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    Diagnostic agents for pancreatic exocrine function
    1.
    发明授权
    Diagnostic agents for pancreatic exocrine function 失效
    胰腺外分泌功能诊断剂

    公开(公告)号：US07232559B1

    公开(公告)日：2007-06-19

    申请号：US09453642

    申请日：1999-12-03

    申请人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Kunihiko Shibata ,  Asuka Ito

    发明人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Kunihiko Shibata ,  Asuka Ito

    IPC分类号： A61K51/00 ,  A61M36/14

    CPC分类号： C07K7/06 ,  A61K49/1815 ,  A61K51/1206 ,  C07K5/06026 ,  C07K5/06078 ,  C07K5/06095 ,  C12Q1/37 ,  Y02P20/55

    摘要： A diagnostic agent for pancreatic exocrine function comprising an amino acid or a peptide containing at least one 13C or 14C atom, or a pharmaceutically acceptable salt thereof other than Bz-Tyr-13C-PABA is provided. A 13C- or 14C-labeled compound represented by the following formula (II): X2—R2—Y2—Z1   (II) or a salt thereof, wherein X2 is a hydrogen atom or a protecting group, R2 is a peptide of 2 to 5 amino acids, an amino acid or a single bond, Y2 is an amino acid, Z1 is an amino acid optionally having a protecting group, and at least one of the amino acids in R2, Y2 and Z1, or at least one of the protecting groups in X2 and Z1 when the protecting groups contain a carbon atom, is 13C or 14C-labeled.

    摘要翻译： 胰腺外分泌功能的诊断剂，其包含氨基酸或含有至少一个13个或多个14个C原子的肽或其除Bz-Tyr之外的其药学上可接受的盐 提供了C-PABA。 由下式（II）表示的C 13 - 或 - 14 C标记化合物：<？in-line-formula description =“In-line Formulas”end = “铅”→X 2→R 2 -Y 2 -Z 1（II）<β -line-formula description =“In-line Formulas”end =“tail”？>或其盐，其中X 2是氢原子或保护基，R 2， SUB>是2至5个氨基酸，氨基酸或单键的肽，Y 2是氨基酸，Z 1是任选具有 保护基和R 2，Y 2和Z 1中的至少一个氨基酸，或至少一个保护基 在保护基含有碳原子的情况下，X 2和Z 1中的至少一个是13或C 14 - 标记。

    Diagnostic agent for liver function
    5.
    发明授权
    Diagnostic agent for liver function 有权
    肝功能诊断剂

    公开(公告)号：US6071245A

    公开(公告)日：2000-06-06

    申请号：US164710

    申请日：1998-10-01

    申请人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Asuka Ito ,  Kunihiko Shibata

    发明人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Asuka Ito ,  Kunihiko Shibata

    IPC分类号： A61K51/04 ,  A61K51/12 ,  A61B5/08

    CPC分类号： A61K51/1206

    摘要： The present invention relates to a diagnostic agent for liver function, comprising a compound labelled with .sup.13 C at least at one specific position selected from the group consisting of the following (a) to (f):(a) galactose, glucose or xylose labelled with .sup.13 C at least at one specific position or a starch composed of glucose units labelled with .sup.13 C at least at one specific position;(b) a polar amino acid, heterocyclic amino acid, isoleucine or valine labelled with .sup.13 C at least at one specific position;(c) a carboxylic acid constituting the glycolytic pathway or the citric acid cycle, labelled with .sup.13 C at least at one specific position;(d) a fatty acid labelled with .sup.13 C at least at one specific position;(e) a glyceride labelled with .sup.13 C at least at one specific position; and(f) glycerol labelled with .sup.13 C at least at one specific position.According to the present invention, a diagnostic agent for liver function which imposes less physical burden on a subject, can give accurate test result immediately, and can be used safely without side effects is provided. The diagnostic agent of the invention is useful for evaluating the liver function of a subject at the time when the test is carried out.

    摘要翻译： 本发明涉及一种用于肝功能的诊断剂，其包含用13C标记的至少一个特定位置的化合物，所述化合物选自以下（a）至（f）：（a）标记的半乳糖，葡萄糖或木糖 13C至少在一个特定位置或由至少在一个特定位置用13C标记的葡萄糖单元组成的淀粉; （b）至少在一个特定位置用13C标记的极性氨基酸，杂环氨基酸，异亮氨酸或缬氨酸; （c）构成糖酵解途径或柠檬酸循环的羧酸，至少在一个特定位置用13C标记; （d）至少在一个特定位置用13C标记的脂肪酸; （e）至少在一个特定位置用13C标记的甘油酯; 和（f）至少在一个特定位置用13℃标记的甘油。 根据本发明，对受试者施加较少体力负荷的肝功能诊断剂可以立即给出准确的测试结果，并且可以安全使用而没有副作用。 本发明的诊断剂可用于评估在进行测试时受试者的肝功能。

    Diagnostic agent for diabetes
    7.
    发明授权
    Diagnostic agent for diabetes 失效
    糖尿病诊断剂

    公开(公告)号：US06509002B1

    公开(公告)日：2003-01-21

    申请号：US09176246

    申请日：1998-10-21

    申请人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Asuka Ito ,  Kunihiko Shibata

    发明人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Asuka Ito ,  Kunihiko Shibata

    IPC分类号： A61K5100

    CPC分类号： A61K51/1206 ,  A61K49/1815

    摘要： The present invention relates to a diagnostic agent for diabetes, comprising a compound labelled with 13C at least at one specific position selected from the group consisting of the following (a) to (g): (a) galactose, fructose or xylose labelled with 13C at least atone specific position, or a starch composed of glucose units labelled with 13C at least at one specific position; (b) an amino acid labelled with 13C at least at one specific position; (c) lactic acid or citric acid labelled with 13C at least at one specific position; (d) a fatty acid labelled with 13C at least at one specific position; (e) a glyceride labelled with 13C at least at one specific position; (f) glycerol labelled with 13C at least at one specific position; and (g) aminopyrin of which the dimethylamino group at position 4 is labelled with 13C, phenacetin of which the ethoxy group is labelled with 13C at position 1, or methacetin of which the methoxy group is labelled with 13C. According to the present invention, there is provided a diagnostic agent for diabetes which does not impose a heavy physical burden on a subject, can give accurate test results immediately and can be used safely without side effects. The diagnostic agent of the invention makes it possible to discriminate patients with diabetes from normal subjects even under circumstances where patients are easily missed.

    摘要翻译： 本发明涉及一种用于糖尿病的诊断剂，其包含用13C标记的至少一个特定位置的化合物，所述化合物选自以下（a）至（g）:( a）用13C标记的半乳糖，果糖或木糖 至少在一个特定位置，或由至少在一个特定位置用13C标记的葡萄糖单元组成的淀粉;（b）用13C至少在一个特定位置标记的氨基酸;（c）用13C标记的乳酸或柠檬酸 至少在一个具体位置;（d）至少在一个特定位置用13C标记的脂肪酸;（e）至少在一个特定位置用13C标记的甘油酯;（f）用13C标记的至少一个特定的 位置; 和（g）其中第4位的二甲氨基用13C标记的氨基吡啶，其中乙氧基被1位13C标记的非那西丁或甲氧基用13C标记的美沙西丁。根据本发明， 提供了不对受试者施加沉重的身体负担的糖尿病诊断剂，可以立即给出准确的测试结果，并且可以安全使用而没有副作用。 本发明的诊断剂即使在容易错过患者的情况下也能够将糖尿病患者与正常人区分开来。

    Reagent for evaluating a hepatic operation
    8.
    发明授权
    Reagent for evaluating a hepatic operation 失效
    用于评估肝脏手术的试剂

    公开(公告)号：US06174730B1

    公开(公告)日：2001-01-16

    申请号：US09151940

    申请日：1998-09-11

    申请人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Asuka Ito ,  Kunihiko Shibata

    发明人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Asuka Ito ,  Kunihiko Shibata

    IPC分类号： G01N3368

    CPC分类号： A61K51/1206 ,  A61K51/0402 ,  A61K51/0491 ,  Y10S436/811 ,  Y10S436/90

    摘要： The present invention relates to a reagent for evaluating a hepatic operation, comprising an aromatic amino acid, methionine, alanine, fructose or galactose labelled with 13C at least at one position. According to the present invention, there is provided a reagent for evaluating a hepatic operation, which imposes less physical burden on a subject, can give accurate test results immediately and can be used safely without side effects. The reagent of the invention is useful for measuring the accurate liver excision ratio, liver regeneration/increase ratio or liver weight of a subject after a hepatic operation. With the reagent of the invention, information which is useful for evaluating a hepatic operation and the degree of invasion by the operation and for diagnosis is provided.

    摘要翻译： 本发明涉及用于评估肝操作的试剂，其包含至少在一个位置用13 C标记的芳香族氨基酸，甲硫氨酸，丙氨酸，果糖或半乳糖。 根据本发明，提供了一种用于评价肝脏操作的试剂，其对受试者施加较少的身体负担，可以立即给出准确的测试结果，并且可以安全使用而没有副作用。 本发明的试剂可用于测量肝脏操作后受试者的精确肝切除率，肝脏再生/增加比例或肝脏重量。 利用本发明的试剂，提供了可用于评估肝脏操作和通过操作和诊断的入侵程度的信息。

    Diagnostic agents for pancreatic exocrine function
    10.
    发明授权
    Diagnostic agents for pancreatic exocrine function 失效
    胰腺外分泌功能诊断剂

    公开(公告)号：US06254851B1

    公开(公告)日：2001-07-03

    申请号：US09401739

    申请日：1999-09-23

    申请人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Kunihiko Shibata ,  Asuka Ito

    发明人： Tadashi Kohno ,  Isaburo Hosoi ,  Junko Ohshima ,  Kunihiko Shibata ,  Asuka Ito

    IPC分类号： A61K5100

    CPC分类号： A61K51/0491 ,  A61K49/06 ,  A61K49/1815 ,  A61K49/189 ,  A61K51/06 ,  A61K51/1206 ,  A61K51/1268 ,  B82Y5/00 ,  C08B37/00

    摘要： The present invention provides a 13C-labeled oligosaccharide or polysaccharide or a salt thereof excluding U-13C-maltose, 13C-starch, 1-13C-maltotetraose and 1-13C-amylose; a derivative of the 13C-labeled oligosaccharide or polysaccharide or salt thereof; a 13C-labeled inclusion complex or a salt thereof, which comprises a cyclodextrin or a modified derivative thereof as a host molecule; a 13C- or 14C-labeled fluorescein ester compound or a salt thereof; and a diagnostic agents for pancreatic exocrine function comprising these compounds 13C- or 14C-labeled.

    摘要翻译： 本发明提供除了U-13C-麦芽糖，13C-淀粉，1-13C-麦芽四糖和1-13C-直链淀粉以外的13C-标记的寡糖或多糖或其盐。 13 C-标记的寡糖或多糖或其盐的衍生物; 13 C-标记的包合物或其盐，其包含作为宿主分子的环糊精或其修饰的衍生物; 13C-或14C标记的荧光素酯化合物或其盐; 以及包含这些13C-或14C-标记的化合物的胰外分泌功能的诊断剂。