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公开(公告)号：US20220176278A1
公开(公告)日：2022-06-09
申请号：US17682221
申请日：2022-02-28
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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公开(公告)号：US20210260504A1
公开(公告)日：2021-08-26
申请号：US17315721
申请日：2021-05-10
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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公开(公告)号：US11040310B2
公开(公告)日：2021-06-22
申请号：US16207895
申请日：2018-12-03
Applicant: EMD Millipore Corporation
Inventor： Herbert Lutz , Joseph Parrella , Bala Raghunath
Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.
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Patent Agency Ranking
公开(公告)号：US10350518B2
公开(公告)日：2019-07-16
申请号：US14839852
申请日：2015-08-28
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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25.发明申请公开(公告)号：US20190099702A1
公开(公告)日：2019-04-04
申请号：US16208018
申请日：2018-12-03
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
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公开(公告)号：US10207225B2
公开(公告)日：2019-02-19
申请号：US14736646
申请日：2015-06-11
Applicant: EMD Millipore Corporation
Inventor： Herbert Lutz , Joseph Parrella , Bala Raghunath
Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.
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27.发明申请Processes for Filtering Liquids Using Single Pass Tangential Flow Filtration Systems and Tangential Flow Filtration Systems with Recirculation of Retentate 审中-公开使用单道切向流过滤系统过滤液体的过程和具有再渗透的切向流过滤系统公开(公告)号：US20160059160A1
公开(公告)日：2016-03-03
申请号：US14839852
申请日：2015-08-28
Applicant: EMD Millipore Corporation
Inventor： Jonathan Steen , Mikhail Kozlov , Herbert Lutz , Joseph Parrella , Elizabeth M. Goodrich , Bala Raghunath
CPC classification number: B01D29/908 , B01D29/52 , B01D29/603 , B01D61/142 , B01D61/145 , B01D61/147 , B01D63/04 , B01D63/12 , B01D2313/105 , B01D2313/125 , B01D2313/21 , B01D2313/44 , B01D2315/10
Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.
Abstract translation: 公开了过滤液体进料的方法。 在一个版本中，该方法包括使液体进料通过单通道切向流过滤（SPTFF）系统，并且在分离的容器中从系统中回收渗余物和渗透物，而不通过SPTFF系统再循环。 在另一个版本中，过滤液体进料的方法包括使液体进料通过切向流过滤（TFF）系统，在分离的容器中从体系中回收渗透物和一部分滞留物，而不通过TFF系统再循环 剩余的残留物通过TFF系统至少一次。 该方法可以使用包括歧管段的SPTFF或TFF系统来执行，以串行化进料和滞留物的流动路径，而不需要转向板。
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公开(公告)号：US20150360180A1
公开(公告)日：2015-12-17
申请号：US14736646
申请日：2015-06-11
Applicant: EMD Millipore Corporation
Inventor： Herbert Lutz , Joseph Parrella
CPC classification number: B01D61/145 , B01D61/142 , B01D61/18 , B01D63/082 , B01D65/02 , B01D2313/18 , B01D2315/10 , B01D2319/022 , B01D2319/04 , B01D2321/04 , B01D2321/06 , B01D2321/164 , C07K1/34 , Y10T29/49828
Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.
Abstract translation: 本发明在各种实施例中提供了混合单通道切向流过滤组件，一次性单通道切向流过滤组件，可扩展单通道切向流过滤组件和可适应的模块化单通道切向流过滤组件。 在其它实施方案中，本发明涉及在单程切向流过滤组件中从过滤膜的表面回收蛋白质并用于清洗切向流过滤组件的方法。 在另外的实施例中，本发明提供了增加单通切向流过滤组件的处理能力的方法。
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