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31 条记录 (耗时 0.05 秒)

    PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISORDERS
    26.
    发明申请
    PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISORDERS 审中-公开
    用于治疗呼吸道感染和胃肠疾病的药物组合物

    公开(公告)号：US20100099651A1

    公开(公告)日：2010-04-22

    申请号：US12446794

    申请日：2007-10-23

    申请人： Birgit Jung ,  Frank Himmelsbach ,  Gerald Pohl

    发明人： Birgit Jung ,  Frank Himmelsbach ,  Gerald Pohl

    IPC分类号： A61K31/517 ,  A61K31/5377 ,  A61K31/56 ,  A61P11/00

    CPC分类号： A61K9/0073 ,  A61K31/517 ,  A61K31/5375 ,  A61K31/55 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to novel pharmaceutical compositions comprising at least one EGFR kinase inhibitor and at least one additional active compound selected from beta-2 mimetics, steroids, PDE-IV inhibitors, p38 MAP kinase inhibitors, NK1 antagonists, anticholinergics and endothelin antagonists, processes for preparing the compositions and the use thereof as medicament in the treatment of respiratory or gastrointestinal complaints, as well as inflammatory diseases of the joints, the skin or the eyes.

    摘要翻译： 本发明涉及包含至少一种EGFR激酶抑制剂和至少一种选自β-2模拟物，类固醇，PDE-IV抑制剂，p38 MAP激酶抑制剂，NK1拮抗剂，抗胆碱能药和内皮素拮抗剂的其它活性化合物的新型药物组合物， 用于制备组合物及其用作治疗呼吸道或胃肠道疾病以及关节，皮肤或眼睛的炎性疾病的药物。

    Anticholinergics, processes for preparing them and pharmaceutical composition containing them
    27.
    发明授权
    Anticholinergics, processes for preparing them and pharmaceutical composition containing them 有权
    抗胆碱能药，其制备方法和含有它们的药物组合物

    公开(公告)号：US07652138B2

    公开(公告)日：2010-01-26

    申请号：US10970240

    申请日：2004-10-21

    申请人： Helmut Meissner ,  Gerd Morschhaeuser ,  Michael Paul Pieper ,  Gerald Pohl ,  Richard Reichl ,  Georg Speck

    发明人： Helmut Meissner ,  Gerd Morschhaeuser ,  Michael Paul Pieper ,  Gerald Pohl ,  Richard Reichl ,  Georg Speck

    IPC分类号： C07D491/00 ,  C07D451/00

    CPC分类号： C07D451/10 ,  C07D451/14

    摘要： A compound of formula 1 wherein: A is a group selected from X− is an anion with a single negative charge; R1 and R2 are each independently a C1-C4-alkyl optionally substituted with hydroxy or halogen; and R3, R4, R5, R6, R7, and R8 are each independently hydrogen, C1-C4-alkyl, C1-C4-alkyloxy, hydroxy, CF3, CN, NO2, or halogen, with the proviso that at least one of the groups R3, R4, R5, R6, R7, and R8 is not hydrogen, processes for preparing these compounds, pharmaceutical compositions containing these compounds, and their use as pharmaceutical compositions.

    摘要翻译： 式1的化合物，其中：A是选自X - 是具有单个负电荷的阴离子; R 1和R 2各自独立地为任选被羟基或卤素取代的C 1 -C 4烷基; 并且R 3，R 4，R 5，R 6，R 7和R 8各自独立地为氢，C 1 -C 4 - 烷基，C 1 -C 4 - 烷氧基，羟基，CF 3，CN，NO 2或卤素，条件是至少一个 R 3，R 4，R 5，R 6，R 7和R 8不是氢，制备这些化合物的方法，含有这些化合物的药物组合物及其作为药物组合物的用途。

    Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
    29.
    发明授权
    Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions 有权
    呫吨羧酸盐，其制备方法及其作为药物组合物的用途

    公开(公告)号：US07405224B2

    公开(公告)日：2008-07-29

    申请号：US10342080

    申请日：2003-01-14

    申请人： Sabine Germeyer ,  Helmut Meissner ,  Gerd Morschhaeuser ,  Sabine Pestel ,  Michael P. Pieper ,  Gerald Pohl ,  Richard Reichl ,  Georg Speck

    发明人： Sabine Germeyer ,  Helmut Meissner ,  Gerd Morschhaeuser ,  Sabine Pestel ,  Michael P. Pieper ,  Gerald Pohl ,  Richard Reichl ,  Georg Speck

    IPC分类号： A61K31/44

    CPC分类号： C07D451/06 ,  C07D451/10

    摘要： Xanthenecarboxylates of formula 1 wherein: A is a group selected from X− is an anion with a single negative charge; R is hydroxy, methyl, hydroxymethyl, ethyl, —CF3, —CHF2, or fluorine; R1 and R2, which are identical or different, are each C1-C5-alkyl which is optionally substituted by C3-C6-cycloalkyl, hydroxy, or halogen, or R1 and R2 together denote a —C3-C5-alkylene-bridge; and R3, R4, R3′, and R4′, which are identical or different, are each hydrogen, —C1-C4-alkyl, —C4-alkyloxy, hydroxy, —CF3, —CHF2, —CN, —NO2, or halogen, or a physiologically acceptable salt thereof, processes for preparing, them and their use in pharmaceutical compositions.

    摘要翻译： 式1的呫吨羧酸盐其中：A是选自X - 的一个基团，是具有单个负电荷的阴离子; R是羟基，甲基，羟甲基，乙基，-CF 3，-CHF 2，或氟; R 1和R 2相同或不同，分别为C 1 -C 5 - 烷基，其中R 1和R 2各自为C 1 -C 5 - 任选被C 3 -C 6 - 环烷基，羟基或卤素取代，或R 1和R 2 - >一起表示-C 3 -C 5 - 亚烷基桥; 和R 3，R 4，R 3，R 3和R 4'相同或不同， 各自为氢，-C 1 -C 4 - 烷基，-C 4 - 烷氧基，羟基，-CF 3 - 或其生理学上可接受的盐，其制备方法，它们及其在药物组合物中的用途。