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    Aminopyridine-containing thiourea inhibitors of herpes viruses
    21.
    发明授权
    Aminopyridine-containing thiourea inhibitors of herpes viruses 失效
    含有氨基吡啶的疱疹病毒的硫脲抑制剂

    公开(公告)号：US06262090B1

    公开(公告)日：2001-07-17

    申请号：US09444896

    申请日：1999-11-22

    申请人： Jonathan Bloom ,  Martin DiGrandi ,  Russell Dushin ,  Stanley Lang ,  Bryan O'Hara

    发明人： Jonathan Bloom ,  Martin DiGrandi ,  Russell Dushin ,  Stanley Lang ,  Bryan O'Hara

    IPC分类号： A61K3144

    CPC分类号： C07D333/02 ,  C07D207/34 ,  C07D211/72 ,  C07D213/44 ,  C07D235/26 ,  C07D307/02

    摘要： Compounds of the formula wherein A is heteroaryl; R9-R12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R9 and R10 or R11 and R12 may be taken together to form aryl of 5 to 7 carbon atoms; W is O, NR6, or is absent; G is aryl or heteroaryl; and X is a bond X is a bond, —NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; and J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; or a pharmaceutical acceptable salt thereof, useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

    摘要翻译： 式Ⅳa的化合物是杂芳基; R 9 -R 12独立地是氢，1至4个碳原子的烷基，1至4个碳原子的全卤代烷基，卤素，1至4个碳原子的烷氧基或氰基，或R 9和R 10或R 11和 R 12可以一起形成5至7个碳原子的芳基; W是O，NR 6或不存在; G是芳基或杂芳基; X为键，X为碳原子数为1〜6的烷基，碳原子数为1〜6的烯基，碳原子数为1〜6的烷氧基，碳原子数为1〜6的硫代烷基，碳原子数为1〜6的烷基氨基 原子或（CH）J; 且J为1至6个碳原子的烷基，3至7个碳原子的环烷基，苯基或苄基; andn是1〜6的整数; 或其药学上可接受的盐，其可用于治疗与疱疹病毒相关的疾病，包括人巨细胞病毒，单纯疱疹病毒，爱泼斯坦 - 巴尔病毒，水痘带状疱疹病毒，人疱疹病毒-6和-7以及卡波西疱疹病毒。