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11 条记录 (耗时 0.029 秒)

    Novel urea derivatives and their medical use
    1.
    发明申请
    Novel urea derivatives and their medical use 审中-公开
    新型尿素衍生物及其医疗用途

    公开(公告)号：US20070142450A1

    公开(公告)日：2007-06-21

    申请号：US10590104

    申请日：2005-03-16

    申请人： Bjarne Dahl ,  Dan Peters ,  Gunnar Olsen ,  Tino Jorgensen ,  Daniel Timmermann

    发明人： Bjarne Dahl ,  Dan Peters ,  Gunnar Olsen ,  Tino Jorgensen ,  Daniel Timmermann

    IPC分类号： A61K31/4015 ,  A61K31/40 ,  C07D207/40 ,  C07D207/04

    CPC分类号： C07C275/30 ,  C07C275/34 ,  C07C275/40 ,  C07D207/04 ,  C07D207/40

    摘要： This invention relates to novel urea derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的尿素衍生物，其被发现是烟碱乙酰胆碱受体的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Novel Azabicyclic Aryl Derivatives
    2.
    发明申请
    Novel Azabicyclic Aryl Derivatives 失效
    新型氮杂环芳基衍生物

    公开(公告)号：US20070203117A1

    公开(公告)日：2007-08-30

    申请号：US10591871

    申请日：2005-05-10

    申请人： Dan Peters ,  Gunnar Olsen ,  Elsebet Nielsen ,  Tino Jorgensen ,  Daniel Timmermann

    发明人： Dan Peters ,  Gunnar Olsen ,  Elsebet Nielsen ,  Tino Jorgensen ,  Daniel Timmermann

    IPC分类号： A61K31/55 ,  A61K31/4745 ,  A61K31/407 ,  C07D453/02

    CPC分类号： C07D453/02

    摘要： This invention relates to novel azabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及在尼古丁乙酰胆碱受体中被发现是胆碱能配体的新的氮杂双环芳基衍生物。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Novel Azabicyclic Aryl Derivatives and Their Medical Use
    3.
    发明申请
    Novel Azabicyclic Aryl Derivatives and Their Medical Use 失效
    新型Azabicycyl Aryl衍生物及其医疗用途

    公开(公告)号：US20070299082A1

    公开(公告)日：2007-12-27

    申请号：US11663152

    申请日：2005-10-14

    申请人： Dan Peters ,  Daniel Timmermann ,  Gunnar Olsen ,  Elsebet Nielsen ,  Tino Jorgensen

    发明人： Dan Peters ,  Daniel Timmermann ,  Gunnar Olsen ,  Elsebet Nielsen ,  Tino Jorgensen

    IPC分类号： A61K31/439 ,  A61K31/501 ,  A61P25/18 ,  C07D401/02 ,  C07D401/14 ,  C07D453/02

    CPC分类号： C07D453/02

    摘要： This invention relates to novel azabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的氮杂双环芳基衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Novel Diazabicyclic Aryl Derivatives as Cholinergy Ligands
    4.
    发明申请
    Novel Diazabicyclic Aryl Derivatives as Cholinergy Ligands 失效
    新二氮杂双环芳烃衍生物作为胆碱能配体

    公开(公告)号：US20070265271A1

    公开(公告)日：2007-11-15

    申请号：US11663967

    申请日：2005-11-29

    申请人： Dan Peters ,  Daniel Timmermann ,  Gunnar Olsen ,  Elsebet Nielsen ,  Tino Jorgensen

    发明人： Dan Peters ,  Daniel Timmermann ,  Gunnar Olsen ,  Elsebet Nielsen ,  Tino Jorgensen

    IPC分类号： A61K31/4995 ,  A61P25/00 ,  A61P25/16 ,  A61P25/24 ,  A61P3/00 ,  A61P3/04 ,  A61P43/00 ,  C07D471/08

    CPC分类号： C07D487/08

    摘要： This invention relates to novel diazabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的二氮杂双环芳基衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Novel quinuclidine derivatives and their pharmaceutical use
    5.
    发明申请
    Novel quinuclidine derivatives and their pharmaceutical use 失效
    新型奎宁环衍生物及其药物用途

    公开(公告)号：US20060217415A1

    公开(公告)日：2006-09-28

    申请号：US10568148

    申请日：2004-06-29

    申请人： Dan Peters ,  Gunnar Olsen ,  Elsbert Nielsen ,  Philip Ahring ,  Tino Jorgensen ,  Michael Schrimpf ,  Kevin Sippy

    发明人： Dan Peters ,  Gunnar Olsen ,  Elsbert Nielsen ,  Philip Ahring ,  Tino Jorgensen ,  Michael Schrimpf ,  Kevin Sippy

    IPC分类号： A61K31/4745 ,  C07D453/02

    CPC分类号： C07D453/02

    摘要： This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的奎宁环衍生物及其作为药物的用途。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Novel 1,4-diazabicycloalkane derivatives, their preparation and use
    6.
    发明申请
    Novel 1,4-diazabicycloalkane derivatives, their preparation and use 有权
    新型1,4-二氮杂双环链烷烃衍生物，其制备和应用

    公开(公告)号：US20060122172A1

    公开(公告)日：2006-06-08

    申请号：US10528361

    申请日：2003-09-29

    申请人： Dan Peters ,  Gunnar Olsen ,  Elsebet Nielsen ,  Tino Jorgensen ,  Philip Ahring

    发明人： Dan Peters ,  Gunnar Olsen ,  Elsebet Nielsen ,  Tino Jorgensen ,  Philip Ahring

    IPC分类号： C07D487/04 ,  A61K31/551

    CPC分类号： C07D471/08 ,  C07D487/04

    摘要： This invention relates to novel 1,4-diazabicycloalkane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的1,4-二氮杂双环链烷烃衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Novel diazabicyclic aryl derivatives
    10.
    发明申请
    Novel diazabicyclic aryl derivatives 有权
    新型二氮杂双环芳基衍生物

    公开(公告)号：US20060148789A1

    公开(公告)日：2006-07-06

    申请号：US10547157

    申请日：2004-02-04

    申请人： Dan Peters ,  Elsebet Nielsen ,  Tino Jorgensen ,  Philip Ahring

    发明人： Dan Peters ,  Elsebet Nielsen ,  Tino Jorgensen ,  Philip Ahring

    IPC分类号： A61K31/551 ,  A61K31/498 ,  C07D487/04

    CPC分类号： C07D471/08

    摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及在尼古丁乙酰胆碱受体中被发现是胆碱能配体的新的二氮杂双环芳基衍生物。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。