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公开(公告)号：US09371331B2
公开(公告)日：2016-06-21
申请号：US14661797
申请日：2015-03-18
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew S. Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: A61K31/535 , C07D401/00 , C07D487/04 , C07D401/14 , C07D401/12 , C07D417/04 , C07D417/14 , C07D405/14 , C07D409/06 , C07D471/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：USRE47428E1
公开(公告)日：2019-06-11
申请号：US15878663
申请日：2018-01-24
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Les A. Dakin , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D401/12 , C07D401/14 , C07D487/04 , C07D417/04 , C07D417/14 , C07D405/14 , C07D471/04 , C07D409/06 , A61K31/4545
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US20190125737A1
公开(公告)日：2019-05-02
申请号：US15994005
申请日：2018-05-31
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: A61K31/4545 , C07D471/04 , C07D409/06 , C07D405/14 , C07D401/14 , C07D487/04 , C07D417/04 , C07D401/12 , C07D417/14
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US10016405B2
公开(公告)日：2018-07-10
申请号：US15257275
申请日：2016-09-06
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: A61K31/4545 , C07D401/14 , C07D401/12 , C07D417/04 , C07D487/04 , C07D417/14 , C07D405/14 , C07D409/06 , C07D471/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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25.发明授权公开(公告)号：US09969716B2
公开(公告)日：2018-05-15
申请号：US14911343
申请日：2014-08-15
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D401/14 , C07D401/12 , C07D405/14 , C07D413/14
CPC classification number: C07D401/14 , C07D401/12 , C07D405/14 , C07D413/14
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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Patent Agency Ranking
公开(公告)号：US20180037568A1
公开(公告)日：2018-02-08
申请号：US15549265
申请日：2016-02-04
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , Victor S. Gehling , Jean-Christophe Harmange , Rishi G. Vaswani
IPC: C07D401/14 , C07D405/14
CPC classification number: C07D401/14 , C07D405/14
Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.
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公开(公告)号：US09745305B2
公开(公告)日：2017-08-29
申请号：US14769471
申请日：2014-03-12
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Alexandre Côté , Les A. Dakin , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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![Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof](/abs-image/US/2017/04/18/US09624244B2/abs.jpg.150x150.jpg)
公开(公告)号：US09624244B2
公开(公告)日：2017-04-18
申请号：US14405211
申请日：2013-06-06
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , Victor S. Gehling , Alexander M. Taylor , Rishi G. Vaswani
IPC: A61K31/55 , C07D498/04 , C07D498/10
CPC classification number: C07D498/10 , A61K31/55 , C07D498/04
Abstract: The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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![Benzo [C] isoxazoloazepine bromodomain inhibitors and uses thereof](/abs-image/US/2016/11/15/US09493483B2/abs.jpg.150x150.jpg)
29.发明授权公开(公告)号：US09493483B2
公开(公告)日：2016-11-15
申请号：US14405209
申请日：2013-06-06
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , Michael Charles Hewitt , Victor S. Gehling , Rishi G. Vaswani
IPC: A61K31/55 , C07D498/04
CPC classification number: A61K31/55 , C07D498/04
Abstract: The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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30.发明申请INDOLE DERIVATIVES AS MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF 有权作为甲基修饰酶的调节剂的吲哚衍生物，其组合物及其用途公开(公告)号：US20160185757A1
公开(公告)日：2016-06-30
申请号：US14911343
申请日：2014-08-15
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D401/14 , C07D413/14 , C07D405/14
CPC classification number: C07D401/14 , C07D401/12 , C07D405/14 , C07D413/14
Abstract: Agents of formulas (I)/(II)/(III) for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
Abstract translation: 本文提供了用于调节甲基修饰酶的式（I）/（II）/（III）的试剂，其组合物和用途。
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