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21.发明授权Label-free optical sensing and characterization of biomolecules by d8 or d10 metal complexes 有权d8或d10金属络合物的无标记光学感测和生物分子表征公开(公告)号：US08309304B2
公开(公告)日：2012-11-13
申请号：US12017108
申请日：2008-01-21
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： C07D401/14 , C07D239/47 , C07D487/04 , C07F15/0086 , G01N33/52
摘要： The present invention provides a composition for detecting and/or characterizing a multiple-charged biomolecule comprising a charged d8 or d10 metal complex, wherein the metal complex electrostatically binds to the multiple-charged biomolecule to induce aggregation and self-assembly of the metal complex through metal-metal interactions, π . . . π interactions, or a combination of both interactions. The present invention further provides assay methods and kits for label-free optical detection and/or characterization of biomolecules carrying multiple charges, e.g., single-stranded nucleic acids, using a composition comprising a charged d8 or d10 metal complex.
摘要翻译： 本发明提供用于检测和/或表征包含带电d8或d10金属络合物的多电荷生物分子的组合物，其中所述金属络合物与多电荷生物分子静电结合以诱导金属络合物的聚集和自组装通过 金属 - 金属相互作用 。 。 。 ＆pgr 互动，或两者互动的组合。 本发明还提供了使用包含带电荷的d8或d10金属络合物的组合物进行无标记光学检测和/或表征携带多个电荷的多重电荷（例如单链核酸）的测定方法和试剂盒。
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公开(公告)号：US20120143875A1
公开(公告)日：2012-06-07
申请号：US12958151
申请日：2010-12-01
申请人： Anish Das Sarma , Alpa Jain , Cong Yu
发明人： Anish Das Sarma , Alpa Jain , Cong Yu
IPC分类号： G06F17/30
CPC分类号： G06F16/3346 , G06F16/288
摘要： Method, system, and programs for detecting dynamic relationship and discovering dynamic events. Data from a first data source is first received. At least one dynamic relation candidate is identified and each dynamic relation candidate involves multiple entities. The at least one dynamic relation candidate is identified based on temporal properties with respect to the entities exhibited in the data from the first data source. Dynamic relations are then extracted by corroborating the temporal properties of the entities involved in the at least one dynamic relation candidate with that of the same entities exhibited in data from a second data source. Then, a dynamic event that gives rise to the dynamic relations among different entities is detected.
摘要翻译： 用于检测动态关系和发现动态事件的方法，系统和程序。 首先接收来自第一数据源的数据。 识别至少一个动态关系候选，并且每个动态关系候选涉及多个实体。 基于在来自第一数据源的数据中显示的实体的时间属性来识别至少一个动态关系候选。 然后通过证实在至少一个动态关系候选中涉及的实体的时间属性与来自第二数据源的数据中展示的相同实体的时间属性来提取动态关系。 然后，检测到引起不同实体之间的动态关系的动态事件。
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公开(公告)号：US20100227301A1
公开(公告)日：2010-09-09
申请号：US12398126
申请日：2009-03-04
IPC分类号： G09B19/00
CPC分类号： G09B19/00
摘要： Disclosed are methods and apparatus for extracting information from one or more documents. A training and execution plan is received, and such plan specifies invocation of a trainer operator for initiating training of a trainee operator based on a set of training documents so as to generate a new trained operator that is to then be invoked so as to extract information from one or more unknown documents. The trainee operator is configured to extract information from one or more unknown documents, and each training document is associated with classified information. After receipt of the training and execution plan, the trainer operator is automatically executed to train the trainee operator based on the specified training documents so as to generate a new trained operator for extracting information from documents. The new trained operator is a new version of the trainee operator. After receipt of the training and execution plan, both the trainee operator are automatically retained for later use in extracting information from one or more unknown documents and the new trained operator for later use in extracting information from one or more unknown documents. After receipt of the training and execution plan, the new trained operator is automatically executed on one or more unknown documents so as to extract information from such one or more unknown documents.
摘要翻译： 公开了用于从一个或多个文档中提取信息的方法和装置。 接收到训练和执行计划，并且该计划规定了基于一组训练文件来引导训练者操作员启动对训练操作员的训练，以便产生一个新的经过训练的操作者，然后被调用以便提取信息 来自一个或多个未知文件。 受训操作员被配置为从一个或多个未知文档中提取信息，并且每个训练文档与分类信息相关联。 在收到培训和执行计划后，培训师操作员将根据指定的培训文件自动执行培训受训操作员，以便生成一个新的训练有素的操作员，从文档中提取信息。 新受过训练的操作员是受训操作员的新版本。 在接收到训练和执行计划之后，训练者操作员将被自动保留以便以后用于从一个或多个未知文件中提取信息，并且新训练的操作者用于随后用于从一个或多个未知文档中提取信息。 在接收到训练和执行计划之后，新的受过训练的操作者被自动执行一个或多个未知文件，以从这样的一个或多个未知文件中提取信息。
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公开(公告)号：US07596559B2
公开(公告)日：2009-09-29
申请号：US10975213
申请日：2004-10-28
申请人： Lucian Popa , Cong Yu
发明人： Lucian Popa , Cong Yu
CPC分类号： G06F17/30929 , G06F17/30914 , Y10S707/99937 , Y10S707/99945
摘要： A system and method for data integration by querying multiple extensible markup language (XML) source schemas through a common XML target schema, wherein the system comprises XML mapping connections between the XML source schemas and the XML target schema, wherein the XML mapping connections accommodate XML mappings, the XML source schemas comprise data, and the XML target schema comprise a set of constraints, which comprise data merging rules for integrating the data from multiple source schemas comprising overlapping information; a target query associated with the target schema; and a query rewriter adapted to reformulate the target query in terms of the source schemas based on the mappings, and to integrate the data based on the set of constraints. The query rewriter is adapted to rewrite the target query into a set of source queries comprising the source schemas. A processor evaluates a union of the set of source queries.
摘要翻译： 一种用于通过公共XML目标模式查询多个可扩展标记语言（XML）源模式的数据集成的系统和方法，其中该系统包括XML源模式与XML目标模式之间的XML映射连接，其中XML映射连接容纳XML XML源模式包括数据，并且XML目标模式包括一组约束，其包括用于对来自包括重叠信息的多个源模式的数据进行集成的数据合并规则; 与目标模式相关联的目标查询; 以及查询重写器，其适于根据所述映射对所述源模式重新格式化所述目标查询，以及基于所述约束集合来整合所述数据。 查询重写器适于将目标查询重写为包括源模式的一组源查询。 处理器评估源查询集合的并集。
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25.发明申请Label-Free Optical Sensing and Characterization of Biomolecules by D8 or D10 Metal Complexes 有权D8或D10金属络合物的无标记光学感应和生物分子表征公开(公告)号：US20070190549A1
公开(公告)日：2007-08-16
申请号：US11625109
申请日：2007-01-19
申请人： Vivian Yam , Cong Yu , Kenneth Chan , Keith Wong
发明人： Vivian Yam , Cong Yu , Kenneth Chan , Keith Wong
CPC分类号： C12Q1/68 , C07D239/47 , C07D401/14 , C07D487/04 , C07F15/0086 , G01N33/52 , C12Q2565/113 , C12Q2563/137
摘要： The present invention provides a composition for detecting and/or characterizing a multiple-charged biomolecule comprising a charged d8 or d10 metal complex, wherein the metal complex electrostatically binds to the multiple-charged biomolecule to induce aggregation and self-assembly of the metal complex through metal . . . metal interactions, π . . . π interactions, or a combination of both interactions. The present invention further provides assay methods and kits for label-free optical detection and/or characterization of biomolecules carrying multiple charges, e.g., single-stranded nucleic acids, polyaspartate, polyglutamate, using a composition comprising a charged d8 or d10 metal complex.
摘要翻译： 本发明提供了一种用于检测和/或表征包含带电d 8或d 10金属络合物的多电荷生物分子的组合物，其中金属络合物静电结合到 多电荷生物分子通过金属诱导金属络合物的聚集和自组装。 。 。 金属相互作用 。 。 pi相互作用或两种相互作用的组合。 本发明进一步提供了用于无携带光学检测和/或表征携带多种电荷的生物分子的测定方法和试剂盒，例如单链核酸，聚天冬氨酸，聚谷氨酸，使用包含带电荷的d SUP>或d 10金属络合物。
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公开(公告)号：US08412652B2
公开(公告)日：2013-04-02
申请号：US12398126
申请日：2009-03-04
IPC分类号： G06F15/18
CPC分类号： G09B19/00
摘要： After receipt of a training and execution plan, a trainer operator is automatically trained based on specified training documents so as to generate a new trained operator for extracting information from documents. The new trained operator is a new version of the trainee operator. Both trainee operators are automatically retained for later use in extracting information from one or more unknown documents. After receipt of the training and execution plan, the new trained operator is automatically executed on one or more unknown documents so as to extract information from such one or more unknown documents.
摘要翻译： 在接收到训练和执行计划之后，训练员操作员将根据指定的培训文件自动进行培训，以便生成一个新的训练有素的操作员，从文档中提取信息。 新受过训练的操作员是受训操作员的新版本。 两名学员操作员都会自动保留以供以后使用，从一个或多个未知文件中提取信息。 在接收到训练和执行计划之后，新的受过训练的操作者被自动执行一个或多个未知文件，以从这样的一个或多个未知文件中提取信息。
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28.发明授权Label-free optical sensing and characterization of biomolecules by d8 or d10 metal complexes 有权d8或d10金属络合物的无标记光学感测和生物分子表征公开(公告)号：US08057989B2
公开(公告)日：2011-11-15
申请号：US11625109
申请日：2007-01-19
CPC分类号： C12Q1/68 , C07D239/47 , C07D401/14 , C07D487/04 , C07F15/0086 , G01N33/52 , C12Q2565/113 , C12Q2563/137
摘要： The present invention provides a composition for detecting and/or characterizing a multiple-charged biomolecule comprising a charged d8 or d10 metal complex, wherein the metal complex electrostatically binds to the multiple-charged biomolecule to induce aggregation and self-assembly of the metal complex through metal . . . metal interactions, π . . . π interactions, or a combination of both interactions. The present invention further provides assay methods and kits for label-free optical detection and/or characterization of biomolecules carrying multiple charges, e.g., single-stranded nucleic acids, polyaspartate, polyglutamate, using a composition comprising a charged d8 or d10 metal complex.
摘要翻译： 本发明提供用于检测和/或表征包含带电d8或d10金属络合物的多电荷生物分子的组合物，其中所述金属络合物与多电荷生物分子静电结合以诱导金属络合物的聚集和自组装通过 金属。 。 。 金属相互作用 。 。 。 ＆pgr 互动，或两者互动的组合。 本发明还提供了使用包含带电d8或d10金属络合物的组合物的无标记光学检测和/或表征携带多个电荷的生物分子的测定方法和试剂盒，例如单链核酸，聚天冬氨酸，聚谷氨酸。
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29.发明申请SYSTEM AND METHOD FOR PROVIDING A GRAPHICAL USER INTERFACE FOR PREDICTION MARKETS 审中-公开用于提供用于预测市场的图形用户界面的系统和方法公开(公告)号：US20100058249A1
公开(公告)日：2010-03-04
申请号：US12201526
申请日：2008-08-29
申请人： Prasenjit Sarkar , Sharad Goel , David M. Pennock , Daniel Reeves , Yiling Chen , Cong Yu
发明人： Prasenjit Sarkar , Sharad Goel , David M. Pennock , Daniel Reeves , Yiling Chen , Cong Yu
IPC分类号： G06F3/048
摘要： A system for providing a probability output and receiving an input includes a processor and a memory unit in communication with the processor. The memory has processor-executable instructions that configure the processor to provide a user interface having the probability output, wherein the probability output is in a graphical form and receives an input from the user via the user interface, wherein the user provides the input by marking portions of the graphical form of the probability output.
摘要翻译： 用于提供概率输出和接收输入的系统包括与处理器通信的处理器和存储器单元。 存储器具有处理器可执行指令，其配置处理器以提供具有概率输出的用户界面，其中概率输出是图形形式并且经由用户界面从用户接收输入，其中用户通过标记来提供输入 部分图形的概率输出。
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30.发明申请Label-Free Optical Sensing and Characterization of Biomolecules by D8 or D10 Metal Complexes 有权D8或D10金属络合物的无标记光学感应和生物分子表征公开(公告)号：US20080153103A1
公开(公告)日：2008-06-26
申请号：US12017108
申请日：2008-01-21
IPC分类号： C12Q1/68
CPC分类号： C07D401/14 , C07D239/47 , C07D487/04 , C07F15/0086 , G01N33/52
摘要： The present invention provides a composition for detecting and/or characterizing a multiple-charged biomolecule comprising a charged d8 or d10 metal complex, wherein the metal complex electrostatically binds to the multiple-charged biomolecule to induce aggregation and self-assembly of the metal complex through metal-metal interactions, π . . . π interactions, or a combination of both interactions. The present invention further provides assay methods and kits for label-free optical detection and/or characterization of biomolecules carrying multiple charges, e.g., single-stranded nucleic acids, using a composition comprising a charged d8 or d10 metal complex.
摘要翻译： 本发明提供了一种用于检测和/或表征包含带电d 8或d 10金属络合物的多电荷生物分子的组合物，其中金属络合物静电结合到 多电荷生物分子通过金属 - 金属相互作用诱导金属络合物的聚集和自组装。 。 。 pi相互作用或两种相互作用的组合。 本发明进一步提供了用于无携带光学检测和/或表征携带多种电荷的生物分子（例如单链核酸）的测定方法和试剂盒，其使用包含带电荷的d或d 金属络合物。
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