公开(公告)号：US20170056388A1

公开(公告)日：2017-03-02

申请号：US15257275

申请日：2016-09-06

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Andrew Cook ,  Les A. Dakin ,  Martin Duplessis ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Christopher G. Nasveschuk ,  Rishi G. Vaswani

IPC: A61K31/4545

CPC classification number: A61K31/4545 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/06 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

Abstract translation: 本文提供了用于调节甲基修饰酶的组合物及其用途。

公开(公告)号：US09522920B2

公开(公告)日：2016-12-20

申请号：US14313148

申请日：2014-06-24

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Alexandre Côté ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Michael Charles Hewitt ,  Yves Leblanc ,  Christopher G. Nasveschuk ,  Alexander M. Taylor ,  Rishi G. Vaswani

IPC: A61K31/55 ,  C07D498/04 ,  C07D498/14 ,  C07D498/20 ,  C07D498/22 ,  C07K14/47 ,  A61K31/424

CPC classification number: C07D498/04 ,  A61K31/424 ,  A61K31/55 ,  C07D498/14 ,  C07D498/20 ,  C07D498/22 ,  C07K14/4702

Abstract: The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.

公开(公告)号：US20160333016A1

公开(公告)日：2016-11-17

申请号：US15155749

申请日：2016-05-16

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Andrew Cook ,  Les A. Dakin ,  Martin Duplessis ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Christopher G. Nasveschuk ,  Rishi G. Vaswani

IPC: C07D487/04 ,  C07D405/14 ,  C07D401/14 ,  C07D401/12 ,  C07D471/04

CPC classification number: A61K31/4545 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/06 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

公开(公告)号：US20160317632A1

公开(公告)日：2016-11-03

申请号：US15095985

申请日：2016-04-11

Applicant: GENENTECH, INC. ,  CONSTELLATION PHARMACEUTICALS, INC.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Steven Bellon ,  Andrea Cochran ,  Alexandre Cote ,  Terry Crawford ,  Benjamin Fauber ,  Srimoyee Ghosh ,  Jean-Christophe Harmange ,  Georgia Hatzivassiliou ,  Hariharan Jayaram ,  Jeong Kim ,  Jose M. Lora ,  Steven Magnuson ,  Ira Mellman ,  Anthony F. Romero ,  Alexander M. Taylor ,  Vickie Tsui

IPC: A61K39/00 ,  A61K31/498 ,  G01N33/50 ,  A61K31/538

CPC classification number: A61K39/0011 ,  A61K31/498 ,  A61K31/538 ,  C07K14/475 ,  G01N33/5011

Abstract: The present invention relates to use of CBP/EP300 bromodomain inhibitors for the treatment of cancer.

Abstract translation: 本发明涉及CBP / EP300溴结构域抑制剂用于治疗癌症的用途。

公开(公告)号：US09371331B2

公开(公告)日：2016-06-21

申请号：US14661797

申请日：2015-03-18

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Andrew S. Cook ,  Les A. Dakin ,  Martin Duplessis ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Christopher G. Nasveschuk ,  Rishi G. Vaswani

IPC: A61K31/535 ,  C07D401/00 ,  C07D487/04 ,  C07D401/14 ,  C07D401/12 ,  C07D417/04 ,  C07D417/14 ,  C07D405/14 ,  C07D409/06 ,  C07D471/04

CPC classification number: A61K31/4545 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/06 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

公开(公告)号：US09206128B2

公开(公告)日：2015-12-08

申请号：US14358558

申请日：2012-11-19

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Andrew S. Cook ,  Alexandre Gagnon ,  Jean-Christophe Harmange ,  Christopher G. Nasveschuk

IPC: C07D213/61 ,  C07D213/64 ,  C07D221/18 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

CPC classification number: C07D213/64 ,  C07D221/18 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12

Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

公开(公告)号：US09051269B2

公开(公告)日：2015-06-09

申请号：US14358455

申请日：2012-11-19

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Alexandre Gagnon ,  Jean-Christophe Harmange ,  Christopher G. Nasveschuk

IPC: C07D213/62 ,  C07D213/64 ,  C07D405/12 ,  C07D401/12

CPC classification number: C07D213/64 ,  C07D213/81 ,  C07D401/12 ,  C07D405/12

Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

Abstract translation: 本文提供了用于调节甲基修饰酶的组合物及其用途。

公开(公告)号：USRE47428E1

公开(公告)日：2019-06-11

申请号：US15878663

申请日：2018-01-24

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Les A. Dakin ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Christopher G. Nasveschuk ,  Rishi G. Vaswani

IPC: C07D401/12 ,  C07D401/14 ,  C07D487/04 ,  C07D417/04 ,  C07D417/14 ,  C07D405/14 ,  C07D471/04 ,  C07D409/06 ,  A61K31/4545

Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

公开(公告)号：US20190125737A1

公开(公告)日：2019-05-02

申请号：US15994005

申请日：2018-05-31

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Andrew Cook ,  Les A. Dakin ,  Martin Duplessis ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Christopher G. Nasveschuk ,  Rishi G. Vaswani

IPC: A61K31/4545 ,  C07D471/04 ,  C07D409/06 ,  C07D405/14 ,  C07D401/14 ,  C07D487/04 ,  C07D417/04 ,  C07D401/12 ,  C07D417/14

Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

公开(公告)号：US20180327386A1

公开(公告)日：2018-11-15

申请号：US15755854

申请日：2016-08-25

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  Alisha Arrigo ,  Donald Corson ,  Victor S. Gehling ,  Bruno Patrice Haché ,  Jean-Christophe Harmange ,  Jonathan Lane

IPC: C07D401/14

CPC classification number: C07D401/14 ,  C07B2200/13

Abstract: The present disclosure relates to a crystalline Forms A, B, and C of (R)—N-((4-methoxy-6-methyl-2-oxo-1,2-di-hydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide, each of which are useful as modulators the activity of histone methyl modifying enzymes. The present disclosure also provides pharmaceutically acceptable compositions comprising the crystalline forms and methods of using said compositions in the treatment of various disorders.