公开(公告)号：US07392295B2

公开(公告)日：2008-06-24

申请号：US10918086

申请日：2004-08-13

申请人： Chun Yuan ,  Jiahe Helen Wang ,  Yi-Min Wang ,  Zheng Zhang

发明人： Chun Yuan ,  Jiahe Helen Wang ,  Yi-Min Wang ,  Zheng Zhang

IPC分类号： G06F15/16

CPC分类号： H04L41/0853

摘要： A method and system for retrieving data from devices in a way that seeks to preserve privacy and ensure the integrity of the retrieved data is provided. A retrieval system is implemented on a network of devices that communicate with each other via a secure communications link. Each device is directly connected to one or more “friend” devices that it trusts. The retrieval system operates by forwarding a request for data from one friend device to another friend device. Each friend device may optionally add data to the request until all the requested data is added. The request with the retrieved data is returned to the device that initiated the request.

摘要翻译： 提供了以寻求保护隐私并确保检索的数据的完整性的方式从设备检索数据的方法和系统。 在通过安全通信链路彼此通信的设备网络上实现检索系统。 每个设备直接连接到它信任的一个或多个“朋友”设备。 检索系统通过将数据的请求从一个朋友设备转发到另一个朋友设备来操作。 每个朋友设备可以选择性地向请求中添加数据，直到添加所有请求的数据。 具有检索到的数据的请求将返回给发起请求的设备。

公开(公告)号：US20060184002A1

公开(公告)日：2006-08-17

申请号：US11385201

申请日：2006-03-21

申请人： Vasily Yarnykh ,  Chun Yuan

发明人： Vasily Yarnykh ,  Chun Yuan

IPC分类号： A61B5/05

CPC分类号： G01R33/5607 ,  G01R33/5601

摘要： A reduced field-of-view (FOV) imaging technique combines suppression of signals from outer volume and inflowing blood. Both outer volume and blood suppression are achieved using an SFQIR (Small-FOV Quadruple-inversion-Recovery) preparative pulse sequence including two double-inversion pulse pairs separated by appropriate delays. Within each pair, inversion pulses are successively applied to the imaged slice and the slab orthogonal to the imaging plane, with the thickness equal to the FOV size in the phase-encoding direction. Each double-inversion results in a reinversion of the magnetization in a central part of the FOV, while outer areas of the FOV and inflowing blood remain inverted. The SFQIR module was implemented for single-slice and multislice acquisition with a fast spin-echo readout sequence. Timing parameters of the sequence corresponding to the maximal suppression efficiency can be found by niiziig variation of the normalized signal over the entire range of T1 occurring in tissues.

摘要翻译： 减少的视野（FOV）成像技术结合了来自外部体积和流入血液的信号的抑制。 外部体积和血液抑制都使用包含两个双反转脉冲对的SFQIR（小FOV四重反转 - 恢复）制备脉冲序列来实现，该两个双反转脉冲对由适当的延迟分开。 在每对中，反转脉冲被连续施加到成像的切片和与成像平面垂直的平板，其厚度等于相位编码方向上的FOV大小。 每次双反转导致FOV中心部分的磁化反转，FOV和流入血液的外部区域保持反转。 SFQIR模块实现了具有快速自旋回波读出序列的单片和多分辨率采集。 对应于最大抑制效率的序列的定时参数可以通过归一化信号在组织中发生的整个T 1范围内的微分变化来发现。

公开(公告)号：US20050188048A1

公开(公告)日：2005-08-25

申请号：US10760441

申请日：2004-01-20

申请人： Chun Yuan ,  Zheng Zhang ,  Yu Chen

发明人： Chun Yuan ,  Zheng Zhang ,  Yu Chen

IPC分类号： G06F15/16 ,  G06F17/30 ,  H04L29/08

CPC分类号： G06F17/30902 ,  H04L67/2804 ,  H04L67/2814 ,  H04L67/2842 ,  H04L67/2852 ,  H04L69/329

摘要： Systems and methods for processing dynamic content are described herein. A system receives a request for content that includes an item cached by a proxy. The system issues another request to a content server to generate the other items that are not cached, without disrupting the process workflow of the original request. The system combines the items generated by the content server with the item cached by the proxy and sends the combined content to a destination.

摘要翻译： 本文描述了用于处理动态内容的系统和方法。 系统收到包含由代理缓存的项目的内容请求。 系统向内容服务器发出另一个请求，以生成未被缓存的其他项目，而不会中断原始请求的流程工作流程。 该系统将由内容服务器生成的项目与由代理缓存的项目组合，并将组合的内容发送到目的地。

公开(公告)号：US09709644B2

公开(公告)日：2017-07-18

申请号：US14112183

申请日：2012-04-12

申请人： Jinnan Wang ,  Peter Börnert ,  Chun Yuan

发明人： Jinnan Wang ,  Peter Börnert ,  Chun Yuan

IPC分类号： G01V3/00 ,  G01R33/30 ,  G01R33/563

CPC分类号： G01R33/30 ,  G01R33/56316 ,  G01R33/5635

摘要： A black blood magnetic resonance imaging sequence is performed using a magnetic resonance scanner. The sequence includes: applying a first flow sensitization gradient; applying a spoiler gradient after applying the first flow sensitization gradient; applying a second flow sensitization gradient after applying the spoiler gradient wherein the second flow sensitization gradient has area equal to the first flow sensitization gradient but of opposite polarity; applying a slice-selective radio frequency excitation pulse after applying the spoiler gradient; and performing a magnetic resonance readout after applying the second flow sensitization gradient and after applying the slice selective radio frequency excitation. The readout acquires magnetic resonance imaging data having blood signal suppression in the region excited by the slice-selective radio frequency excitation pulse. The magnetic resonance imaging data is suitably reconstructed to generate a black blood image that may be displayed.

公开(公告)号：US09523753B2

公开(公告)日：2016-12-20

申请号：US14112267

申请日：2012-04-13

申请人： Jinnan Wang ,  Michael Günter Helle ,  William Sean Kerwin ,  Peter Boernert ,  Chun Yuan

发明人： Jinnan Wang ,  Michael Günter Helle ,  William Sean Kerwin ,  Peter Boernert ,  Chun Yuan

IPC分类号： G01V3/00 ,  G01R33/563 ,  G01R33/56

CPC分类号： G01R33/5635 ,  G01R33/5602

摘要： Magnetic resonance (MR) spins are inverted by applying an inversion recovery (IR) radio frequency pulse (50). MR signals are acquired at an inversion time (TI) after the IR radio frequency pulse. TI is selected such that a first tissue of interest (e.g., blood) exhibits negative magnetism excited by the IR radio frequency pulse and a second tissue (e.g., intraplaque hemorrhage tissue) exhibits positive magnetism excited by the IR radio frequency pulse. The acquired magnetic resonance signals are reconstructed to generate spatial pixels or voxels wherein positive pixel or voxel values indicate spatial locations of positive magnetism and negative pixel or voxel values indicates spatial locations of negative magnetism. A first image (28) representative of the first tissue is generated from spatial pixels or voxels having negative signal intensities, and a second image (26) representative of the second tissue is generated from spatial pixels or voxels having positive signal intensities.

摘要翻译： 通过应用反转恢复（IR）射频脉冲（50）来反转磁共振（MR）自旋。 在IR射频脉冲之后，在反转时间（TI）获取MR信号。 选择TI，使得感兴趣的第一组织（例如血液）表现出由IR射频脉冲激发的负磁性，并且第二组织（例如，intraplaque出血组织）表现出由IR射频脉冲激发的正磁性。 所获取的磁共振信号被重建以产生空间像素或像素，其中正像素或体元值表示正磁性的空间位置，负像素或体素值表示负磁性的空间位置。 从具有负信号强度的空间像素或体素生成代表第一组织的第一图像（28），并且从具有正信号强度的空间像素或体素生成代表第二组织的第二图像（26）。

公开(公告)号：US08131336B2

公开(公告)日：2012-03-06

申请号：US11445510

申请日：2006-06-01

申请人： Fei Liu ,  William S Kerwin ,  Dongxiang Xu ,  Chun Yuan

发明人： Fei Liu ,  William S Kerwin ,  Dongxiang Xu ,  Chun Yuan

IPC分类号： A61B5/05

CPC分类号： A61B5/05 ,  A61B5/02007 ,  A61B5/7264 ,  G06T7/12 ,  G06T7/143 ,  G06T2207/10072 ,  G06T2207/30101

摘要： A method for the automated segmentation of in vivo image data is disclosed. A region of carotid artery in a number of patients was imaged using MRI. Histological data for each imaged region was then obtained, identifying various atherosclerotic plaque components in the imaged region. A portion of the histological data, and the image data, was used to generate PDFs based on image intensity, and on morphological data (local wall thickness and distance from lumen). The remaining data was used to validate the method. A plurality of MRI images were taken at various weightings, and the images were registered and normalized. The lumen and outer wall boundary were identified. The PDFs were combined in a Bayesian analysis with the intensity and morphological data to calculate the likelihood that each pixel corresponded to each of four plaque components. A contour algorithm was applied to generate contours segmenting the images by composition.

摘要翻译： 公开了一种用于体内图像数据的自动分割的方法。 使用MRI对许多患者的颈动脉区域进行成像。 然后获得每个成像区域的组织学数据，鉴定成像区域中的各种动脉粥样硬化斑块组分。 根据图像强度和形态学数据（局部壁厚和管腔距离），使用部分组织学资料和图像数据生成PDF。 剩余的数据用于验证方法。 以各种重量拍摄多个MRI图像，并对图像进行记录和归一化。 确定了管腔和外壁边界。 将PDF以贝叶斯分析与强度和形态数据组合，以计算每个像素对应于四个斑块组分中的每一个的可能性。 应用轮廓算法，通过组合生成轮廓分割图像。

公开(公告)号：US07962571B2

公开(公告)日：2011-06-14

申请号：US12044760

申请日：2008-03-07

申请人： Chun Yuan ,  Jiahe Helen Wang ,  Yi-Min Wang ,  Zheng Zhang

发明人： Chun Yuan ,  Jiahe Helen Wang ,  Yi-Min Wang ,  Zheng Zhang

IPC分类号： G06F15/16

CPC分类号： H04L41/0853

摘要： A method and system for retrieving data from devices in a way that seeks to preserve privacy and ensure the integrity of the retrieved data is provided. A retrieval system is implemented on a network of devices that communicate with each other via a secure communications link. Each device is directly connected to one or more “friend” devices that it trusts. The retrieval system operates by forwarding a request for data from one friend device to another friend device. Each friend device may optionally add data to the request until all the requested data is added. The request with the retrieved data is returned to the device that initiated the request.

摘要翻译： 提供了以寻求保护隐私并确保检索的数据的完整性的方式从设备检索数据的方法和系统。 在通过安全通信链路彼此通信的设备网络上实现检索系统。 每个设备直接连接到它信任的一个或多个“朋友”设备。 检索系统通过将数据的请求从一个朋友设备转发到另一个朋友设备来操作。 每个朋友设备可以选择性地向请求中添加数据，直到添加所有请求的数据。 具有检索到的数据的请求将返回给发起请求的设备。

公开(公告)号：US07627359B2

公开(公告)日：2009-12-01

申请号：US11385201

申请日：2006-03-21

申请人： Vasily L. Yarnykh ,  Chun Yuan

发明人： Vasily L. Yarnykh ,  Chun Yuan

IPC分类号： A61B5/05

CPC分类号： G01R33/5607 ,  G01R33/5601

摘要： A reduced field-of-view (FOV) imaging technique combines suppression of signals from outer volume and inflowing blood. Both outer volume and blood suppression are achieved using an SFQIR (Small-FOV Quadruple-inversion-Recovery) preparative pulse sequence including two double-inversion pulse pairs separated by appropriate delays. Within each pair, inversion pulses are successively applied to the imaged slice and the slab orthogonal to the imaging plane, with the thickness equal to the FOV size in the phase-encoding direction. Each double-inversion results in a reinversion of the magnetization in a central part of the FOV, while outer areas of the FOV and inflowing blood remain inverted. The SFQIR module was implemented for single-slice and multislice acquisition with a fast spin-echo readout sequence. Timing parameters of the sequence corresponding to the maximal suppression efficiency can be found by minimizing variation of the normalized signal over the entire range of T1 occurring in tissues.

摘要翻译： 减少的视野（FOV）成像技术结合了来自外部体积和流入血液的信号的抑制。 外部体积和血液抑制都使用包含两个双反转脉冲对的SFQIR（小FOV四重反转 - 恢复）制备脉冲序列来实现，该两个双反转脉冲对由适当的延迟分开。 在每对中，反转脉冲被连续施加到成像的切片和与成像平面垂直的平板，其厚度等于相位编码方向上的FOV大小。 每次双反转导致FOV中心部分的磁化反转，FOV和流入血液的外部区域保持反转。 SFQIR模块实现了具有快速自旋回波读出序列的单片和多分辨率采集。 可以通过最小化在组织中发生的T1的整个范围内的归一化信号的变化来找到对应于最大抑制效率的序列的定时参数。

公开(公告)号：US07590704B2

公开(公告)日：2009-09-15

申请号：US10760441

申请日：2004-01-20

申请人： Chun Yuan ,  Zheng Zhang ,  Yu Chen

发明人： Chun Yuan ,  Zheng Zhang ,  Yu Chen

IPC分类号： G06F15/16

CPC分类号： G06F17/30902 ,  H04L67/2804 ,  H04L67/2814 ,  H04L67/2842 ,  H04L67/2852 ,  H04L69/329

摘要： Systems and methods for processing dynamic content are described herein. A system receives a request for content that includes an item cached by a proxy. The system issues another request to a content server to generate the other items that are not cached, without disrupting the process workflow of the original request. The system combines the items generated by the content server with the item cached by the proxy and sends the combined content to a destination.

摘要翻译： 本文描述了用于处理动态内容的系统和方法。 系统收到包含由代理缓存的项目的内容请求。 系统向内容服务器发出另一个请求，以生成未被缓存的其他项目，而不会中断原始请求的流程工作流程。 该系统将由内容服务器生成的项目与由代理缓存的项目组合，并将组合的内容发送到目的地。

公开(公告)号：US07340083B2

公开(公告)日：2008-03-04

申请号：US11172415

申请日：2005-06-29

申请人： Chun Yuan ,  Thomas S. Hatsukami ,  Renu Virmani ,  Jianming Cai ,  William S. Kerwin ,  Marina S. Ferguson

发明人： Chun Yuan ,  Thomas S. Hatsukami ,  Renu Virmani ,  Jianming Cai ,  William S. Kerwin ,  Marina S. Ferguson

IPC分类号： G06K9/00 ,  G06F7/60 ,  G06F17/10

CPC分类号： G06T7/0012 ,  A61B5/02007 ,  A61B5/055 ,  A61B5/7275 ,  A61B6/504 ,  A61B8/0833 ,  G06F19/00 ,  G06T2207/30101

摘要： A method for characterizing the risk associated with atherosclerosis is disclosed. The method uses one or more images of cross-sections of the artery or other vessel of interest to identify and locate components of the atherosclerotic deposit, including any hemorrhage, necrotic core, and calcification, and to determine the status and composition of the fibrous cap. In one embodiment, high resolution MRI images are utilized, although other imaging modalities may alternatively be used. A simple scoring system is applied that accounts for the presence of these components and more heavily weights the presence of these components in the juxtaluminal portion of the deposit. The status of the fibrous cap (intact or ruptured) and the composition of the fibrous cap (collagen or mixed tissue) are also incorporated into a final atherosclerosis risk score.

摘要翻译： 公开了描述与动脉粥样硬化相关的风险的方法。 该方法使用动脉或其他所需血管的横截面的一个或多个图像来识别和定位动脉粥样硬化沉积物的组分，包括任何出血，坏死核心和钙化，并确定纤维帽的状态和组成 。 在一个实施例中，利用了高分辨率MRI图像，但是也可以使用其它成像模式。 应用一个简单的评分系统来解释这些组件的存在，并且更重地将这些组件的存在权重存放在存款的两个部分中。 纤维帽（完整或破裂）的状态和纤维帽（胶原蛋白或混合组织）的组成也被纳入最终的动脉粥样硬化风险评分。