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公开(公告)号：US08492553B2
公开(公告)日：2013-07-23
申请号：US13606231
申请日：2012-09-07
申请人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号： C07D233/00 , C07D233/02 , A01N43/50 , A61K31/415
CPC分类号： C07D403/14 , A61K31/4178 , A61K31/4545 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07F7/10
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号：US20080044380A1
公开(公告)日：2008-02-21
申请号：US11835524
申请日：2007-08-08
申请人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号： A61K31/415 , A61K31/16 , A61K31/4178 , A61K31/44 , A61K31/4965 , A61K31/7056 , A61K31/711 , A61K38/21 , A61K45/00 , C07D233/64 , C07D401/14 , C07D403/14
CPC分类号： C07D403/14 , A61K31/4178 , A61K31/4545 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07F7/10
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号：US07659270B2
公开(公告)日：2010-02-09
申请号：US11835485
申请日：2007-08-08
申请人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
发明人： Carol Bachand , Makonen Belema , Daniel H. Deon , Andrew C. Good , Jason Goodrich , Clint A. James , Rico Lavoie , Omar D. Lopez , Alain Martel , Nicholas A. Meanwell , Van N. Nguyen , Jeffrey Lee Romine , Edward H. Ruediger , Lawrence B. Snyder , Denis R. St. Laurent , Fukang Yang , David R. Langley , Lawrence G. Hamann
IPC分类号： A61K31/4178 , A61K31/4196 , A61K31/4245 , A61K31/426 , A61K31/4353 , A61K31/4427 , C07D213/02 , C07D295/00 , C07D277/02 , C07D249/08 , C07D241/02 , C07D239/02
CPC分类号： C07D401/14 , C07D403/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号：US20130012540A1
公开(公告)日：2013-01-10
申请号：US13611708
申请日：2012-09-12
申请人： Rico Lavoie , John A. Bender , Jeffrey Lee Romine , Edward H. Ruediger , Carol Bachand , Omar D. Lopez , Qi Chen , Makonen Belema , John F. Kadow , Lawrence G. Hamann
发明人： Rico Lavoie , John A. Bender , Jeffrey Lee Romine , Edward H. Ruediger , Carol Bachand , Omar D. Lopez , Qi Chen , Makonen Belema , John F. Kadow , Lawrence G. Hamann
IPC分类号： A61K31/4178 , C07D417/14 , A61K31/427 , C07D413/14 , A61P31/14 , C07D403/14 , C07D401/14 , A61K31/4545 , C07D407/14 , C07D409/14 , A61K31/422
CPC分类号： C07D417/14 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/10 , C07D419/10 , C07D493/08
摘要： This disclosure concerns novel compounds of Formula (I) or as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.
摘要翻译： 本公开涉及式（I）的新化合物或说明书中定义的和包含这些新化合物的组合物。 这些化合物是有用的抗病毒剂，特别是抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能。 因此，本公开还涉及通过使用这些新化合物或包含这些新化合物的组合物治疗HCV相关疾病或病症的方法。
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公开(公告)号：US20110281910A1
公开(公告)日：2011-11-17
申请号：US12942183
申请日：2010-11-09
申请人： Rico Lavoie , John A. Bender , Jeffrey Lee Romine , Edward H. Ruediger , Carol Bachand , Omar D. Lopez , Qi Chen , Makonen Belema , John F. Kadow , Lawrence G. Hamann
发明人： Rico Lavoie , John A. Bender , Jeffrey Lee Romine , Edward H. Ruediger , Carol Bachand , Omar D. Lopez , Qi Chen , Makonen Belema , John F. Kadow , Lawrence G. Hamann
IPC分类号： A61K31/4178 , C07D417/14 , C07D413/14 , C07D403/14 , A61P31/14 , C07D407/14 , A61K31/427 , A61K31/422 , A61K31/4545 , C07D409/14 , C07D401/14
CPC分类号： C07D417/14 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/10 , C07D419/10 , C07D493/08
摘要： This disclosure concerns novel compounds of Formula (I) or as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.
摘要翻译： 本公开涉及式（I）的新化合物或说明书中定义的和包含这些新化合物的组合物。 这些化合物是有用的抗病毒剂，特别是抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能。 因此，本公开还涉及通过使用这些新化合物或包含这些新化合物的组合物治疗HCV相关疾病或病症的方法。
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26.发明申请公开(公告)号：US20080188481A1
公开(公告)日：2008-08-07
申请号：US12015767
申请日：2008-01-17
申请人： Tao Wang , John F. Kadow , Nicholas A. Meanwell , Kap-Sun Yeung , Zhongxing Zhang , Zhiwei Yin , Zhilei Qiu , Daniel H. Deon , Clint A. James , Edward H. Ruediger , Carol Bachand
发明人： Tao Wang , John F. Kadow , Nicholas A. Meanwell , Kap-Sun Yeung , Zhongxing Zhang , Zhiwei Yin , Zhilei Qiu , Daniel H. Deon , Clint A. James , Edward H. Ruediger , Carol Bachand
IPC分类号： A61K31/497 , A61K31/4523 , A61K31/506 , A61P31/18 , A61K31/437
CPC分类号： C07D401/06 , C07D413/14 , C07D471/04
摘要： This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: wherein: Z is Q is selected from the group consisting of: —W— is
摘要翻译： 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本发明涉及具有独特抗病毒活性的新的哌啶-4-链烯基衍生物。 更具体地，本发明涉及可用于治疗HIV和AIDS的化合物。 用于通式I的本发明化合物：其中：Z是Q选自：-W-是
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27.发明授权公开(公告)号：US07915283B2
公开(公告)日：2011-03-29
申请号：US12015767
申请日：2008-01-17
申请人： Tao Wang , John F. Kadow , Nicholas A. Meanwell , Kap-Sun Yeung , Zhongxing Zhang , Zhiwei Yin , Zhilei Qui , Daniel H. Deon , Clint A. James , Edward H. Ruediger , Carol Bachand
发明人： Tao Wang , John F. Kadow , Nicholas A. Meanwell , Kap-Sun Yeung , Zhongxing Zhang , Zhiwei Yin , Zhilei Qui , Daniel H. Deon , Clint A. James , Edward H. Ruediger , Carol Bachand
IPC分类号： A61K31/454 , A61K31/4545
CPC分类号： C07D401/06 , C07D413/14 , C07D471/04
摘要： This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: wherein: Z is Q is selected from the group consisting of: —W— is
摘要翻译： 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本发明涉及具有独特抗病毒活性的新的哌啶-4-链烯基衍生物。 更具体地，本发明涉及可用于治疗HIV和AIDS的化合物。 用于通式I的本发明化合物：其中：Z是Q选自：-W-是
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28.发明授权公开(公告)号：US07348337B2
公开(公告)日：2008-03-25
申请号：US10762108
申请日：2004-01-21
申请人： Tao Wang , John F. Kadow , Nicholas A. Meanwell , Kap-Sun Yeung , Zhongxing Zhang , Zhiwei Yin , Zhilei Qiu , Daniel H. Deon , Clint A. James , Edward H. Ruediger , Carol Bachand
发明人： Tao Wang , John F. Kadow , Nicholas A. Meanwell , Kap-Sun Yeung , Zhongxing Zhang , Zhiwei Yin , Zhilei Qiu , Daniel H. Deon , Clint A. James , Edward H. Ruediger , Carol Bachand
IPC分类号： A61K31/454 , A61K31/4545 , C07D471/04 , C07D401/06
CPC分类号： C07D401/06 , C07D413/14 , C07D471/04
摘要： This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: wherein: Z is Q is selected from the group consisting of: —W— is
摘要翻译： 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本发明涉及具有独特抗病毒活性的新的哌啶-4-链烯基衍生物。 更具体地，本发明涉及可用于治疗HIV和AIDS的化合物。 用于通式I的本发明化合物：其中：Z是Q选自：-W-是
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公开(公告)号：US20070249624A1
公开(公告)日：2007-10-25
申请号：US11737354
申请日：2007-04-19
IPC分类号： A61K31/496 , C07D403/02 , C07D471/02
CPC分类号： C07D209/14 , C07D209/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with 4-squarylpiperazine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS.
摘要翻译： 本公开提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本公开涉及具有独特抗病毒活性的4-顺式哌嗪衍生物。 更具体地，本公开涉及可用于治疗HIV和AIDS的化合物。
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公开(公告)号：US07501419B2
公开(公告)日：2009-03-10
申请号：US11737354
申请日：2007-04-19
IPC分类号： A61K31/496 , C07D295/192 , C07D403/12 , C07D405/12 , C07D487/04
CPC分类号： C07D209/14 , C07D209/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with 4-squarylpiperazine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS having the following formula:
摘要翻译： 本公开提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本公开涉及具有独特抗病毒活性的4-顺式哌嗪衍生物。 更具体地说，本公开内容涉及可用于治疗具有以下结构式的HIV和AIDS的化合物：
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