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![Substituted imidazo[1,2-b]pyridazines as interleukin-23 and interferon-α modulators](/abs-image/US/2022/04/12/US11299494B2/abs.jpg.150x150.jpg)
公开(公告)号：US11299494B2
公开(公告)日：2022-04-12
申请号：US16461479
申请日：2017-11-16
IPC分类号： A61K31/5025 , C07D487/04 , C07D519/00
摘要： Compounds of formula (I) or a stereoisomer or pharmaceutically-acceptable salt thereof, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
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公开(公告)号：US20210253554A1
公开(公告)日：2021-08-19
申请号：US17242428
申请日：2021-04-28
发明人： Chunjian Liu , Michael G. Yang , Zili Xiao , Ling Chen , Ryan M. Moslin , John S. Tokarski , David S. Weinstein , Stephen T. Wrobleski
IPC分类号： C07D401/14 , C07D401/12 , C07D413/14 , C07D471/04 , C07D405/14 , C07F9/6558 , C07D417/14 , A61P37/00 , A61P29/00 , A61K31/501 , C07D487/04
摘要： Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
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公开(公告)号：US11021462B2
公开(公告)日：2021-06-01
申请号：US16195951
申请日：2018-11-20
发明人： Chunjian Liu , Michael G. Yang , Zili Xiao , Ling Chen , Ryan M. Moslin , John S. Tokarski , David S. Weinstein , Stephen T. Wrobleski
IPC分类号： A61K31/395 , C07D401/14 , C07D401/12 , C07D413/14 , C07D471/04 , C07D405/14 , C07F9/6558 , C07D417/14 , A61P37/00 , A61P29/00 , A61K31/501 , C07D487/04
摘要： Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
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24.发明申请公开(公告)号：US20200071315A1
公开(公告)日：2020-03-05
申请号：US16687279
申请日：2019-11-18
发明人： Ryan M. Moslin , David S. Weinstein , Stephen T. Wrobleski , John S. Tokarski , Amit Kumar , Douglas G. Batt , Shuqun Lin , Chunjian Liu , Steven H. Spergel , Yanlei Yanlei , Qingjie Liu
IPC分类号： C07D417/14 , C07B59/00 , C07D417/12 , C07D413/12 , C07D403/14 , C07D237/24 , C07D401/12 , C07D413/14 , C07D401/14 , C07D403/12
摘要： Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
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25.发明申请公开(公告)号：US20180265504A1
公开(公告)日：2018-09-20
申请号：US15979770
申请日：2018-05-15
发明人： Ryan M. Moslin , David S. Weinstein , Stephen T. Wrobleski , John S. Tokarski , Amit Kumar , Douglas G. Batt , Shuqun Lin , Chunjian Liu , Steven H. Spergel , Yanlei Zhang , Qingjie Liu
IPC分类号： C07D417/14 , C07B59/00 , C07D417/12 , C07D413/12 , C07D403/12 , C07D237/24 , C07D401/12 , C07D413/14 , C07D401/14 , C07D403/14
摘要： Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
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26.发明授权公开(公告)号：US10000480B2
公开(公告)日：2018-06-19
申请号：US15289437
申请日：2016-10-10
发明人： Ryan M. Moslin , David S. Weinstein , Stephen T. Wrobleski , John S. Tokarski , Amit Kumar , Douglas G. Batt , Shuqun Lin , Chunjian Liu , Steven H. Spergel , Yanlei Zhang , Qingjie Liu
IPC分类号： C07D417/14 , C07D403/12 , C07D401/14 , C07D413/14 , C07D401/12 , C07D237/24 , C07D403/14 , C07D413/12 , C07D417/12 , C07B59/00
摘要： Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
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27.发明授权Alkyl amide-substituted pyrimidine compounds useful in the modulation of IL-12, IL-23 and/or IFNα 有权用于调节IL-12，IL-23和/或IFNα的烷基酰胺取代的嘧啶化合物公开(公告)号：US09540333B2
公开(公告)日：2017-01-10
申请号：US14441213
申请日：2013-11-07
发明人： Joseph B. Santella , Ryan M. Moslin , David S. Weinstein , Stephen T. Wrobleski , John S. Tokarski
IPC分类号： C07D239/48 , C07D239/95
CPC分类号： C07D239/48 , C07D239/95
摘要： Compounds having the following formula (I): or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα by acting on Tyk-2 to cause signal transduction inhibition.
摘要翻译： 具有下式（I）的化合物或其立体异构体或药学上可接受的盐，其中R 1，R 2，R 3，R 4和R 5如本文所定义，可用于调节IL-12，IL-23和/ 或通过作用于Tyk-2引起信号转导抑制的IFNα。
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28.发明授权Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNα responses 有权可用作IL-12，IL-23和/或IFNα应答调节剂的烷基酰胺取代的吡啶基化合物公开(公告)号：US09315494B2
公开(公告)日：2016-04-19
申请号：US14441193
申请日：2013-11-07
发明人： Ryan M. Moslin , Shuqun Lin , David S. Weinstein , Stephen T. Wrobleski , Yanlei Zhang , John S. Tokarski , Michael E. Mertzman
IPC分类号： C07D401/12 , A61K31/444 , C07D413/14 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要： Compounds having the following formula (I): or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
摘要翻译： 具有下式（I）的化合物或其立体异构体或药学上可接受的盐，其中R 1，R 2，R 3，R 4和R 5如本文所定义，可用于调节IL-12，IL-23和/ 或IFNα，通过作用于Tyk-2以引起信号转导抑制。
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29.发明申请ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES 有权用作IL-12，IL-23和/或IFN ALPHA反应的调节剂的烷基酰胺取代的吡啶化合物公开(公告)号：US20150307483A1
公开(公告)日：2015-10-29
申请号：US14441193
申请日：2013-11-07
发明人： Ryan M. Moslin , Shuqun Lin , David S. Weinstein , Stephen T. Wrobleski , Yanlei Zhang , John S. Tokarski , Michael E. Mertzman
IPC分类号： C07D413/14 , C07D401/14 , C07D401/12
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要： Compounds having the following formula (I): or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
摘要翻译： 具有下式（I）的化合物或其立体异构体或药学上可接受的盐，其中R 1，R 2，R 3，R 4和R 5如本文所定义，可用于调节IL-12，IL-23和/ 或IFNα，通过作用于Tyk-2以引起信号转导抑制。
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30.发明公开公开(公告)号：US20230167092A1
公开(公告)日：2023-06-01
申请号：US17997288
申请日：2021-04-27
发明人： Chunjian Liu , James Lin , David S. Weinstein
IPC分类号： C07D403/12 , C07D473/00 , C07D401/12 , C07D405/14 , C07D403/14 , C07D401/14 , C07D487/04 , C07D413/14
CPC分类号： C07D403/12 , C07D473/00 , C07D401/12 , C07D405/14 , C07D403/14 , C07D401/14 , C07D487/04 , C07D413/14 , C07B2200/05
摘要： There are disclosed compounds of the following formula I or a stereoisomer or pharmaceutically-acceptable salt thereof, wherein all substituents are as defined herein, which are useful in the modulation of IL-12, IL-23 and/or IFN?, by acting on Tyk-2 to cause signal transduction inhibition. The compounds of the invention may be useful for treating inflammatory and autoimmune diseases or disorders.
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