-
21.发明申请公开(公告)号：US20090264508A1
公开(公告)日：2009-10-22
申请号：US11992125
申请日：2006-09-15
申请人： Bruce A. Sullenger , Juliana M. Layzer , Christopher P. Rusconi , Sabah Oney , Nanette L.S. Que-Gewirth
发明人： Bruce A. Sullenger , Juliana M. Layzer , Christopher P. Rusconi , Sabah Oney , Nanette L.S. Que-Gewirth
IPC分类号： A61K31/7088 , C40B50/06 , C07H21/02 , A61P35/00
CPC分类号： C12N15/1048 , C07K14/745 , C12N15/111 , C12N15/115 , C12N2310/16 , C12N2320/13
摘要： Focused aptamer libraries are constructed in accordance with a proteome (i.e., complex mixture of native biomolecules). The libraries may be screened to identify one or more candidate aptamers with desired biological activities other than specific binding to a target. Aptamers which are selected or derivatives thereof may be used for those specific activities in biological systems. Any combination of deconvoluting a focused library (functional profiling), increasing frequencies of particular aptamers in a focused library (Laser SELEX), and decreasing frequencies of particular aptamers in a focused library (DeSELEX) may be performed prior to assaying biological activity.
摘要翻译： 根据蛋白质组（即天然生物分子的复杂混合物）构建聚焦的适体文库。 可以筛选文库以鉴定具有除特异性结合靶标以外的所需生物活性的一种或多种候选适体。 选择的适体或其衍生物可用于生物系统中的那些特定活性。 在分析生物活性之前，可以进行解卷积聚焦库（功能分析），聚焦库（Laser SELEX）中特定适体的频率增加以及聚焦文库（DeSELEX）中特定适体的频率降低的任何组合。
-
公开(公告)号：US20090163437A1
公开(公告)日：2009-06-25
申请号：US12252994
申请日：2008-10-16
IPC分类号： A61K31/7088
CPC分类号： C12N15/115 , C12N2310/113 , C12N2310/16 , C12N2310/351 , C12N2320/31 , C12N2320/32 , C12N2320/35
摘要： An improved method of administration of an aptamer and modulator system to regulate blood coagulation in a host is provided wherein the aptamer is administered subcutaneously and the modulator is administered either subcutaneously or intravenously. This method for sustained aptamer activity using intermittent subcutaneous injections further allows for titrated modulation of the aptamer activity by administration of the modulator.
摘要翻译： 提供改进的适配体和调节剂系统的调节方法以调节宿主中的血液凝固，其中适体被皮下施用，调节剂以皮下或静脉内施用。 使用间歇皮下注射的持续适体活性的这种方法还允许通过施用调节剂滴定调节适体活性。
-
公开(公告)号：US07531524B2
公开(公告)日：2009-05-12
申请号：US11546190
申请日：2006-10-11
CPC分类号： C12N15/115 , A61K31/711 , A61K47/60 , A61K48/00 , C07H21/02 , C08G65/329 , C08L2203/02 , C12N2310/16 , C12N2310/321 , C12N2310/322 , C12N2310/351 , C12N2310/531 , C12N2310/3521
摘要： The invention provides improved nucleic acid ligands with enhanced stability that inhibit coagulation and improved modulators of the nucleic acids to provide ideal modulators of coagulation. These improved nucleic acids and modulators are particularly useful for inhibiting coagulation in a host undergoing a therapeutic regime such as surgery or coronary artery bypass.
摘要翻译： 本发明提供改进的核酸配体，其具有增强的稳定性，其抑制凝血和改进的核酸调节剂以提供理想的凝血调节剂。 这些改进的核酸和调节剂特别可用于抑制经历诸如手术或冠状动脉旁路治疗方案的宿主中的凝血。
-
公开(公告)号：US20080221053A1
公开(公告)日：2008-09-11
申请号：US11925645
申请日：2007-10-26
CPC分类号： C12N15/1048 , A61K38/00 , C07H21/02 , C12N15/115 , C12N2310/322 , C12Y304/21005 , C12Y304/21006 , C12Y304/21021 , C12Y304/21022
摘要： RNA aptamers and methods for identifying the same are disclosed. The RNA aptamers selectively bind coagulation factors, E2F family members, Ang1 or Ang2, and therapeutic and other uses for the RNA aptamers are also disclosed.
-
公开(公告)号：US20080125383A1
公开(公告)日：2008-05-29
申请号：US11546190
申请日：2006-10-11
IPC分类号： A61K31/711 , A01N1/02 , A61P7/02 , C07H21/02
CPC分类号： C12N15/115 , A61K31/711 , A61K47/60 , A61K48/00 , C07H21/02 , C08G65/329 , C08L2203/02 , C12N2310/16 , C12N2310/321 , C12N2310/322 , C12N2310/351 , C12N2310/531 , C12N2310/3521
摘要： The invention provides improved nucleic acid ligands with enhanced stability that inhibit coagulation and improved modulators of the nucleic acids to provide ideal modulators of coagulation. These improved nucleic acids and modulators are particularly useful for inhibiting coagulation in a host undergoing a therapeutic regime such as surgery or coronary artery bypass.
摘要翻译： 本发明提供改进的核酸配体，其具有增强的稳定性，其抑制凝血和改进的核酸调节剂以提供理想的凝血调节剂。 这些改进的核酸和调节剂特别可用于抑制经历诸如手术或冠状动脉旁路治疗方案的宿主中的凝血。
-
-
-
-
搜索结果
25 条记录 (耗时 0.032 秒)
