公开(公告)号：US20070254307A1

公开(公告)日：2007-11-01

申请号：US11739578

申请日：2007-04-24

申请人： David Kita

发明人： David Kita

IPC分类号： G06F19/00 ,  G01N33/53

CPC分类号： G16B15/00

摘要： A method and apparatus for estimating a location of one or more active sites on a target biopolymer molecular subset. The collective results for the likelihood of molecular combination between a collection of molecular subsets and the target biopolymer molecular subset are analyzed. The computational method utilizes an electrostatic affinity score for different configurations between the target biopolymer molecular subset and the molecular subsets of the collection. Favorable configurations are determined based on the affinity scores. These favorable configurations are then used to determine interaction loci, which are associated with regions of the target biopolymer molecular subset having a high likelihood of molecular combination. The locations of the active sites are then estimated from the interaction loci.

摘要翻译： 一种用于估计靶生物聚合物分子子集上的一个或多个活性位点的位置的方法和装置。 分析了分子子集合和目标生物聚合物分子子集之间的分子组合的可能性的集合结果。 计算方法利用目标生物聚合物分子子集与集合的分子子集之间的不同配置的静电亲和力分数。 基于亲和度分数确定有利的配置。 然后使用这些有利的构型来确定与具有高分子组合可能性的靶生物聚合物分子子集的区域相关的相互作用位点。 然后从相互作用位点估计活动位点的位置。

公开(公告)号：US20060034373A1

公开(公告)日：2006-02-16

申请号：US11213334

申请日：2005-08-26

申请人： Michial Gunter ,  David Kita ,  Oliver Shih ,  Carroll Gossett

发明人： Michial Gunter ,  David Kita ,  Oliver Shih ,  Carroll Gossett

IPC分类号： H04N7/12 ,  H04N11/04 ,  H04B1/66 ,  H04N11/02

CPC分类号： H04N19/543

摘要： A method and apparatus for estimating the motion of an image region (the “center” region) from a source video frame to a target video frame. The motion estimation is locally constrained in that the estimated motion of the “center region” is affected by the estimated motion of neighboring regions. Advantageously, this may reduce common motion matching problems such as false and ambiguous matches. In one embodiment, the locally-constrained motion estimation may be implemented by biasing an error map of the center region using error maps of the neighboring regions.

公开(公告)号：US20050191656A1

公开(公告)日：2005-09-01

申请号：US10987549

申请日：2004-11-12

申请人： Radoje Drmanac ,  Snezana Drmanac ,  David Kita ,  Cory Cooke ,  Chongjun Xu

发明人： Radoje Drmanac ,  Snezana Drmanac ,  David Kita ,  Cory Cooke ,  Chongjun Xu

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12P19/34 ,  C12Q1/68

CPC分类号： C12Q1/6874 ,  C12Q2537/165

摘要： The invention provides methods for sequencing by hybridization (SBH) using pools of probes that allow greater efficiency in conducting SBH by reducing the number of separate measurements of hybridization signals required to identify each particular nucleotide in a target nucleic acid sequence. The invention also provides pools and sets of pools of probes, as well as methods of generating pools of probes.

摘要翻译： 本发明提供了通过杂交（SBH）进行测序的方法，所述探针池通过减少鉴定靶核酸序列中的每个特定核苷酸所需的杂交信号的单独测量的数量，从而能够更高效地传导SBH。 本发明还提供了一组探针池和一组探测池的生成方法。