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公开(公告)号：US20220112286A1
公开(公告)日：2022-04-14
申请号：US17417686
申请日：2020-02-20
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Olga Vladimirovna BRITANOVA , Dmitry Borisovich STAROVEROV , Anna Valentinovna EVSTRATEVA , Alexey Konstantinovich MISORIN , Timofey Aleksandrovich NEMANKIN , Mariia Aleksandrovna SHCHEMELEVA , Anna Konstantinovna VLADIMIROVA , Arina Vitalevna ANIKINA , Roman Alekseevich IVANOV , Dmitry Valentinovich MOROZOV , Pavel Andreevich IAKOVLEV , Sergey Anatolievich LUKYANOV
IPC: C07K16/28
Abstract: The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.
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Patent Agency Ranking
公开(公告)号：US20190127478A1
公开(公告)日：2019-05-02
申请号：US16095800
申请日：2017-07-04
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Viktoriia Mikhailovna EKIMOVA , Dmitry Valeryevich KORZHAVIN , Yulia Sergeevna CHERNYKH , Timofey Aleksandrovich NEMANKIN , Valery Vladimirovich SOLOVYEV , Anna Konstantinovna VLADIMIROVA , Irina Andreevna BULANKINA , Sergei Vasilyevich DIDUK , Olga Vladimirovna GONCHAROVA , Anna Vladimirovna EROSHOVA , Iakov Iurevich USTIUGOV , Marina Vladimirovna ARTIUKHOVA , Andrei Borisovich ULITIN , Roman Alekseevich IVANOV , Dmitry Valentinovich MOROZOV
Abstract: The present invention relates to biotechnology and comprises isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind to PD-1 with high affinity. The antibodies according to the invention may be chimeric, humanized or human antibodies, or antigen-binding fragments thereof, and may be used as a medicinal agent in oncology and immuno-oncology, for treating diseases associated with various cell proliferation or development disorders. The invention also relates to methods for producing said antibodies and a method for treating human diseases using said antibodies.
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公开(公告)号：US20200291121A1
公开(公告)日：2020-09-17
申请号：US16753488
申请日：2018-10-02
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Ekaterina Vladimirovna SOFRONOVA , Aleksei Konstantinovich MISORIN , Aleksandr Nikolaevich DORONIN , Timofey Aleksandrovich NEMANKIN , Aleksandra Aleksandrovna SOZONOVA , Galina Stepanovna ZHIRIVSKAIA , Sergey Aleksandrovich LEGOTSKY , Anna Konstantinovna VLADIMIROVA , Alina Valerevna BELIASNIKOVA , Mariia Aleksandrovna SHCHEMELEVA , Pavel Andreevich IAKOVLEV , Valery Vladimirovich SOLOVYEV , Elena Andreevna KRENDELEVA , Natalia Evgenevna PESTOVA , Dmitry Valentinovich MOROZOV
Abstract: The present invention relates to biotechnology and provides antibodies that specifically bind to IL-5Rα. The invention also relates to DNA encoding said antibodies, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibodies.
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4.发明申请公开(公告)号：US20190194313A1
公开(公告)日：2019-06-27
申请号：US16325528
申请日：2017-08-03
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Stanislav Rudolfovich EVDOKIMOV , Andrei Borisovich ULITIN , Valery Vladimirovich SOLOVYEV , Aleksei Aleksandrovich ALEKSANDROV , Yulia Sergeevna CHERNYKH , Timofey Aleksandrovich NEMANKIN , Anna Konstantinovna VLADIMIROVA , Oleg Igorevich SMOTROV , Tatiana Veniaminovna CHERNOVSKAYA , Aleksandr Aleksandrovich MOSHCHENKO , Viktoriia Evgenevna NALOBINA , Roman Alekseevich IVANOV , Dmitry Valentinovich MOROZOV
CPC classification number: C07K16/248 , A61K9/0073 , A61K9/19 , A61K39/395 , A61P37/00 , A61P37/06 , A61P37/08 , C07K16/065 , C07K16/18 , C07K16/24 , C12N15/00 , C12N15/63
Abstract: The invention relates to medicine. The problem addressed by the present invention consists in creating alternative antibodies or fragments thereof which are capable of specifically binding to a human receptor of interleukin-6 and which would be useful as drugs for treating or diagnosing diseases, or for relieving symptoms, mediated by interleukin-6.
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公开(公告)号：US20220056133A1
公开(公告)日：2022-02-24
申请号：US17417570
申请日：2019-12-24
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Olga Vladimirovna BRITANOVA , Dmitry Borisovich STAROVEROV , Anna Valentinovna EVSTRATEVA , Alexey Konstantinovich MISORIN , Timofey Aleksandrovich NEMANKIN , Mariia Aleksandrovna SHCHEMELEVA , Anna Konstantinovna VLADIMIROVA , Arina Vitalevna ANIKINA , Roman Alekseevich IVANOV , Dmitry Valentinovich MOROZOV , Pavel Andreevich IAKOVLEV , Sergey Anatolievich LUKYANOV
IPC: C07K16/28 , A61K45/06 , A61K39/395
Abstract: The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.
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公开(公告)号：US20200369771A1
公开(公告)日：2020-11-26
申请号：US16605865
申请日：2018-04-11
Applicant: JOINT STOCK COMPANY "BIOCAD"
Inventor： Andrey Borisovich ULITIN , Victoria Mikhailovna EKIMOVA , Ekaterina Vladimirovna SOFRONOVA, , Yulia Sergeevna CHERNYKH , Sergei Andreevich AGEEV , Anna Konstantinovna VLADIMIROVA , Aleksei Aleksandrovich ALEKSANDROV , Pavel Alekseevich GREBNEV , Valery Vladimirovich SOLOVYEV , Iakov Iurevich USTIUGOV , Pavel Andreevich IAKOVLEV , Timofey Aleksandrovich NEMANKIN , Dmitry Valentinovich MOROZOV
IPC: C07K16/28 , A61K45/06 , A61K39/395
Abstract: The present invention relates to the field of biotechnology and provides antibodies that specifically binds to PD-L1. The invention also relates to DNA encoding said antibodies, to corresponding expression vectors and to methods of producing, and to methods of treatment using said antibodies.
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