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21.发明申请USE OF CLEC1B FOR THE DETERMINATION OF CARDIOVASCULAR AND THROMBOTIC RISK 审中-公开CLEC1B用于确定心血管和血栓风险的应用公开(公告)号：US20100311053A1
公开(公告)日：2010-12-09
申请号：US12679547
申请日：2008-09-13
申请人： Detlef Kozian , Peter Wonerow , Matthias Herrmann
发明人： Detlef Kozian , Peter Wonerow , Matthias Herrmann
CPC分类号： G01N33/566 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N2333/7056 , G01N2500/04 , G01N2800/32 , G01N2800/50 , G01N2800/52
摘要： The use of the single nucleotide polymorphism (SNP) of the CLEC1B gene for the identification of cardiovascular and/or thrombotic disorders or of an increased risk for developing cardiovascular and/or thrombotic disorders in a biological sample taken from an individual to be examined; the use of CLEC1B for identifying substances active in preventing and/or treating cardiovascular and/or thrombotic disorders and methods for doing so.
摘要翻译： 使用CLEC1B基因的单核苷酸多态性（SNP）来鉴定从被检查个体获取的生物样品中的心血管和/或血栓形成障碍或发生心血管和/或血栓形成障碍的风险增加; 使用CLEC1B来鉴别预防和/或治疗心血管和/或血栓形成障碍的物质及其方法。
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公开(公告)号：US08329167B2
公开(公告)日：2012-12-11
申请号：US13331581
申请日：2011-12-20
申请人： Detlef Kozian , Matthias Herrmann
发明人： Detlef Kozian , Matthias Herrmann
CPC分类号： C12N9/0071
摘要： The present invention refers to human EGLN2 variants having at position 58 of the amino acid sequence a serine or a leucine and their use in the prevention or treatment of thromboembolic or coronary heart diseases, in particular stroke, prolonged reversible ischemic neurological deficit (PRIND), transitoric ischemic attack (TIA), myocardial infarction and/or early myocardial infarction.
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23.发明授权公开(公告)号：US06342376B1
公开(公告)日：2002-01-29
申请号：US09390324
申请日：1999-09-07
申请人： Detlef Kozian , Birgit Reuner
发明人： Detlef Kozian , Birgit Reuner
IPC分类号： C12D1934
CPC分类号： C12Q1/6853 , C12Q1/6809 , Y10T436/143333 , C12Q2565/102 , C12Q2525/173 , C12Q2521/107
摘要： The invention relates to a novel method for analyzing the composition of an mRNA sample and analyzing differential gene expression using two differently labeled primers, and to the use of the method. In the method for analyzing an RNA sample, a) a first primer, which is, where appropriate, labeled with a first dye, is used to prepare the first strand of a complementary DNA sample or cDNA sample from an RNA sample, b) a second primer, which is preferably labeled with a second dye, is used to prepare the second strand of this cDNA sample, c) the first primer, which is labeled with a first dye, and the second primer, which is labeled with a second dye, are used to amplify the cDNA sample, and d) the composition of the amplified, labeled cDNA sample is analyzed.
摘要翻译： 本发明涉及一种用于分析mRNA样品的组成并使用两个不同标记的引物分析差异基因表达的新方法，以及该方法的使用。 在分析RNA样品的方法中，a）在适当时用第一染料标记的第一引物用于从RNA样品制备互补DNA样品或cDNA样品的第一条链，b） 优选用第二染料标记的第二引物用于制备该cDNA样品的第二链，c）用第一染料标记的第一引物和用第二染料标记的第二引物 ，用于扩增cDNA样品，并且d）分析扩增的标记的cDNA样品的组成。
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公开(公告)号：US08071297B2
公开(公告)日：2011-12-06
申请号：US12095783
申请日：2006-11-23
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/573 , G01N2333/91215 , G01N2800/32 , G01N2800/52
摘要： The present invention refers to a method for the in vitro or in vivo diagnosis of cardiovascular diseases, in particular high blood pressure, stenosis, vessel occlusion and/or other thrombotic events, wherein the nucleotide at position 950 of a nucleic acid coding for the human ARK2 protein or the amino acid at position 298 of the human ARK2 protein of a sample of a person is determined as well as to the use of ARK2 for the development and/or production of a medicament for treating a cardiovascular disease.
摘要翻译： 本发明涉及体外或体内诊断心血管疾病，特别是高血压，狭窄，血管闭塞和/或其他血栓事件的方法，其中编码人的核酸的位置950处的核苷酸 确定ARK2蛋白或人的样品的人ARK2蛋白的298位的氨基酸以及使用ARK2来开发和/或制备治疗心血管疾病的药物。
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公开(公告)号：US20090239218A1
公开(公告)日：2009-09-24
申请号：US12095783
申请日：2006-11-23
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/573 , G01N2333/91215 , G01N2800/32 , G01N2800/52
摘要： The present invention refers to a method for the in vitro or in vivo diagnosis of cardiovascular diseases, in particular high blood pressure, stenosis, vessel occlusion and/or other thrombotic events, wherein the nucleotide at position 950 of a nucleic acid coding for the human ARK2 protein or the amino acid at position 298 of the human ARK2 protein of a sample of a person is determined as well as to the use of ARK2 for the development and/or production of a medicament for treating a cardiovascular disease.
摘要翻译： 本发明涉及体外或体内诊断心血管疾病，特别是高血压，狭窄，血管闭塞和/或其他血栓事件的方法，其中编码人的核酸的位置950处的核苷酸 确定ARK2蛋白或人的样品的人ARK2蛋白的298位的氨基酸以及使用ARK2来开发和/或制备治疗心血管疾病的药物。
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26.发明申请公开(公告)号：US20090197774A1
公开(公告)日：2009-08-06
申请号：US12089624
申请日：2006-09-30
申请人： Detlef Kozian , Matthias Herrmann
发明人： Detlef Kozian , Matthias Herrmann
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention refers to a method for the in vitro diagnosis of thromboembolic and/or coronary heart diseases, wherein the nucleotide at position 470 of a nucleic acid coding for the human EGLN2 protein or the amino acid at position 58 of the human EGLN2 protein of a sample of a person is determined.
摘要翻译： 本发明涉及体外诊断血栓栓塞和/或冠心病的方法，其中编码人EGLN2蛋白的核酸的位置470处的核苷酸或人EGLN2蛋白的58位的氨基酸 确定一个人的样本。
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27.发明授权公开(公告)号：US06602699B2
公开(公告)日：2003-08-05
申请号：US09986121
申请日：2001-11-07
IPC分类号： C12N1511
CPC分类号： C12N15/85 , C12N2830/001 , C12N2830/702
摘要： The present invention relates to a promoter, to DNA fragments containing said promoter and to the use thereof, in particular in methods for identifying substances exhibiting an activating or inhibiting action on G protein-coupled receptors.
摘要翻译： 本发明涉及包含所述启动子的DNA片段及其用途的启动子，特别是用于鉴定表现出对G蛋白偶联受体的活化或抑制作用的物质的方法。
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