公开(公告)号：US20240315984A1

公开(公告)日：2024-09-26

申请号：US18612755

申请日：2024-03-21

Applicant: Boston Scientific Scimed, Inc.

Inventor： Bhanu Prasanth Koppolu ,  Philip David Dorgan ,  Rhiannon Johnson ,  Steven L. Kangas ,  Nivedita Swetha Ramkumar ,  Matthew R. Dreher

IPC: A61K9/51 ,  A61K45/06

CPC classification number: A61K9/5153 ,  A61K9/5123 ,  A61K45/06

Abstract: The present disclosure pertains to biodegradable polymeric microspheres that comprise a biodegradable polymer and an immunotherapeutic agent selected from an inhibitor of poly ADP ribose polymerase enzyme (PARP inhibitor) and/or a Toll-like receptor (TLR) agonist wherein (a) 50% of a total amount of the immunotherapeutic agent in the biodegradable polymeric microspheres is released from the biodegradable polymeric microspheres into a 37° C. solution of PBS Tween 20 (0.05%) at a point in time ranging from 3 days and 14 days; (b) between 1 mg and 100 mg of immunotherapeutic agent per 1 g dry weight of microspheres is released from the biodegradable polymeric microspheres into a 37° C. solution of PBS Tween 20 (0.05%) at a point in time ranging from 3 days and 14 days; or (c) both (a) and (b). Other aspects of the present disclosure pertain to methods of using such microparticles and kits that contain such microparticles.

公开(公告)号：US11832830B2

公开(公告)日：2023-12-05

申请号：US17530031

申请日：2021-11-18

Applicant: Boston Scientific Scimed, Inc.

Inventor： Ajay Gupta ,  Daniel K. Tomaschko ,  Steven L. Kangas

IPC: A61B17/12 ,  A61L31/10 ,  A61L31/16 ,  A61B17/00

CPC classification number: A61B17/1215 ,  A61B17/12113 ,  A61L31/10 ,  A61L31/16 ,  A61B2017/00526 ,  A61B2017/00938 ,  A61B2017/00942 ,  A61L2300/418 ,  A61L31/10 ,  C08L39/06

Abstract: The present disclosure relates generally to devices, systems, and methods for coil embolization, and, more particularly, to use and methods of forming coated coils. In an aspect, an embolic system may include a coil having a proximal end, a distal end, and a length therebetween slidingly disposed within a sheath. A coating may be disposed about the coil. A delivery filament may be configured to be slidingly disposed within the sheath proximal of the coil such that the coil can be ejected from the distal end of the sheath into the working lumen of a microcatheter. The coating may be configured to substantially fracture as the coil transitions from being substantially aligned with a longitudinal axis of the microcatheter to substantially misaligned with the longitudinal axis of the microcatheter upon being ejected from the microcatheter. The coating may be configured to plasticize after being ejected into an aqueous environment.

公开(公告)号：US20160220490A1

公开(公告)日：2016-08-04

申请号：US14986774

申请日：2016-01-04

Applicant: Boston Scientific Scimed, Inc.

Inventor： Hongxia Zeng ,  Steven L. Kangas ,  Yen-Lane Chen

IPC: A61K9/16 ,  A61K49/00 ,  A61K31/337

CPC classification number: A61K9/1647 ,  A61K31/337 ,  A61K49/0091

Abstract: Polymer microspheres for embolizing blood vessels and optionally delivering therapeutic agents are provided. The microspheres include PLGA 50:50 and/or Ptx, and are generally formed by emulsion means.

Abstract translation: 提供用于栓塞血管和任选递送治疗剂的聚合物微球。 微球包括PLGA 50:50和/或Ptx，通常由乳液形成。