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294 条记录 (耗时 0.031 秒)

    Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists
    23.
    发明授权
    Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists 失效
    二取代的吗啉，氧氮杂或硫氮衍生物，其制备及其作为多巴胺d4受体拮抗剂的用途

    公开(公告)号：US06479491B1

    公开(公告)日：2002-11-12

    申请号：US09709297

    申请日：2000-11-13

    申请人： Oskar Axelsson ,  Dan Peters ,  Jorgen Scheel-Kruger ,  Elsebet Ostergaard Nielsen

    发明人： Oskar Axelsson ,  Dan Peters ,  Jorgen Scheel-Kruger ,  Elsebet Ostergaard Nielsen

    IPC分类号： A61K31535

    CPC分类号： C07D265/30 ,  C07D267/10 ,  C07D413/06

    摘要： The present invention relates to compounds of formula (I), any of it enantiomers, or any mixture thereof, or a pharmaceutically acceptable acid addition salt thereof, wherein R1, R2, R3, R4, R11, R12, R13, R14 and R15 each independently are hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, nitro, cyano, amino, acyl, alkylamino, dialkylamino, aminocarbonyl, or acylamino; R5 is hydrogen, alkyl, alkoxyalkyl, or phenylalkyl; X is —CH2—Z—, Z—CH2—, NH—CO—, —CO—NH—, or —CH═CH—; wherein Z is O, S, CH2, or NH; Y is O, —CH2—W—, —W—CH2—; wherein W is O, or S; and n is 0, 1 or 2. The compounds are useful in the treatment of psychotic disorders.

    摘要翻译： 本发明涉及式（I）化合物，其任何对映异构体或其任何混合物或其药学上可接受的酸加成盐，其中R 1，R 2，R 3，R 4，R 11，R 12，R 13，R 14和R 15各自 氰基，氨基，酰基，烷基氨基，二烷基氨基，氨基羰基或酰氨基; R5是氢，烷基，烷氧基烷基或苯基烷基; X是-CH 2 -Z-，Z-CH 2 - ，NH-CO - ， - CO-NH-或-CH = CH-; 其中Z是O，S，CH 2或NH; Y是O，-CH 2 -W-，-W-CH 2 - ; 其中W是O或S; 并且n为0,1或2.该化合物可用于治疗精神病。

    Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine D4 receptor antagonists
    29.
    发明授权
    Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine D4 receptor antagonists 失效
    二取代的吗啉，氧氮杂或硫氮衍生物，其制备及其作为多巴胺D4受体拮抗剂的用途

    公开(公告)号：US06207662B1

    公开(公告)日：2001-03-27

    申请号：US09242693

    申请日：1999-02-23

    申请人： Oskar Axelsson ,  Dan Peters ,  Jorgen Scheel-Kruger ,  Elsebet Ostergaard Nielsen

    发明人： Oskar Axelsson ,  Dan Peters ,  Jorgen Scheel-Kruger ,  Elsebet Ostergaard Nielsen

    IPC分类号： A61K3155

    CPC分类号： C07D265/30 ,  C07D267/10 ,  C07D413/06

    摘要： The present invention relates to compounds of formula (I), any of it enantiomers, or any mixture thereof, or a pharmaceutically acceptable acid addition salt thereof, wherein R1, R2, R3, R4, R11, R12, R13, R14 and R15 each independently are hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, nitro, cyano, amino, acyl, alkylamino, dialkylamino, aminocarbonyl, or acylamino; R5 is hydrogen, alkyl, alkoxyalkyl, or phenylalkyl; X is —CH2—Z—, Z—CH2—, NH—CO—, —CO—NH—, or —CH═CH—; wherein Z is O, S, CH2, or NH; Y is O, —CH2—W—, —W—CH2—; wherein W is O, or S; and n is 0, 1 or 2. The compounds are useful in the treatment of psychotic disorders.

    摘要翻译： 本发明涉及式（I）化合物，其任何对映异构体或其任何混合物或其药学上可接受的酸加成盐，其中R 1，R 2，R 3，R 4，R 11，R 12，R 13，R 14和R 15各自 氰基，氨基，酰基，烷基氨基，二烷基氨基，氨基羰基或酰氨基; R5是氢，烷基，烷氧基烷基或苯基烷基; X是-CH 2 -Z-，Z-CH 2 - ，NH-CO - ， - CO-NH-或-CH = CH-; 其中Z是O，S，CH 2或NH; Y是O，-CH 2 -W-，-W-CH 2 - ; 其中W是O或S; 并且n为0,1或2.该化合物可用于治疗精神病。

    Novel aryl ureido benzoic acid derivatives and their use
    30.
    发明申请
    Novel aryl ureido benzoic acid derivatives and their use 失效
    新型芳基脲基苯甲酸衍生物及其用途

    公开(公告)号：US20060069255A1

    公开(公告)日：2006-03-30

    申请号：US10535683

    申请日：2003-11-10

    申请人： Jon Valgeirsson ,  Elsebet Nielsen ,  Dan Peters

    发明人： Jon Valgeirsson ,  Elsebet Nielsen ,  Dan Peters

    IPC分类号： C07D271/06 ,  C07D211/82

    CPC分类号： C07D213/75 ,  C07C275/42 ,  C07C309/51 ,  C07C2603/18 ,  C07D209/40 ,  C07D231/56 ,  C07D257/04 ,  C07D271/07 ,  C07D317/66 ,  C07D333/36

    摘要： This invention relates to novel aryl ureido benzoic acid derivatives useful as selective and non-competitive antagonists of the ionotropic GluR5 receptor. Due to their biological activity, the aryl ureido derivatives of the invention are considered useful for treating diseases that are responsive to modulation of an aspartate or a glutamate receptor. Moreover the invention provides chemical compounds for use according to the invention, as well as pharmaceutical compositions comprising the chemical compounds, and methods of treating diseases or disorders or conditions responsive to modulation of an aspartate or a glutamate receptor.

    摘要翻译： 本发明涉及可用作离子型GluR5受体的选择性和非竞争性拮抗剂的新型芳基脲基苯甲酸衍生物。 由于其生物学活性，本发明的芳基脲基衍生物被认为可用于治疗对天冬氨酸或谷氨酸受体的调节有反应的疾病。 此外，本发明提供了根据本发明使用的化合物，以及包含化合物的药物组合物，以及治疗对天冬氨酸或谷氨酸受体的调节作用的疾病或病症或病症的方法。