公开(公告)号：US20230345986A1

公开(公告)日：2023-11-02

申请号：US18014789

申请日：2021-10-26

申请人： Firmenich SA

发明人： Wen-Juan XIANG ,  Dan-Ting YIN

IPC分类号： A23L27/00 ,  C07C225/16 ,  C07D317/50 ,  C07D207/04 ,  C07D207/325 ,  C07D207/18 ,  C07D211/36 ,  C07D211/72

CPC分类号： A23L27/88 ,  C07C225/16 ,  C07D317/50 ,  C07D207/04 ,  C07D207/325 ,  C07D207/18 ,  C07D211/36 ,  C07D211/72

摘要： The present disclosure generally provides conjugates diynes, particularly 6,8-diyne amides, and the use of such compounds and related compounds as flavor modifiers. In some aspects, the disclosure provides compositions that include such conjugated diynes, such as compositions that include such conjugated diynes and one or more additional compounds, such as a sweetener, salt, a glutamate, an arginate, and the like. In some other aspects, the disclosure provides methods of reducing or eliminating the amount of sweetener, salt, glutamate, or arginate in a food or beverage product.

公开(公告)号：US10059669B2

公开(公告)日：2018-08-28

申请号：US15524479

申请日：2015-11-09

申请人： H. Lundbeck A/S

发明人： Karsten Juhl ,  Lena Tagmose ,  Mauro Marigo

IPC分类号： C07D211/72 ,  C07D401/12 ,  C07D413/12 ,  A61K31/4427 ,  C07D417/12 ,  C07B59/00

CPC分类号： C07D211/72 ,  C07B59/002 ,  C07B2200/05 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

摘要： The present invention is directed to compounds according to Formula (I) which compounds are inhibitors of the BACE1 enzyme. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders for 5 which the reduction of Aβ deposits is beneficial such as Alzheimer's disease.

公开(公告)号：US10011596B2

公开(公告)日：2018-07-03

申请号：US15233463

申请日：2016-08-10

申请人： H. Lundbeck A/S

发明人： Karsten Juhl ,  Lena Tagmose ,  Mauro Marigo

IPC分类号： C07D417/12 ,  C07B59/00 ,  C07D211/72 ,  C07D401/12 ,  C07D413/12 ,  C07D211/76

CPC分类号： C07D401/12 ,  C07B59/002 ,  C07B2200/05 ,  C07D211/72 ,  C07D211/76 ,  C07D413/12 ,  C07D417/12

摘要： The present invention provides compounds of Formula I for the treatment of neurodegenerative or cognitive diseases. The method further provides for piperidine-2-one and piperidine-2-thione intermediates to compounds of formula I.

公开(公告)号：US20170334853A1

公开(公告)日：2017-11-23

申请号：US15631822

申请日：2017-06-23

申请人： The Regents of the University of Michigan

发明人： Haoming Zhang ,  Paul Hollenberg

IPC分类号： C07D211/72 ,  C07D405/12 ,  C07D401/12 ,  A61K45/06 ,  A61K31/4545 ,  A61K31/501 ,  A61K47/54 ,  A61K31/4525 ,  A61K31/445 ,  A61K47/64 ,  C07K5/093 ,  A61K38/06

CPC分类号： C07D211/72 ,  A61K31/445 ,  A61K31/4525 ,  A61K31/4545 ,  A61K31/501 ,  A61K38/06 ,  A61K45/06 ,  A61K47/54 ,  A61K47/542 ,  A61K47/545 ,  A61K47/64 ,  A61P9/00 ,  C07D401/12 ,  C07D405/12 ,  C07K5/0819 ,  A61K2300/00

摘要： This invention is in the field of medicinal chemistry. In particular, the invention relates to mixed disulfide conjugates of thienopyridine compounds, and their use as therapeutics for the treatment, amelioration, and prevention of cardiovascular diseases.

公开(公告)号：US20170283434A1

公开(公告)日：2017-10-05

申请号：US15631613

申请日：2017-06-23

申请人： OPKO Health, Inc.

发明人： Sunil Paliwal ,  Gregory A. Reichard ,  Cheng Wang ,  Dong Xiao ,  Hon-Chung Tsui ,  Neng-Yang Shih ,  Juan D. Arredondo ,  Michelle Laci Wrobleski ,  Anandan Palani

IPC分类号： C07D498/10 ,  C07D211/56 ,  C07D487/10 ,  C07D401/04 ,  A61K31/454 ,  A61K31/166 ,  A61K31/451 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/537 ,  C07D211/60 ,  A61K31/573

CPC分类号： C07D498/10 ,  A61K31/166 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/537 ,  A61K31/5377 ,  A61K31/573 ,  A61K45/06 ,  C07D207/14 ,  C07D207/50 ,  C07D211/28 ,  C07D211/32 ,  C07D211/42 ,  C07D211/56 ,  C07D211/60 ,  C07D211/72 ,  C07D211/76 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D413/10 ,  C07D413/12 ,  C07D471/10 ,  C07D487/10 ,  C07D491/10 ,  C07D513/10

摘要： A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.

公开(公告)号：US09758527B2

公开(公告)日：2017-09-12

申请号：US15307719

申请日：2015-05-01

申请人： HYUNDAI PHARM CO., LTD.

发明人： Jin Yang ,  Jinwoong Kim ,  Han Kyu Lee ,  Jae Hyun Kim ,  Chang Mo Son ,  Kyu Hwan Lee ,  Jeongun Hwang ,  Hyung-Ho Choi ,  Daehoon Kim ,  Jaekeol Rhee

IPC分类号： C07D491/113 ,  C07D211/22 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D487/10

CPC分类号： C07D491/113 ,  C07D211/22 ,  C07D211/46 ,  C07D211/58 ,  C07D211/62 ,  C07D211/72 ,  C07D211/74 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/12 ,  C07D487/10

摘要： The present invention relates to: a cyclohexene derivative; a preparation method therefor; and a pharmaceutical composition for preventing or treating metabolic diseases, containing the same as an active ingredient. The cyclohexene derivative according to the present invention increases the intracellular activity of cyclic adenosine monophosphate (cAMP) by activating G protein-coupled receptor 119 (GPR-119) and simultaneously exhibits weight loss and hypoglycemic effects by inducing the release of glucagon-like peptide-1 (GLP-1), which is a neuroendocrine protein, and thus can be useful as a pharmaceutical composition for preventing or treating metabolic diseases such as obesity, type 1 diabetes, type 2 diabetes, inadequate glucose tolerance, insulin resistance, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, dyslipidemia and syndrome X.

公开(公告)号：US09718778B2

公开(公告)日：2017-08-01

申请号：US14758736

申请日：2014-01-06

申请人： The Regents of the University of Michigan

发明人： Haoming Zhang ,  Paul Hollenberg

IPC分类号： C07D211/72 ,  C07D405/12 ,  C07K5/093 ,  A61K31/445 ,  A61K38/06 ,  A61K47/48 ,  A61K31/501 ,  C07D401/12 ,  A61K45/06 ,  A61K31/4525 ,  A61K31/4545

CPC分类号： C07D211/72 ,  A61K31/445 ,  A61K31/4525 ,  A61K31/4545 ,  A61K31/501 ,  A61K38/06 ,  A61K45/06 ,  A61K47/54 ,  A61K47/542 ,  A61K47/545 ,  A61K47/64 ,  A61P9/00 ,  C07D401/12 ,  C07D405/12 ,  C07K5/0819 ,  A61K2300/00

摘要： This invention is in the field of medicinal chemistry. In particular, the invention relates to mixed disulfide conjugates of thienopyridine compounds, and their use as therapeutics for the treatment, amelioration, and prevention of cardiovascular diseases.

公开(公告)号：US09688693B2

公开(公告)日：2017-06-27

申请号：US14341097

申请日：2014-07-25

申请人： OPKO Health, Inc.

发明人： Sunil Paliwal ,  Gregory A. Reichard ,  Cheng Wang ,  Dong Xiao ,  Hon-Chung Tsui ,  Neng-Yang Shih ,  Juan D. Arredondo ,  Michelle Laci Wrobleski ,  Anandan Palani

IPC分类号： C07D498/10 ,  A61K31/40 ,  C07D207/14 ,  C07D211/28 ,  C07D211/32 ,  C07D211/42 ,  C07D211/56 ,  C07D211/60 ,  C07D211/72 ,  C07D211/76 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D413/10 ,  C07D413/12 ,  C07D471/10 ,  C07D487/10 ,  C07D491/10 ,  C07D513/10 ,  A61K31/4025 ,  A61K31/438 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  A61K45/06 ,  C07D207/50

CPC分类号： C07D498/10 ,  A61K31/166 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/451 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/537 ,  A61K31/5377 ,  A61K31/573 ,  A61K45/06 ,  C07D207/14 ,  C07D207/50 ,  C07D211/28 ,  C07D211/32 ,  C07D211/42 ,  C07D211/56 ,  C07D211/60 ,  C07D211/72 ,  C07D211/76 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D413/10 ,  C07D413/12 ,  C07D471/10 ,  C07D487/10 ,  C07D491/10 ,  C07D513/10

摘要： A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.

公开(公告)号：US20170057914A1

公开(公告)日：2017-03-02

申请号：US15349297

申请日：2016-11-11

申请人： BAYER CROPSCIENCE AG ,  BAYER INTELLECTUAL PROPERTY GMBH

发明人： Adeline KOEHLER ,  Bernd ALIG ,  Angela BECKER ,  Arnd VOERSTE ,  Ulrich GOERGENS ,  Reiner FISCHER ,  Wahed Ahmed MORADI ,  Silvia CEREZO-GALVEZ ,  Julia Johanna HAHN ,  Kerstin ILG ,  Hans-Georg SCHWARZ ,  Takuya GOMIBUCHI ,  Masahito ITO ,  Daiei YAMAZAKI ,  Katsuhiko SHIBUYA ,  Eiichi SHIMOJO

IPC分类号： C07C323/41 ,  C07C323/45 ,  C07C317/40 ,  C07C315/02 ,  C07C323/36 ,  C07D333/38 ,  C07D207/34 ,  C07D307/68 ,  C07C319/14 ,  C07D213/78 ,  C07D295/13 ,  C07D241/24 ,  C07D207/22 ,  C07D279/06 ,  C07D263/28 ,  C07D277/16 ,  C07D277/54 ,  C07C335/16 ,  C07D239/28 ,  C07D305/08 ,  C07D211/98 ,  C07D307/24 ,  C07D277/38 ,  C07D331/04 ,  C07D333/48 ,  C07D211/38 ,  C07D401/06 ,  C07D285/08 ,  C07C319/20

CPC分类号： A01N41/10 ,  A01N41/12 ,  A01N43/08 ,  A01N43/10 ,  A01N43/36 ,  A01N43/40 ,  A01N43/60 ,  A01N43/84 ,  A01N43/86 ,  C07C315/02 ,  C07C317/34 ,  C07C317/40 ,  C07C319/14 ,  C07C319/20 ,  C07C323/36 ,  C07C323/41 ,  C07C323/44 ,  C07C323/45 ,  C07C335/16 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D207/22 ,  C07D207/34 ,  C07D211/38 ,  C07D211/72 ,  C07D211/98 ,  C07D213/61 ,  C07D213/78 ,  C07D239/28 ,  C07D241/24 ,  C07D263/28 ,  C07D277/16 ,  C07D277/18 ,  C07D277/38 ,  C07D277/54 ,  C07D279/06 ,  C07D285/08 ,  C07D295/125 ,  C07D295/13 ,  C07D305/08 ,  C07D307/24 ,  C07D307/68 ,  C07D331/04 ,  C07D333/38 ,  C07D333/48 ,  C07D401/06

摘要： The present invention relates to novel N-arylamide-substituted trifluoroethyl sulfide derivatives of the formula (I) in which X1, X2, X3, X4, R1, R2, R3, n have the meanings given in the description—to their use as acaricides and insecticides for controlling animal pests and to processes and intermediates for their preparation

公开(公告)号：US20160244409A1

公开(公告)日：2016-08-25

申请号：US14905217

申请日：2014-07-15

申请人： CORAL SUNSCREEN PTY LTD

发明人： Mark YORK ,  John RYAN ,  Gregory Paul SAVAGE ,  Adam Gerhard MEYER ,  Karen JARVIS

IPC分类号： C07D211/70 ,  C07D211/72 ,  C07D401/06 ,  C07D403/04 ,  C07D211/78 ,  C09D7/12 ,  C07D223/04 ,  C07F7/21 ,  A61Q17/04 ,  A61K8/49 ,  A61K8/58 ,  C09D5/32 ,  C07D405/06 ,  C07D401/04

CPC分类号： C07D211/70 ,  A61K8/4926 ,  A61K8/4946 ,  A61K8/585 ,  A61Q17/04 ,  C07D207/20 ,  C07D211/72 ,  C07D211/78 ,  C07D211/88 ,  C07D223/04 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D405/06 ,  C07F7/21 ,  C08K5/3412 ,  C08K5/3415 ,  C08K5/3432 ,  C08K5/3445 ,  C08K5/41 ,  C08K5/435 ,  C08K5/5442 ,  C09D5/32 ,  C09D7/63

摘要： There is provided a range of novel compounds which have been demonstrated to have useful UV absorbing properties. These compounds will find use in a range of applications such as active components in sunscreen formulations, paints, plastics, fabrics, glass and UV protective coatings.

摘要翻译： 提供了一系列已被证明具有有用的UV吸收性能的新型化合物。 这些化合物可用于一系列应用，例如防晒配方，油漆，塑料，织物，玻璃和UV保护涂层中的活性组分。