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    Injection device
    21.
    发明授权
    Injection device 有权

    公开(公告)号：US10265478B2

    公开(公告)日：2019-04-23

    申请号：US13497773

    申请日：2010-09-29

    申请人： Garen Kouyoumjian ,  Robert Veasey ,  David Plumptre ,  Christopher Jones ,  Catherine Anne MacDonald ,  James May

    发明人： Garen Kouyoumjian ,  Robert Veasey ,  David Plumptre ,  Christopher Jones ,  Catherine Anne MacDonald ,  James May

    IPC分类号： A61M5/315 ,  A61M5/24 ,  A61M5/31

    摘要： An injection device (1) for administering a fixed dose of a medication is provided. The injection device (1) comprises a housing (2) wherein a drive mechanism comprising a drive member (3) is at least partially enclosed and a dosing element (34) which is fixed relative to the drive member (3). Here, a dose can be set by rotating the dosing element (34) relative to the housing (2) in a dose set direction (105) and the dose can be dispensed by pushing the dosing element (34) towards the housing (2). Moreover, a method is provided for operating an injection device (1) for the administration of a fixed dose of a medication: A dose can be set by rotating a dosing element (34), a dose can be dispensed by pushing the dosing element (34) towards the housing (2) and a dose can be cancelled by rotating the dosing element (34) in a direction (106) opposite to the dose set direction (105).

    Drug delivery device, assembly for a drug delivery device and method for setting up a drug delivery device
    22.
    发明授权
    Drug delivery device, assembly for a drug delivery device and method for setting up a drug delivery device 有权
    药物递送装置，用于药物递送装置的组装和用于设置药物递送装置的方法

    公开(公告)号：US09555192B2

    公开(公告)日：2017-01-31

    申请号：US13497376

    申请日：2010-09-29

    申请人： Catherine Anne Macdonald ,  Robert Veasey ,  Garen Kouyoumjian ,  Christopher Jones ,  Alexander Ian Bailey

    发明人： Catherine Anne Macdonald ,  Robert Veasey ,  Garen Kouyoumjian ,  Christopher Jones ,  Alexander Ian Bailey

    IPC分类号： A61M5/00 ,  A61M5/24 ,  A61M5/31 ,  A61M5/315 ,  A61M5/20

    CPC分类号： A61M5/24 ,  A61M5/2448 ,  A61M5/3146 ,  A61M5/31571 ,  A61M5/31578 ,  A61M2005/2073 ,  A61M2005/2451

    摘要： The instant application is directed to an assembly for a drug delivery device which is arranged to operate in two distinct modes, a priming mode starting from a pre-priming state and a dispense mode operating in a post-priming state, and a drug delivery device comprising this assembly. The assembly comprises a dose member, an actuating member and a piston rod which is configured to act on a bung of an assembled cartridge containing the drug. In the pre-priming state the actuating member is configured to be moved by a user such that the movement of the actuating member causes a movement of the dose member and such that the movement of the dose member causes a movement of the piston rod. In the post-priming state the dose member is configured to be moved by a user without causing a movement of the actuating member in order to perform a set and dispense action of the drug delivery device.

    摘要翻译： 本申请涉及用于药物递送装置的组件，其被布置成以两种不同模式操作，从预灌注状态开始的启动模式和以后启动状态操作的分配模式，以及药物递送装置 包括该组件。 组件包括剂量构件，致动构件和活塞杆，其构造成作用在装有药物的组装好的药筒的栓上。 在预灌注状态下，致动构件被构造成由使用者移动，使得致动构件的移动导致剂量构件的运动，并且使得剂量构件的移动导致活塞杆的移动。 在后启动状态中，剂量构件被构造成由使用者移动而不引起致动构件的移动，以便执行药物递送装置的集合和分配动作。

    Injection Device
    23.
    发明申请
    Injection Device 审中-公开
    注射装置

    公开(公告)号：US20120310206A1

    公开(公告)日：2012-12-06

    申请号：US13497773

    申请日：2010-09-29

    申请人： Garen Kouyoumjian ,  Robert Veasey ,  David Plumptre ,  Christopher Jones ,  Catherine Anne MacDonald ,  James May

    发明人： Garen Kouyoumjian ,  Robert Veasey ,  David Plumptre ,  Christopher Jones ,  Catherine Anne MacDonald ,  James May

    IPC分类号： A61M5/315

    CPC分类号： A61M5/31543 ,  A61M5/24 ,  A61M5/3129 ,  A61M5/31525 ,  A61M5/31541 ,  A61M5/31551 ,  A61M5/31558 ,  A61M5/3156 ,  A61M5/31585 ,  A61M2005/2407 ,  A61M2005/2488 ,  A61M2205/581 ,  A61M2205/582

    摘要： An injection device (1) for administering a fixed dose of a medication is provided. The injection device (1) comprises a housing (2) wherein a drive mechanism comprising a drive member (3) is at least partially enclosed and a dosing element (34) which is fixed relative to the drive member (3). Here, a dose can be set by rotating the dosing element (34) relative to the housing (2) in a dose set direction (105) and the dose can be dispensed by pushing the dosing element (34) towards the housing (2). Moreover, a method is provided for operating an injection device (1) for the administration of a fixed dose of a medication: A dose can be set by rotating a dosing element (34), a dose can be dispensed by pushing the dosing element (34) towards the housing (2) and a dose can be cancelled by rotating the dosing element (34) in a direction (106) opposite to the dose set direction (105).

    摘要翻译： 提供了一种用于施用固定剂量的药物的注射装置（1）。 注射装置（1）包括壳体（2），其中包括驱动构件（3）的驱动机构至少部分地封闭，并且相对于驱动构件（3）固定的计量元件（34）。 这里，可以通过以剂量设定方向（105）相对于壳体（2）旋转计量元件（34）来设定剂量，并且可以通过将剂量元件（34）推向壳体（2）来分配剂量， 。 此外，提供了一种用于操作用于施用固定剂量的药物的注射装置（1）的方法：剂量可以通过旋转剂量元件（34）来设定，剂量可以通过推动剂量元件（ 34）朝向壳体（2），并且可以通过在与剂量设定方向（105）相反的方向（106）旋转定量元件（34）来消除剂量。

    Assembly for a Drug Delivery Device
    24.
    发明申请
    Assembly for a Drug Delivery Device 有权
    药物输送装置的装配

    公开(公告)号：US20120283653A1

    公开(公告)日：2012-11-08

    申请号：US13395701

    申请日：2010-09-29

    申请人： Catherine Anne MacDonald ,  Robert Veasey ,  Christopher Jones ,  Garen Kouyoumjian

    发明人： Catherine Anne MacDonald ,  Robert Veasey ,  Christopher Jones ,  Garen Kouyoumjian

    IPC分类号： A61M5/315

    CPC分类号： A61M5/24 ,  A61M5/3146 ,  A61M5/31543 ,  A61M5/31555 ,  A61M5/31556 ,  A61M5/3156 ,  A61M5/3158 ,  A61M2005/2407 ,  A61M2005/2488 ,  A61M2005/2492

    摘要： A resettable drive mechanism for a drug delivery device (1) comprises a piston rod assembly (32) and an interaction member (23). The piston rod assembly (32) comprises a guide track (18) running along the piston rod assembly (32), the guide track (18) comprising at least one delivery section (18A) and at least one reset section (18B). The reset section (18B) is arranged to continue the delivery section (18A). The delivery section (18A) comprises at least one blocking means (19). The interaction member (23) is configured to cooperate with the guide track (18). For delivering a dose of a drug (24), the piston rod assembly (32) is axially displaceable in a dose delivery direction away from an axial starting position, the interaction member (23) cooperating with the delivery section (18A) and the blocking means (19) passing the interaction member (23) when the piston rod assembly (32) is displaced in the dose delivery direction. Axial displacement of the piston rod assembly (32) towards the axial starting position is prevented by mechanical interaction of the blocking means (19) and the interaction member (23) when the interaction member (23) cooperates with the delivery section (18A). For resetting the drug delivery device (1), the interaction member (23) is configured to cooperate with the reset section (18B), the piston rod assembly (32) being axially displaced towards the axial starting position, the blocking means (19) being offset from the interaction member (23) and passing the axial position of the interaction member (23) when the piston rod assembly (32) is axially displaced towards the axial starting position. Also, a piston rod assembly (32) is proposed.

    摘要翻译： 用于药物输送装置（1）的可重置驱动机构包括活塞杆组件（32）和相互作用构件（23）。 活塞杆组件（32）包括沿着活塞杆组件（32）延伸的导轨（18），导轨（18）包括至少一个输送部分（18A）和至少一个复位部分（18B）。 复位部分（18B）布置成继续传送部分（18A）。 输送部分（18A）包括至少一个阻挡装置（19）。 相互作用构件（23）构造成与导轨（18）配合。 为了递送药物（24）的剂量，活塞杆组件（32）可以在远离轴向起始位置的剂量递送方向上轴向移位，相互作用构件（23）与输送段（18A）配合并阻塞 当活塞杆组件（32）在剂量递送方向上移位时，装置（19）使相互作用构件（23）通过。 当相互作用构件（23）与输送段（18A）配合时，通过阻挡装置（19）和相互作用构件（23）的机械相互作用来防止活塞杆组件（32）朝向轴向起始位置的轴向位移。 为了复位药物输送装置（1），相互作用构件（23）构造成与复位部分（18B）配合，活塞杆组件（32）朝着轴向起始位置轴向移位，阻挡装置（19） 当所述活塞杆组件（32）朝向所述轴向起始位置轴向移位时，所述相互作用构件（23）偏离所述相互作用构件（23）的轴向位置。 此外，提出了一种活塞杆组件（32）。

    Drive mechanism for a drug delivery device
    27.
    发明授权
    Drive mechanism for a drug delivery device 有权
    药物输送装置的驱动机构

    公开(公告)号：US09375535B2

    公开(公告)日：2016-06-28

    申请号：US13497378

    申请日：2010-09-29

    申请人： Robert Veasey ,  Simon Lewis Bilton ,  Christopher Jones ,  Garen Kouyoumjian ,  Catherine Anne Macdonald

    发明人： Robert Veasey ,  Simon Lewis Bilton ,  Christopher Jones ,  Garen Kouyoumjian ,  Catherine Anne Macdonald

    IPC分类号： A61M5/00 ,  A61M5/315 ,  A61M5/24 ,  A61M5/31

    CPC分类号： A61M5/3158 ,  A61M5/24 ,  A61M5/31541 ,  A61M5/31543 ,  A61M5/31555 ,  A61M5/31556 ,  A61M2005/2407 ,  A61M2005/2477 ,  A61M2005/3126

    摘要： According to one aspect, a resettable drive assembly for a drug delivery device is provided for. The resettable drive assembly may comprise a housing having a proximal end and a distal end, a piston rod being rotatable with respect to the housing and being axially displaceable with respect to the housing between a proximal start position and a distal end position, a drive member for distally displacing the piston rod towards the end position when dispensing a dose, and a stop member. The drive assembly may be configured such that the drive member is operable to interact with the piston rod for forming an unlockable first interlock, the first interlock being operable to block proximal movement of the piston rod with respect to the drive member. The drive assembly may be configured such that the stop member is operable to interact with the piston rod for forming an unlockable second interlock, the second interlock being operable to block proximal movement of the piston rod with respect to the housing. The drive assembly may be configured such that, when the drive assembly is in a drive mode, the first and second interlocks are locked such that proximal movement of the piston rod from the end position to the start position is prevented by the first interlock and the second interlock. The drive assembly may be configured such that, for switching the drive assembly from the drive mode to a reset mode, the piston rod is rotatable with respect to the drive member for unlocking the first interlock and the stop member and the piston rod are rotatable with respect to each other for unlocking the second interlock. The drive assembly may be configured such that, when the drive assembly is in the reset mode, the first interlock and the second interlock are unlocked such that proximal movement of the piston rod to the start position is allowed. Further, a drug delivery device and a use of a spring are provided for.

    摘要翻译： 根据一个方面，提供了一种用于药物递送装置的可重置驱动组件。 可重置驱动组件可以包括具有近端和远端的壳体，活塞杆可相对于壳体旋转并且能够在近端起始位置和远端位置之间相对于壳体轴向移动，驱动构件 用于在分配剂量时将活塞杆朝向终端位置移动，以及止挡构件。 驱动组件可以构造成使得驱动构件可操作以与活塞杆相互作用以形成可解锁的第一互锁，第一互锁可操作以阻止活塞杆相对于驱动构件的近端运动。 驱动组件可以被配置为使得止动构件可操作以与活塞杆相互作用以形成可解锁的第二互锁，所述第二互锁可操作以阻止活塞杆相对于壳体的近端运动。 驱动组件可以构造成使得当驱动组件处于驱动模式时，第一和第二互锁被锁定，使得活塞杆从终端位置到起始位置的近端运动通过第一互锁来防止，并且 第二个互锁。 驱动组件可以被配置成使得为了将驱动组件从驱动模式切换到复位模式，活塞杆可相对于驱动构件旋转，用于解锁第一联锁装置，止动构件和活塞杆可随着 彼此相对以解锁第二互锁。 驱动组件可以被构造成使得当驱动组件处于复位模式时，第一互锁和第二联锁被解锁，使得允许活塞杆的近端运动到起始位置。 此外，提供了药物递送装置和弹簧的使用。

    Method for Assembling a Drug Delivery Device, Assembly for a Drug Delivery Device and Piston Rod for a Drug Delivery Device
    30.
    发明申请
    Method for Assembling a Drug Delivery Device, Assembly for a Drug Delivery Device and Piston Rod for a Drug Delivery Device 审中-公开
    用于组装药物递送装置的装置，用于药物递送装置的组装和用于药物递送装置的活塞杆

    公开(公告)号：US20120283662A1

    公开(公告)日：2012-11-08

    申请号：US13496701

    申请日：2010-09-29

    申请人： Catherine Anne MacDonald ,  Robert Veasey ,  David Plumptre ,  Christopher Jones ,  Garen Kouyoumjian

    发明人： Catherine Anne MacDonald ,  Robert Veasey ,  David Plumptre ,  Christopher Jones ,  Garen Kouyoumjian

    IPC分类号： A61M5/315 ,  B29C57/06

    CPC分类号： A61M5/24 ,  A61M5/3146 ,  A61M5/31511 ,  A61M5/31515 ,  A61M5/31555 ,  A61M5/31585 ,  A61M2005/2407 ,  A61M2005/3121 ,  A61M2207/00

    摘要： A method for assembling a drug delivery device comprising a body (2) retaining a piston rod (3) and a cartridge (5) retaining a bung (6) and holding a drug, said body (2) having a distal end (11) and a proximal end (12),comprises the following steps: A) Providing the cartridge (5) and the body (2) retaining the piston rod (3), wherein the piston rod (3) is plastically deformable, at least a part of said plastically deformable piston rod being manufactured from a plastically deformable material, B) Applying a force on the piston rod (3), at least a part of the piston rod (3) being in a state that allows plastic deformation, so that the piston rod (3) is plastically deformed and an element of the piston rod (3) abuts the bung (6), C) Applying conditions in order to bring the plastically deformed piston rod (3) of step B) into an altered state wherein no further plastic deformation takes place, D) Securing the cartridge (5) to the body (2).

    摘要翻译： 一种用于组装药物递送装置的方法，包括保持活塞杆（3）的主体（2）和保持栓（6）并保持药物的药筒（5），所述主体（2）具有远端（11） 和近端（12），包括以下步骤：A）提供保持活塞杆（3）的筒（5）和主体（2），其中活塞杆（3）是塑性可变形的，至少一部分 所述塑性变形的活塞杆由塑性变形的材料制成，B）在活塞杆（3）上施加力，活塞杆（3）的至少一部分处于允许塑性变形的状态，使得 活塞杆（3）塑性变形，并且活塞杆（3）的一个元件邻接钢栓（6），C）为了使步骤B）的塑性变形的活塞杆（3）进入改变状态，施加条件，其中 不会发生进一步的塑性变形，D）将盒（5）固定到主体（2）上。