公开(公告)号：US20190127478A1

公开(公告)日：2019-05-02

申请号：US16095800

申请日：2017-07-04

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Viktoriia Mikhailovna EKIMOVA ,  Dmitry Valeryevich KORZHAVIN ,  Yulia Sergeevna CHERNYKH ,  Timofey Aleksandrovich NEMANKIN ,  Valery Vladimirovich SOLOVYEV ,  Anna Konstantinovna VLADIMIROVA ,  Irina Andreevna BULANKINA ,  Sergei Vasilyevich DIDUK ,  Olga Vladimirovna GONCHAROVA ,  Anna Vladimirovna EROSHOVA ,  Iakov Iurevich USTIUGOV ,  Marina Vladimirovna ARTIUKHOVA ,  Andrei Borisovich ULITIN ,  Roman Alekseevich IVANOV ,  Dmitry Valentinovich MOROZOV

IPC: C07K16/28 ,  A61P35/00 ,  C12N15/63 ,  A61P31/00

Abstract: The present invention relates to biotechnology and comprises isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind to PD-1 with high affinity. The antibodies according to the invention may be chimeric, humanized or human antibodies, or antigen-binding fragments thereof, and may be used as a medicinal agent in oncology and immuno-oncology, for treating diseases associated with various cell proliferation or development disorders. The invention also relates to methods for producing said antibodies and a method for treating human diseases using said antibodies.