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    SMART CONTRAST AGENTS FOR MRI IMAGING
    1.
    发明申请
    SMART CONTRAST AGENTS FOR MRI IMAGING 审中-公开
    用于MRI成像的SMART对比剂

    公开(公告)号：US20110243857A1

    公开(公告)日：2011-10-06

    申请号：US13140360

    申请日：2009-12-18

    申请人： Geraldine Gouhier ,  Francois Estour

    发明人： Geraldine Gouhier ,  Francois Estour

    IPC分类号： A61K49/10 ,  C07F5/00 ,  C12Q1/02 ,  C07K2/00

    CPC分类号： A61K49/189 ,  A61K49/0002 ,  A61K49/085 ,  A61K49/12 ,  B82Y5/00

    摘要： A contrast agent for MRI imaging includes: (a) one cyclodextrin, whose truncated-cone-shaped structure defines a central axis, a first and a second openings along the axis, (b) one paramagnetic element, located on the cyclodextrin axis, outside the structure and proximate to the first opening, (c) one or several coordination ligand(s) of the paramagnetic element which coordinate(s) the paramagnetic element, (d) one arm covalently bound to the cyclodextrin, proximate to the second opening, which is able to form an inclusion complex with the cyclodextrin.

    摘要翻译： 用于MRI成像的造影剂包括：（a）一个环糊精，其截头锥形结构限定中心轴线，沿轴线的第一和第二开口，（b）位于环糊精轴上的一个顺磁元件，外部 所述结构并且靠近所述第一开口，（c）顺磁元件的一个或几个配位配体，其协调顺磁元件，（d）与所述环糊精共价结合的一个臂，靠近所述第二开口， 其能够与环糊精形成包合物。

    Cell-specific gene delivery vehicles
    2.
    发明授权
    Cell-specific gene delivery vehicles 失效
    细胞特异性基因递送载体

    公开(公告)号：US06962686B2

    公开(公告)日：2005-11-08

    申请号：US08541191

    申请日：1995-10-11

    申请人： Jon F. Kayyem ,  Thomas J. Meade ,  Scott E. Fraser

    发明人： Jon F. Kayyem ,  Thomas J. Meade ,  Scott E. Fraser

    IPC分类号： A61K49/12 ,  A61K51/00 ,  A61M36/14

    CPC分类号： A61K49/146 ,  A61K49/12 ,  A61K49/189 ,  B82Y5/00

    摘要： A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous physiological agents, particularly paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and physiological agents, including contrast agents and therapeutic agents, are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.

    摘要翻译： 描述了能够特异性结合并进入靶细胞的递送载体，递送许多生理剂，特别是顺磁离子用于细胞的磁共振成像（MRI）。 递送载体包含具有与具有净负电荷的另一个聚合物分子络合的净正电荷的聚合物分子。 细胞靶向部分和生理剂，包括造影剂和治疗剂，连接到一个或两个聚合物分子。 在一个实施方案中，具有净负电荷的聚合物分子是核酸。 因此，递送载体可以用于其中用于基因治疗的核酸和用于MRI对比的药剂共同转运到特定细胞的临床方案，允许核酸递送的医学成像监测。

    METHOD FOR COLLECTING METAL-CONTAINING FULLERENE
    5.
    发明申请
    METHOD FOR COLLECTING METAL-CONTAINING FULLERENE 有权
    用于收集含金属富勒烯的方法

    公开(公告)号：US20150246147A1

    公开(公告)日：2015-09-03

    申请号：US14380815

    申请日：2012-09-04

    申请人： Kazuhiko Akiyama ,  Tatsuyuki Hamano ,  Hisanori Shinohara ,  Yusuke Nakanishi

    发明人： Kazuhiko Akiyama ,  Tatsuyuki Hamano ,  Hisanori Shinohara ,  Yusuke Nakanishi

    IPC分类号： A61K51/12 ,  A61K49/18 ,  H01B1/04

    CPC分类号： A61K51/1268 ,  A61K49/189 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/152 ,  Y10S977/736 ,  Y10S977/845

    摘要： A method for recovering an endohedral metallofullerene comprises a complexation step of adding a Lewis acid comprising titanium halide or tin halide to a reaction solution formed by dissolving crude fullerenes in a solvent, thereby forming a complex of the endohedral metallofullerene and the Lewis acid, a filtering step of filtering the reaction solution to separate the complex, and a washing step of removing the Lewis acid from the complex to obtain the endohedral metallofullerene. The obtained endohedral metallofullerene is soluble in a solvent. This method provides a high recovery yield of the endohedral metallofullerene.

    摘要翻译： 回收内含金属富勒烯的方法包括将包含卤化钛或卤化锡的路易斯酸添加到通过将粗富勒烯溶解在溶剂中形成的反应溶液中的络合步骤，从而形成内嵌金属富勒烯和路易斯酸的络合物，过滤 过滤反应溶液以分离复合物的步骤，以及从络合物中除去路易斯酸以获得内嵌金属富勒烯的洗涤步骤。 所获得的内嵌金属富勒烯可溶于溶剂。 该方法提供了内向金属富勒烯的高回收率。

    Compositions useful for reducing toxicity associated with gadolinium-based contrast agents
    6.
    发明授权
    Compositions useful for reducing toxicity associated with gadolinium-based contrast agents 有权
    用于减少与钆基造影剂相关的毒性的组合物

    公开(公告)号：US08192721B2

    公开(公告)日：2012-06-05

    申请号：US12333168

    申请日：2008-12-11

    申请人： Vernon D. Rowe

    发明人： Vernon D. Rowe

    IPC分类号： A61B5/055

    CPC分类号： A61K49/189 ,  B82Y5/00

    摘要： The invention relates to compositions comprising a gadolinium-based contrast agent and a derivatized cyclodextrin. Further provided are methods for reducing the toxicity associated with gadolinium-based contrast agents.

    摘要翻译： 本发明涉及包含基于钆的造影剂和衍生的环糊精的组合物。 还提供了减少与钆基造影剂相关的毒性的方法。

    CARBON NANOHORN MRI CONTRAST AGENTS
    7.
    发明申请
    CARBON NANOHORN MRI CONTRAST AGENTS 审中-公开
    碳纳米星MRI对比剂

    公开(公告)号：US20120058053A1

    公开(公告)日：2012-03-08

    申请号：US13295621

    申请日：2011-11-14

    申请人： Sumio Iijima ,  Jin Miyawaki ,  Masako Yudasaka ,  Eiichi Nakamura ,  Hiroyuki Isobe ,  Hideki Yorimitsu ,  Hideto Imai

    发明人： Sumio Iijima ,  Jin Miyawaki ,  Masako Yudasaka ,  Eiichi Nakamura ,  Hiroyuki Isobe ,  Hideki Yorimitsu ,  Hideto Imai

    IPC分类号： A61B5/055 ,  B82Y5/00

    CPC分类号： A61K49/189 ,  A61B5/055 ,  B82Y5/00 ,  G01R33/281

    摘要： A contrast agent characterized in that each of carbon nanohorns forming a carbon nanohorn aggregate has an opening at the side wall or tip, wherein a metal M (at least one metal selected from among paramagnetic metals, ferromagnetic metals, and superparamagnetic metals) or a compound of the metal M is incorporated in or dispersed on each of the carbon nanohorns. A contrast agent characterized in that it contains a Gd oxide. There is provided a contrast agent, which can be mass-produced easily, and satisfies the requirement of low toxicity and enables microscopic diagnoses when used for MRI. A contrast agent characterized in that is contains a carbon nanohorn aggregate.

    摘要翻译： 一种造影剂，其特征在于，形成碳纳米角骨料的每个碳纳米角具有在侧壁或尖端处的开口，其中金属M（选自顺磁金属，铁磁性金属和超顺磁金属中的至少一种金属）或化合物 的金属M掺入或分散在每个碳纳米角上。 一种造影剂，其特征在于其含有Gd氧化物。 提供了可以容易地批量生产的造影剂，并且满足低毒性的要求并且在用于MRI时能够进行显微诊断。 其特征在于含有碳纳米角骨料的造影剂。