公开(公告)号：US20070142450A1

公开(公告)日：2007-06-21

申请号：US10590104

申请日：2005-03-16

申请人： Bjarne Dahl ,  Dan Peters ,  Gunnar Olsen ,  Tino Jorgensen ,  Daniel Timmermann

发明人： Bjarne Dahl ,  Dan Peters ,  Gunnar Olsen ,  Tino Jorgensen ,  Daniel Timmermann

IPC分类号： A61K31/4015 ,  A61K31/40 ,  C07D207/40 ,  C07D207/04

CPC分类号： C07C275/30 ,  C07C275/34 ,  C07C275/40 ,  C07D207/04 ,  C07D207/40

摘要： This invention relates to novel urea derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

摘要翻译： 本发明涉及新的尿素衍生物，其被发现是烟碱乙酰胆碱受体的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

公开(公告)号：US08022081B2

公开(公告)日：2011-09-20

申请号：US11667316

申请日：2005-12-16

申请人： Dan Peters ,  Gunnar Olsen ,  Elsebet Østergaard Nielsen

发明人： Dan Peters ,  Gunnar Olsen ,  Elsebet Østergaard Nielsen

IPC分类号： A61K31/44

CPC分类号： C07D453/02

摘要： This invention relates to novel naphthyl substituted azabicyclo derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新的萘基取代的氮杂二环衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

公开(公告)号：US20080146582A1

公开(公告)日：2008-06-19

申请号：US11884350

申请日：2006-02-13

申请人： Dan Peters ,  Daniel B Timmermann ,  Gunnar Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring

发明人： Dan Peters ,  Daniel B Timmermann ,  Gunnar Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring

IPC分类号： A61K31/501 ,  C07D401/14 ,  C07D471/08 ,  A61K31/439 ,  A61P25/28 ,  A61P25/18 ,  A61P25/24 ,  A61P25/00 ,  A61P25/32 ,  A61P25/34 ,  A61P25/36

CPC分类号： C07D471/08 ,  C07D401/14 ,  C07D487/08

摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

摘要翻译： 本发明涉及新的二氮杂双环芳基衍生物，其在烟碱乙酰胆碱受体和单胺受体和转运蛋白的调节剂中被发现是胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

公开(公告)号：US07662812B2

公开(公告)日：2010-02-16

申请号：US11884350

申请日：2006-02-13

申请人： Dan Peters ,  Daniel B Timmermann ,  Gunnar Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring

发明人： Dan Peters ,  Daniel B Timmermann ,  Gunnar Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring

IPC分类号： A61K31/551 ,  A61K31/501 ,  C07D487/08 ,  C07D245/02 ,  C07D207/325 ,  C07D209/08 ,  C07D211/60 ,  C07C69/67 ,  A61P25/02 ,  A61P25/30

CPC分类号： C07D471/08 ,  C07D401/14 ,  C07D487/08

摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

摘要翻译： 本发明涉及新的二氮杂双环芳基衍生物，其在烟碱乙酰胆碱受体和单胺受体和转运蛋白的调节剂中被发现是胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

公开(公告)号：US20060217415A1

公开(公告)日：2006-09-28

申请号：US10568148

申请日：2004-06-29

申请人： Dan Peters ,  Gunnar Olsen ,  Elsbert Nielsen ,  Philip Ahring ,  Tino Jorgensen ,  Michael Schrimpf ,  Kevin Sippy

发明人： Dan Peters ,  Gunnar Olsen ,  Elsbert Nielsen ,  Philip Ahring ,  Tino Jorgensen ,  Michael Schrimpf ,  Kevin Sippy

IPC分类号： A61K31/4745 ,  C07D453/02

CPC分类号： C07D453/02

摘要： This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

摘要翻译： 本发明涉及新的奎宁环衍生物及其作为药物的用途。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。