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    DEVICES AND METHODS FOR DYNAMIC FOCUSING MOVEMENT
    22.
    发明申请
    DEVICES AND METHODS FOR DYNAMIC FOCUSING MOVEMENT 审中-公开
    用于动态聚焦运动的装置和方法

    公开(公告)号：US20130338767A1

    公开(公告)日：2013-12-19

    申请号：US13976406

    申请日：2011-12-28

    申请人： Rudy Mazzocchi ,  Ronald David Blum

    发明人： Rudy Mazzocchi ,  Ronald David Blum

    IPC分类号： A61F2/16

    CPC分类号： A61F2/1635 ,  A61F2/1629 ,  A61F2/1648 ,  A61F2002/1681 ,  A61F2210/0014 ,  A61F2210/0023 ,  A61F2210/0033 ,  A61F2210/0038 ,  A61F2250/0002

    摘要： An implantable ophthalmic device with one or more optical elements coupled to one or more shape-memory members provides dynamically variable optical power to restore lost accommodation in individuals suffering from presbyopia or aphakia. Running current from a power supply through the shape-memory members causes the shape-memory members to heat up. Once the current heats the shape-memory members past a forward phase-transition temperature, the shape-memory members change shape, which, in turn, causes the optical element(s) to move, yielding a corresponding change in effective optical power. Cooling the shape-memory members (e.g., by reducing or stopping the flow of current) below a reverse phase-transition temperature causes the shape-memory members to return to their original shape, which, in turn, restoring the optical element(s) to their original positions and returning the effective optical power to its original level.

    摘要翻译： 具有耦合到一个或多个形状记忆部件的一个或多个光学元件的可植入眼科装置提供动态可变的光学功率，以恢复患有老花眼或无晶状体的个体的失去的适应性。 从电源通过形状记忆部件运行电流导致形状记忆部件加热。 一旦电流加热形状记忆元件超过正向相变温度，则形状记忆元件改变形状，这又导致光学元件移动，产生有效光功率的相应变化。 将形状记忆体（例如，通过减少或停止电流的流动）冷却到反相转变温度以下，导致形状记忆元件返回到其原始形状，这反过来恢复光学元件， 到原来的位置，并将有效光功率恢复到原来的水平。

    IMPLANTABLE OPHTHALMIC DEVICE WITH AN ASPHERIC LENS
    23.
    发明申请
    IMPLANTABLE OPHTHALMIC DEVICE WITH AN ASPHERIC LENS 审中-公开
    具有双面镜片的可植入手术装置

    公开(公告)号：US20130261744A1

    公开(公告)日：2013-10-03

    申请号：US13701432

    申请日：2011-05-31

    申请人： Amitava Gupta ,  Nicholas Wooder ,  Ronald D. Blum ,  Rudy Mazzocchi ,  Urban Schnell

    发明人： Amitava Gupta ,  Nicholas Wooder ,  Ronald D. Blum ,  Rudy Mazzocchi ,  Urban Schnell

    IPC分类号： A61F2/16

    CPC分类号： A61F2/1616 ,  A61B3/10 ,  A61B5/0031 ,  A61B5/0496 ,  A61B2560/0219 ,  A61F2/1624 ,  A61F2/1627 ,  A61F2/164 ,  A61F2/1648 ,  A61F2250/0002

    摘要： Implantable ophthalmic devices with aspheric lenses and dynamic electro-active elements offer excellent depth of field and image quality while providing high optical throughput. An exemplary implantable ophthalmic device includes an aspheric lens with a negative spherical aberration that varies with radius. The aspheric lens can have peak optical powers at its geometric centers surrounded by a region of varying optical power (with varying slope) that extends radially from its center. When implanted, these aspheric lenses provide an incremental optical power that varies as a function of pupil diameter, which changes with object distance, for viewing far, intermediate, and near objects. The aspheric lens may also bonded or integrally formed with a spherical lens that provides fixed optical power for viewing far objects and/or a dynamic electro-active element that with two or more states (e.g., on and off) for increasing the effective optical power when viewing near objects.

    摘要翻译： 具有非球面透镜和动态电活性元件的可植入眼科装置提供优异的景深和图像质量，同时提供高的光学吞吐量。 示例性的可植入眼科装置包括具有随半径变化的负球面像差的非球面透镜。 非球面透镜在其几何中心处可以具有由其从其中心径向延伸的具有变化的光焦度（具有变化的斜率）的区域包围的峰值光焦度。 当植入时，这些非球面透镜提供增加的光学功率，其随瞳孔直径的变化而变化，瞳孔直径随物体距离而变化，用于观察远，中和近物体。 非球面透镜也可以与提供用于观察远物体的固定光焦度的球形透镜结合或整体形成，和/或具有两个或更多个状态（例如，接通和关断）以增加有效光功率的动态电活性元件 查看近物体时。

    Stent and method for drug delivery from stents
    30.
    发明申请
    Stent and method for drug delivery from stents 审中-公开
    从支架药物输送的支架和方法

    公开(公告)号：US20050278014A9

    公开(公告)日：2005-12-15

    申请号：US10078622

    申请日：2002-02-19

    申请人： Wolfgang Daum ,  Monica Anderson ,  Rudy Mazzocchi

    发明人： Wolfgang Daum ,  Monica Anderson ,  Rudy Mazzocchi

    IPC分类号： A61F2/00 ,  A61F2/82 ,  A61L31/16 ,  A61M25/00 ,  A61F2/06

    CPC分类号： A61F2/82 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/416 ,  A61M2025/0057 ,  A61M2205/36

    摘要： A method for controlling the activity of drugs on or in drug-coated or drug-loaded implantable devices, such as stents or other metallic devices, uses non-invasive, inductive heating of such device. The heating of a device, such as stent, can be used to release drugs applied to the stent in release layers, to activate drugs on the stent that have little or no activity at body temperature and to enhance for defined periods the reaction environment at the stent for drug-adjacent tissue interactions. Reverse effects of deactivation of drugs upon heating are also possible.

    摘要翻译： 用于控制药物涂覆或药物加载的可植入装置（例如支架或其他金属装置）上或其中的药物的活性的方法使用这种装置的非侵入式感应加热。 可以使用诸如支架的装置的加热来释放在释放层中施加到支架上的药物，以激活在体内几乎没有或没有活性的支架上的药物，并且在限定的时间段内增强在 支架用于药物相邻组织相互作用。 加热时药物失活的逆效应也是可能的。