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21.发明授权Method of making a cochlear electrode array with electrode contacts on medial side 有权制造具有内侧电极触点的耳蜗电极阵列的方法
公开(公告)号：US6144883A
公开(公告)日：2000-11-07
申请号：US346879
申请日：1999-07-02
申请人： Janusz A. Kuzma
发明人： Janusz A. Kuzma
IPC分类号： A61N1/05
CPC分类号： A61N1/0541 , Y10T29/49117 , Y10T29/49179
摘要： A method of making an implantable electrode array, adapted for insertion into a cochlea, provides stability relative to the electrode contact direction. In-line electrodes are spaced-apart along one side of a flexible carrier. The structure of the electrode array facilitates bending of the array with the electrode contacts on the inside of the bend, yet deters flexing or twisting of the array in other directions. The electrode contacts preferably are each made from two strips of metal, arranged in a "T" shape (top view). During assembly, all of the "T" strips are held in position on an iron sheet. Two wire bundles are formed that pass along each side of each "T". The leg of each "T" is folded over to pinch at least one of the wires from one of the wire bundles therebetween. This pinched wire is then resistance welded to the strip. The sides of the "T" are then folded up and touch or nearly touch to form a ".DELTA." shape (side view). The wire bundles going to more distal electrodes pass through the ".DELTA." and are thus engaged by the ".DELTA.". A flexible carrier, made from, e.g., silicone rubber, is molded over and around the wire bundles and folded electrode T's, preferably in a slightly curved shape, The iron sheet is chemically etched away, leaving an array of spaced-apart electrode contact areas along one edge of the flexible carrier, each of which is electrically attached to at least one wire which passes through the carrier. The electrode array may be manufactured using low cost technology.
摘要翻译： 制造适于插入耳蜗的可植入电极阵列的方法提供了相对于电极接触方向的稳定性。 在线电极沿着柔性载体的一侧间隔开。 电极阵列的结构有利于电极触点在弯曲部内侧的阵列的弯曲，而且阻止阵列在其它方向的弯曲或扭转。 电极接触件优选地由两条以“T”形（顶视图）排列的金属条制成。 在组装期间，所有的“T”条都保持在铁板上的适当位置。 形成通过每个“T”的每一侧的两个线束。 每个“T”的腿被折叠以从其间的线束之一夹紧至少一根电线。 然后将该夹紧的线材电阻焊接到带材上。 然后将“T”的侧面折叠起来，触摸或接触以形成“DELTA”形状（侧视图）。 穿过更远端电极的电线束通过“DELTA”并因此被“DELTA”接合。 由例如硅橡胶制成的柔性载体在电线束和折叠电极T之上和之上被模制，优选地以稍微弯曲的形状。铁片被化学蚀刻掉，留下一排间隔开的电极接触面积 沿柔性载体的一个边缘，每个边缘电连接到穿过载体的至少一根线。 电极阵列可以使用低成本技术制造。
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公开(公告)号：US6119044A
公开(公告)日：2000-09-12
申请号：US259199
申请日：1999-03-01
申请人： Janusz A. Kuzma
发明人： Janusz A. Kuzma
IPC分类号： A61N1/05
CPC分类号： A61N1/0541
摘要： An implantable electrode array, adapted for insertion into either a left or right cochlea, assumes a spiral shape so as to hug the modiolar wall of the cochlea after insertion into the cochlea. All of the electrode contacts are spaced apart along one edge or side of the array, termed the "medial side", which medial side resides on the inside of the spiral. The electrode contacts are thus positioned in close proximity to the modiolar wall, closest to the ganglion cells that are to be stimulated by the electrode array. A positioning stylet made from a suitable memory wire is inserted into a longitudinal channel of the array. The stylet is made from memory wire and has properties selected to return to a desired memory spiral shape at or near body temperature (e.g., approximately 37.degree. C. or 98.6.degree. F.). The positioning stylet is cooled and bent as needed to assume a relatively straight, or non-spiral shape. While relatively straight, the stylet is slidably inserted into the longitudinal channel of the electrode array. The electrode array is then inserted into the cochlea in conventional manner. As the stylet within the electrode array warms to body temperature, it returns to its spiral memory shape, thereby causing the electrode array to also assume a spiral shape, thus positioning the electrode contacts of the electrode array against the modiolar wall.
摘要翻译： 适于插入左耳或右耳蜗的可植入电极阵列呈螺旋状，以便在插入耳蜗后拥抱耳蜗的模腔壁。 所有电极触点沿着阵列的一个边缘或侧面间隔开，称为“内侧”，内侧位于螺旋内侧。 因此，电极接触件位于紧邻由待电极阵列刺激的神经节细胞的模壁上。 由合适的存储线制成的定位探针插入到阵列的纵向通道中。 探针由记忆线制成，并且具有选定的属性以在体温或接近体温（例如，约37℃或98.6°F）下返回到期望的记忆螺旋形状。 定位探针被冷却并根据需要弯曲以呈现相对直的或非螺旋形的形状。 虽然相对直的，探针可滑动地插入电极阵列的纵向通道。 然后以常规方式将电极阵列插入耳蜗。 当电极阵列内的探针温度达到体温时，其回到其螺旋形记忆形状，从而使电极阵列也呈现螺旋形状，从而将电极阵列的电极接触件抵靠模块壁。
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公开(公告)号：US6070105A
公开(公告)日：2000-05-30
申请号：US140033
申请日：1998-08-26
申请人： Janusz A. Kuzma
发明人： Janusz A. Kuzma
CPC分类号： A61N1/0541
摘要： An electrode array has a flexible carrier that, when viewed in cross-section, is much more flexible in a first direction than in a second direction orthogonal thereto. The flexible direction is the direction that allows the array to readily flex so as to assume the general spiral or circular shape of the scala tympani duct within the cochlea. The less-flexible direction is the direction that makes it difficult for the array to twist as it is inserted within the scala tympani duct. By placing the electrode contacts of the array on or near that surface of the array which becomes the inner surface of the spiral shape once implantation has occurred, the electrode array may be inserted within the cochlea using minimal force, yet twisting of the array becomes unlikely during insertion or thereafter. Four separate embodiments of the electrode array are described.
摘要翻译： 电极阵列具有柔性载体，当从横截面观察时，其在与第一方向相比在第一方向上比在与其正交的第二方向上更灵活。 灵活的方向是允许阵列容易弯曲以便呈现耳蜗内鼓膜鼓风管的一般螺旋或圆形形状的方向。 较不灵活的方向是使阵列难以在插入鼓鼓管内扭转的方向。 通过将阵列的电极接触放置在阵列的表面上或附近，其一旦植入就成为螺旋形状的内表面，则可以使用最小的力将电极阵列插入到耳蜗内，而阵列的扭转变得不可能 在插入期间或之后。 描述电极阵列的四个独立实施例。
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公开(公告)号：US4522209A
公开(公告)日：1985-06-11
申请号：US483862
申请日：1983-04-11
CPC分类号： A61F2/0095 , A61N1/37 , A61N2001/37294
摘要： A test system for a sealed, sterile package containing a cochlear prosthesis electrode. A light-emitting diode has its two leads in contact with at least two different conducting bands on the electrode. The prosthesis, which is externally-powered, is operated so as to supply a stimulus current between the two bands. If the light-emitting diode is illuminated, proper operation of the prosthesis can be verified without unsealing the package.
摘要翻译： 一种用于密封的无菌包装的测试系统，其包含耳蜗假体电极。 发光二极管的两个引线与电极上的至少两个不同的导电带接触。 外部供电的假体被操作以便在两个带之间提供刺激电流。 如果发光二极管被照亮，则可以在不打开封装的情况下验证假体的适当操作。
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公开(公告)号：US08646172B2
公开(公告)日：2014-02-11
申请号：US13013599
申请日：2011-01-25
申请人： Janusz A. Kuzma , Anne M. Pianca
发明人： Janusz A. Kuzma , Anne M. Pianca
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/0553 , Y10T29/49117 , Y10T29/49204 , Y10T29/49208 , Y10T29/4922
摘要： A method of manufacturing a stimulation lead includes providing a lead body having an insulation section that defines a central lumen extending along the insulation section and conductor lumens extending along the insulation section and arranged around, and external to, the central lumen. The lead body also includes conductive contacts located along an axial end of the lead body and conductor wires with each conductor wire disposed within one of the conductor lumens and each of the conductor lumens having at least one of the conductor wires disposed therein. After providing the lead body, conductively at least one of the conductor wires to each of the conductive contacts; and placing non-conductive material into a portion of at least one of the conductor lumens of the lead body. A portion of the conductor lumens and at least a portion of the non-conductive material are disposed radially beneath the conductive contacts.
摘要翻译： 制造刺激引线的方法包括提供引线本体，该引线本体具有绝缘部分，该绝缘部分限定沿着绝缘部分延伸的中心管腔和沿着绝缘部分延伸并且布置在中心管腔周围和外部的导体管腔。 引线体还包括位于引线主体的轴向端部的导电触点和导体布线，导体布线设置在导体腔内的一个内，并且每个导体流明具有布置在其中的至少一个导线。 在提供引线体之后，导电地将至少一根导线连接到每个导电触头; 以及将非导电材料放置在所述引线体的导体腔中的至少一个的一部分中。 导体内腔的一部分和非导电材料的至少一部分径向设置在导电触头下方。
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公开(公告)号：US08311649B2
公开(公告)日：2012-11-13
申请号：US11138146
申请日：2005-05-26
IPC分类号： A61N1/04
CPC分类号： A61N1/0541
摘要： An electrode array design is provided which is intended for deep insertion into a human cochlea. The distal most portion of the lead can be very thin and flexible and have a wider arc than the remainder of the curved electrode array portion of the lead, which has a more aggressive arc. As a result, the distal most portion of the electrode array can be laterally positioned in a selected cochlear duct, whereas, concurrently, the remaining, more proximal part of the electrode array may be positioned medially (perimodiolar) within the cochlear duct.
摘要翻译： 提供了用于深入人耳蜗的电极阵列设计。 引线的最远端部分可以是非常薄且柔性的并且具有比引线更弯曲的弧形电极阵列部分的其余部分更宽的弧。 结果，电极阵列的最远端部分可以横向地定位在所选择的耳蜗导管中，而同时，电极阵列的剩余的更近端的部分可以在耳蜗导管内侧定位（旁二极管）。
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27.发明授权Electrode arrangement for nerve stimulation and methods of treating disorders 有权用于神经刺激的电极装置和治疗疾病的方法公开(公告)号：US07610103B2
公开(公告)日：2009-10-27
申请号：US11311502
申请日：2005-12-19
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61N1/0556
摘要： A stimulator arrangement for stimulating nerves or other tissue includes an electrode arrangement having a substrate and a plurality of electrodes disposed on the substrate. The substrate is configured and arranged to be in a curved state prior to implantation into the body and to flatten with exposure to the body after implantation. The stimulator arrangement may also include a stimulator unit coupled to the electrode arrangement. The stimulator unit may also be implantable.
摘要翻译： 用于刺激神经或其他组织的刺激器装置包括具有基底和设置在基底上的多个电极的电极装置。 衬底被配置和布置成在植入体内之前处于弯曲状态，并且在植入后暴露于身体时变平。 刺激器装置还可以包括耦合到电极装置的刺激器单元。 刺激器单元也可以是可植入的。
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28.发明授权公开(公告)号：US07050858B1
公开(公告)日：2006-05-23
申请号：US10116464
申请日：2002-04-03
IPC分类号： A61N1/00
CPC分类号： A61N1/0541 , A61B17/3403 , A61B17/3468 , A61B2017/00787
摘要： An insertion tool uses a stylet wire to help guide an electrode system into a cochlea. The insertion tool includes three main elements or parts: a handle, a guide and a slider. The handle is made from light stainless steel tube flattened in front with a machined slot. The guide consists of a plurality of metal tubes, fixed to each other within a holding bracket. In one embodiment, the slider includes a stabilizer wire, a long stylet wire, and a short stylet wire. During the assembly process, the stabilizer and stylet wires are inserted into respective tubes of the guide and the end of the stabilizer wire is bent to form an offset. The electrode system is loaded onto the tool by inserting the short stylet wire into a holder that supports the electrode lead.
摘要翻译： 插入工具使用探针线来帮助引导电极系统进入耳蜗。 插入工具包括三个主要元件或部件：手柄，引导件和滑块。 手柄由轻质不锈钢管制成，前面带有加工槽。 引导件由多个金属管组成，其在固定支架内相互固定。 在一个实施例中，滑块包括稳定线，长针刺线和短探针线。 在组装过程中，将稳定器和探针线插入到引导件的相应管中，并且稳定线的端部弯曲以形成偏移。 通过将短的针刺线插入支撑电极引线的支架中，将电极系统装载到工具上。
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29.发明授权Fully implantable microstimulator for spinal cord stimulation as a therapy for chronic pain 有权用于脊髓刺激的完全可植入的微刺激作为慢性疼痛的治疗公开(公告)号：US06871099B1
公开(公告)日：2005-03-22
申请号：US09929597
申请日：2001-08-13
CPC分类号： A61N1/36071
摘要： An implantable stimulator(s), small enough to be located near or within an area of the spine responsible for sensations in a region experiencing chronic pain uses a power source/storage device, such as a rechargeable battery. Periodic recharging of such a power source/storage device is accomplished, for example, by inductive coupling with an external appliance. The small stimulator provides a means of stimulating a nerve(s) or other tissue when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the stimulator(s) and for the transmission of power, it necessary. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one implant includes at least one sensor, and the sensed condition is used to adjust stimulation parameters.
摘要翻译： 小到足以位于脊柱区域内的负责在慢性疼痛区域感觉的植入式刺激器使用诸如可再充电电池的电源/存储装置。 这样的电源/存储装置的定期再充电例如通过与外部电器的感应耦合来实现。 小刺激器提供了在需要时刺激神经或其他组织的手段，而不需要在刺激期间的外部器具。 必要时，必须使用外部设备将数据传送到和/或从激励器传输，并传输电力。 在优选实施例中，系统能够进行开环和闭环操作。 在闭环操作中，至少一个植入物包括至少一个传感器，并且所感测到的条件用于调整刺激参数。
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公开(公告)号：US06733485B1
公开(公告)日：2004-05-11
申请号：US10133770
申请日：2002-04-26
IPC分类号： A61M3100
CPC分类号： A61M31/002 , A61M5/14276 , A61M2205/3523 , A61N1/205 , A61N1/326
摘要： A small implantable stimulator(s) includes at least two electrodes for delivering electrical stimulation to surrounding tissue and/or a pump and at least one outlet for delivering a drug or drugs to surrounding tissue. One electrochemotherapy method disclosed includes delivery of electrical stimulation in the form of a direct electric current and/or a periodic waveform that locally potentiates the cytotoxic effects of a systemically and/or locally administered chemotherapy agent(s). Open- and closed-loop systems are disclosed.
摘要翻译： 小型可植入刺激器包括至少两个用于将电刺激递送至周围组织和/或泵的电极以及用于将药物或药物递送至周围组织的至少一个出口。 所公开的一种电化疗方法包括以局部增强全身和/或局部施用的化疗剂的细胞毒性作用的直接电流和/或周期性波形的形式递送电刺激。 公开了开环和闭环系统。
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