公开(公告)号：US20100055790A1

公开(公告)日：2010-03-04

申请号：US12514798

申请日：2007-11-14

申请人： Eric M. Simon

发明人： Eric M. Simon

IPC分类号： C12N5/02 ,  B01L3/00 ,  C12M1/24 ,  C12M1/18 ,  B28B23/00

CPC分类号： C12M23/20 ,  C12M23/08 ,  C12M23/12 ,  C12M23/24

摘要： A cell culture apparatus consists of a vessel or array of vessels, each comprising a substantially flat bottom and substantially vertical sides, and composed of a substantially gas permeable material. The inner bottom surface of the vessel is commonly textured to provide the cells with adequate features for attachment and spreading. The vessel may include an integral annular flange which can be used to suspend the vessel from a suspensory element of a rack structure. To promote cell attachment and growth, the inner surfaces of the vessel bottom and sides may be coated with commonly available bio-active materials. Cells cultured in the system commonly grow in three dimensions for extended periods of time, and often produce significantly higher quantities of cellular products than cells grown in conventional labware.

摘要翻译： 细胞培养装置由容器或容器阵列组成，每个容器包括基本上平坦的底部和基本上垂直的侧面，并且由基本上透气的材料构成。 容器的内底表面通常是纹理化的，为细胞提供足够的附着和扩散特征。 容器可以包括整体的环形凸缘，其可以用于将容器悬挂在齿条结构的悬挂元件上。 为了促进细胞附着和生长，容器底部和侧面的内表面可以涂覆有常用的生物活性材料。 在系统中培养的细胞通常在三维中长时间生长，并且通常比常规实验器皿中生长的细胞产生显着更高量的细胞产物。

公开(公告)号：US07275888B1

公开(公告)日：2007-10-02

申请号：US11333887

申请日：2006-01-18

申请人： Marc E. Christensen ,  Eric M. Simon ,  William L. Snook

发明人： Marc E. Christensen ,  Eric M. Simon ,  William L. Snook

IPC分类号： E01F9/00 ,  E01F13/00 ,  E01F13/02 ,  E01F9/016 ,  E01F15/02 ,  E01F15/10

CPC分类号： E01F13/02 ,  E01F13/022 ,  E01F15/083 ,  E01F15/086 ,  E01F15/088

摘要： A stackable interlocking barrier system includes a first barrier having a front wall and a back wall each extending between a top wall and a floor, at least a portion of the front wall being sloped relative to the back wall. A second barrier also has a front wall and a back wall each extending between a top wall and a floor, at least a portion of the front wall being sloped relative to the back wall. The second barrier is inverted relative to the first barrier with the front wall of the second barrier seated against the front wall of the first barrier. A first connector is removably mounted on the first barrier and the second barrier so as to secure the first barrier to the second barrier.

摘要翻译： 一种可堆叠互锁屏障系统包括：第一屏障，其具有前壁和后壁，每个壁在顶壁和地板之间延伸，前壁的至少一部分相对于后壁倾斜。 第二屏障还具有前壁和后壁，其分别在顶壁和地板之间延伸，前壁的至少一部分相对于后壁倾斜。 第二屏障相对于第一屏障反转，第二屏障的前壁抵靠第一屏障的前壁。 第一连接器可移除地安装在第一屏障和第二屏障上，以便将第一屏障固定到第二屏障。

公开(公告)号：USD451196S1

公开(公告)日：2001-11-27

申请号：US29119377

申请日：2000-02-28

申请人： Randall D. Block ,  Eric M. Simon

设计人： Randall D. Block ,  Eric M. Simon

公开(公告)号：US5167625A

公开(公告)日：1992-12-01

申请号：US595087

申请日：1990-10-09

申请人： Stephen C. Jacobsen ,  Barry K. Hanover ,  Eric M. Simon ,  Tomasz Petelenz ,  Michael G. Mladejovsky

发明人： Stephen C. Jacobsen ,  Barry K. Hanover ,  Eric M. Simon ,  Tomasz Petelenz ,  Michael G. Mladejovsky

IPC分类号： A61K9/22 ,  A61M31/00

CPC分类号： A61M31/002

摘要： An implantable drug delivery system includes a housing having a plurality of compartments each of which includes an opening on one side thereof and a floor generally opposite the opening. Also included are a plurality of flexible drug containment sacks, each having a mouth circumscribing an opening in the sack, with the sack being disposed in a respective compartment with the mouth affixed to the opening of that compartment to seal the inside of the sack from the inside of the compartment and to enable holding a drug formulation in the sack. A plurality of covers are disposed over a respective compartment opening for preventing the release of drug formulation contained in the sacks in the compartment covered, until ruptured or removed. A plurality of gas generating elements are disposed at the floor of a respective compartment under the sack in that compartment and are responsive to initiation signals for producing gas to force the sacks and drug formulations against the covers to thereby rupture or remove the covers and force the formulations out of the housing. An electrical circuit supplies initiation signals to the gas generating means to initiate production of the gas and thus discharge of the drug formulation.

摘要翻译： 可植入药物输送系统包括具有多个隔室的壳体，每个隔室在其一侧包括一个开口和与开口大致相对的底板。 还包括多个柔性药物容纳袋，每个袋具有围绕袋中的开口的口，其中袋被设置在相应的隔室中，口中固定有该隔室的开口以将袋的内部从 在隔间内部，并且能够在药袋中保持药物制剂。 多个盖设置在相应的隔室开口上，用于防止包装在被覆盖的隔室中的袋中的药物制剂的释放，直到破裂或移除。 多个气体发生元件设置在该隔间中的袋下面的相应隔室的底板处，并响应于产生气体的起始信号，以迫使袋和药物制剂抵靠盖，从而破裂或移除盖并迫使 制剂出了房屋。 电路将起始信号提供给气体发生装置以启动气体的产生，从而释放药物制剂。