公开(公告)号：US20210332120A1

公开(公告)日：2021-10-28

申请号：US16097562

申请日：2016-12-02

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Dmitry Valentinovich MOROZOV ,  Andrei Borisovich ULITIN ,  Ekaterina Sergeevna ZUBAREVA ,  Iakov Iurevich USTIUGOV ,  Aleksandr Vladimirovich KARABELSKII ,  Dmitry Valeryevich KORZHAVIN ,  Tatiana Veniaminovna CHERNOVSKAYA ,  Aleksandr Valerevich GRACHEV ,  Yury Ivanovich BASOVSKIY ,  Ekaterina Aleksandrovna LOMKOVA ,  Veronika Sergeevna USATOVA ,  Aleksei Aleksandrovich ALEKSANDROV ,  Elena Leonidovna MOROZOVA ,  Roman Alekseevich IVANOV ,  Pavel Andreevich IAKOVLEV

IPC: C07K16/24 ,  A61P19/02 ,  A61K45/06 ,  A61K39/395

Abstract: The present invention relates to the field of biotechnology and provides monoclonal tri-specific binding molecules that specifically bind to human IL-17A, human IL-17F, and a human pro-inflammatory molecule (in particular, TNFα) with high affinity. The invention also relates to DNA constructs encoding said binding molecules, related expression vectors and methods of production, and methods of treatment using said binding molecules.

公开(公告)号：US20190127478A1

公开(公告)日：2019-05-02

申请号：US16095800

申请日：2017-07-04

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Viktoriia Mikhailovna EKIMOVA ,  Dmitry Valeryevich KORZHAVIN ,  Yulia Sergeevna CHERNYKH ,  Timofey Aleksandrovich NEMANKIN ,  Valery Vladimirovich SOLOVYEV ,  Anna Konstantinovna VLADIMIROVA ,  Irina Andreevna BULANKINA ,  Sergei Vasilyevich DIDUK ,  Olga Vladimirovna GONCHAROVA ,  Anna Vladimirovna EROSHOVA ,  Iakov Iurevich USTIUGOV ,  Marina Vladimirovna ARTIUKHOVA ,  Andrei Borisovich ULITIN ,  Roman Alekseevich IVANOV ,  Dmitry Valentinovich MOROZOV

IPC: C07K16/28 ,  A61P35/00 ,  C12N15/63 ,  A61P31/00

Abstract: The present invention relates to biotechnology and comprises isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind to PD-1 with high affinity. The antibodies according to the invention may be chimeric, humanized or human antibodies, or antigen-binding fragments thereof, and may be used as a medicinal agent in oncology and immuno-oncology, for treating diseases associated with various cell proliferation or development disorders. The invention also relates to methods for producing said antibodies and a method for treating human diseases using said antibodies.