申请人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Kunihiko Shibata

发明人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Kunihiko Shibata

IPC分类号： A61K49/00 ,  A61K49/18 ,  A61K51/12 ,  G01N24/00 ,  G01N37/00

CPC分类号： A61K51/1206 ,  A61K49/00 ,  A61K49/1815 ,  Y10S436/90 ,  Y10T436/13 ,  Y10T436/24

摘要： The present invention relates to a method of diagnosing diabetes, which comprises administering a diagnostic agent comprising glucose labeled with .sup.13 C at a specific position, or pyruvic acid labeled with .sup.13 C in at least one specific position. According to the present invention, there is provided a method of diagnosing diabetes by administering a diagnostic agent which can be used safely without side effects to give accurate results immediately with less physical pains on the subject. The present method of diagnosing diabetes can distinguish between healthy persons and patients with diabetes even under the circumstances where the patients are easily missed, and further it can determine the type of diabetes (insulin-dependent type or insulin-independent type).

摘要翻译： 糖尿病诊断方法技术领域本发明涉及一种糖尿病诊断方法，其特征在于，在特定位置给予包含用13C标记的葡萄糖的诊断剂，或在至少一个特定位置上以13℃标记的丙酮酸。 根据本发明，提供一种诊断糖尿病的方法，其可以安全使用的诊断剂，而不会产生副作用，以便在受试者身体疼痛较少的情况下立即给出准确的结果。 目前的糖尿病诊断方法即使在患者容易漏诊的情况下也能区分健康人和糖尿病患者，进一步判断糖尿病（胰岛素依赖型或胰岛素依赖型）。

公开(公告)号：US06214317B1

公开(公告)日：2001-04-10

申请号：US09294616

申请日：1999-04-19

申请人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Kunihiko Shibata

发明人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Kunihiko Shibata

IPC分类号： A61K4900

CPC分类号： A61K51/1206 ,  A61K49/00 ,  A61K49/1815 ,  Y10S436/90 ,  Y10T436/13 ,  Y10T436/24

摘要： The present invention relates to a diagnostic agent for diabetes, which comprises glucose labelled with 13C at a specific position, or pyruvic acid labelled with 13C at least one specific position. According to the present invention, there is provided a diagnostic agent for diabetes which can be used safely without side effects to give accurate results immediately with less physical pains on the subject. The present diagnostic agent for diabetes can distinguish between healthy persons and patients with diabetes even under the circumstances where the patients are easily missed, and further it can determine the type of diabetes (insulin-dependent type or insulin-independent type).

摘要翻译： 本发明涉及一种用于糖尿病的诊断剂，其包括在特定位置用13C标记的葡萄糖或由13 C至少一个特定位置标记的丙酮酸。 根据本发明，提供了可以安全使用的糖尿病诊断剂，而不会产生副作用，以便在受试者身体疼痛较少的情况下立即给出准确的结果。 目前的糖尿病诊断剂即使在患者容易遗漏的情况下也能区分健康人和糖尿病患者，并且还可以确定糖尿病的类型（胰岛素依赖型或胰岛素依赖型）。

公开(公告)号：US4525092A

公开(公告)日：1985-06-25

申请号：US566970

申请日：1983-12-30

申请人： Takahiko Shimizu ,  Hishao Fukui ,  Tadashi Kohno

发明人： Takahiko Shimizu ,  Hishao Fukui ,  Tadashi Kohno

IPC分类号： B43K1/06 ,  B43K15/00

CPC分类号： B43K1/06

摘要： In a nib structure of a writing instrument of the type having a tubular nib fitted to a forward end of a tubular tip of the instrument, the tubular nib is provided with a concentrically reduced diameter portion having an outer surface gently sloped from the ends toward a middle portion of the nib, and a radiused peripheral edge at a rearward end of the nib. The nib structure provides easy and accurate fitting of the nib into the tubular tip.

摘要翻译： PCT No.PCT / JP81 / 00066 Sec。 371日期1982年3月19日 102（e）1982年3月19日PCT申请日1982年3月26日PCT公布。 出版物WO82 / 03360 日期为1982年10月14日。在具有装配到仪器的管状尖端的前端的管状笔尖的书写工具的笔尖结构中，管状笔尖具有同心直径减小的部分，其具有外表面 从端部朝向笔尖的中间部分轻轻地倾斜，并且在笔尖的后端处具有圆角的周边边缘。 笔尖结构提供将笔尖容易且精确地装配到管状尖端中。

公开(公告)号：US4364684A

公开(公告)日：1982-12-21

申请号：US158387

申请日：1980-06-11

申请人： Tadashi Kohno ,  Takahiko Shimizu ,  Kenji Takahashi ,  Hishao Fukui ,  Akio Okubo ,  Noriaki Masuda

发明人： Tadashi Kohno ,  Takahiko Shimizu ,  Kenji Takahashi ,  Hishao Fukui ,  Akio Okubo ,  Noriaki Masuda

IPC分类号： B43K5/18 ,  B43K3/04

CPC分类号： B43K5/1845

摘要： A writing instrument comprises a writing nib having a writing tip at one end and an enlarged head portion at the other end, and a resilient seat urging the head portion of the nib toward a tip of the instrument. The nib is movably secured in a nib holder body in such a manner that a writing pressure enables the nib to move backward against the resilient force of the seat to form an ink-feed space between the head portion and the nib holder body. When the writing instrument is not in use, the head portion is engaged with the nib holder body to close the ink-feed space.

摘要翻译： 一种书写工具，包括：一端具有书写尖端和另一端具有扩大头部的书写笔尖;以及一弹性座，其朝向该器具的尖端推动笔尖的头部。 笔尖可移动地固定在笔尖保持器主体中，使得书写压力使得笔尖能够抵抗座椅的弹力向后移动，以在头部和笔尖座之间形成供墨空间。 当书写工具不使用时，头部与笔尖保持体接合以封闭供墨空间。

公开(公告)号：US20050229781A1

公开(公告)日：2005-10-20

申请号：US10505888

申请日：2003-03-07

申请人： Kazuhide Hori ,  Naoto Mikami ,  Tadashi Kohno ,  Kiyoto Inomata

发明人： Kazuhide Hori ,  Naoto Mikami ,  Tadashi Kohno ,  Kiyoto Inomata

IPC分类号： B01D53/04 ,  B01D59/04 ,  B01D59/26 ,  B01D59/50 ,  B01J20/22 ,  C07B63/00 ,  C07C7/13 ,  C07C9/04 ,  F25J3/02 ,  B01D53/02

CPC分类号： B01D59/26 ,  B01D59/04 ,  B01D59/50 ,  Y02C20/20

摘要： A isotopic gas of high purity is obtained at low cost, wherein for example, in a case of separating 13CH4 from methane gas and obtaining 13CH4 of high purity, the enrichment of 13CH4, using the difference in adsorption of 12CH4 and 13CH4 onto an adsorbing material, is performed up to a certain concentration, and thereafter, 13CH4 is enriched by a separation method by distillation that uses the difference in boiling point.

摘要翻译： 以低成本获得了高纯度的同位素气体，其中例如在从甲烷气体中分离出来的情况下，得到13重量％ 高纯度CH 3，高浓度的CH 4，使用12 H 12 CH 3的吸附差异 将4＆lt; 3＆gt;和＆lt; 13＆lt; 3＆lt; 3＆lt; 3＆lt; 4＆lt; 4＆gt;到吸附材料上，进行一定浓度，然后， CH 4通过使用沸点差的通过蒸馏的分离方法富集。