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公开(公告)号：US20060089403A1
公开(公告)日：2006-04-27
申请号：US11296162
申请日：2005-12-06
申请人： Georg Fertig , Frank Herting , Manfred Kubbies , Anja Limberg , Ulrike Reiff , Michael Weidner
发明人： Georg Fertig , Frank Herting , Manfred Kubbies , Anja Limberg , Ulrike Reiff , Michael Weidner
IPC分类号： C07D333/22 , A61K31/381
CPC分类号： C07D213/82 , C07C233/80 , C07C2601/02 , C07D333/38
摘要： Mono-acylated o-phenylendiamines derivatives of formula A: which are useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.
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公开(公告)号：US07208491B2
公开(公告)日：2007-04-24
申请号：US10771188
申请日：2004-02-03
申请人： Georg Fertig , Frank Herting , Manfred Kubbies , Anja Limberg , Ulrike Reiff , Michael Weidner
发明人： Georg Fertig , Frank Herting , Manfred Kubbies , Anja Limberg , Ulrike Reiff , Michael Weidner
IPC分类号： C07D333/56 , A61K31/5377 , A61K31/454 , A61K31/4439
CPC分类号： C07D333/70 , C07D209/42 , C07D307/85
摘要： Mono-acylated o-phenylendiamines derivatives of formula I wherein X and R are as described herein, have been found useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.
摘要翻译： 已经发现其中X和R如本文所述的式I的单酰化的邻苯基苯胺衍生物可用于治疗由组蛋白脱乙酰酶如癌症抑制介导的疾病。
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公开(公告)号：US07071219B2
公开(公告)日：2006-07-04
申请号：US10771184
申请日：2004-02-03
申请人： Georg Fertig , Frank Herting , Manfred Kubbies , Anja Limberg , Ulrike Reiff , Michael Weidner
发明人： Georg Fertig , Frank Herting , Manfred Kubbies , Anja Limberg , Ulrike Reiff , Michael Weidner
IPC分类号： A61K31/34 , C07D213/74
CPC分类号： C07D213/82 , C07C233/80 , C07C2601/02 , C07D333/38
摘要： Mono-acylated o-phenylendiamines derivatives of formula A wherein Ar, R1, and R2 are as described herein, have been found useful for the treatment of diseases mediated by the inhibition of histone deacetylase, such as cancer.
摘要翻译： 已经发现，其中Ar，R 1和R 2如本文所述的式A的单酰化的邻苯基苯胺衍生物可用于治疗由 抑制组蛋白脱乙酰酶，如癌症。
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24.发明申请BENZIMIDAZOLE AMIDO DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 失效苯扎咪唑胺衍生物及其制备和用作药物代理公开(公告)号：US20100168181A1
公开(公告)日：2010-07-01
申请号：US12600662
申请日：2008-06-23
申请人： Guy Georges , Eike Hoffmann , Klaus Kaluza , Matthias Koerner , Ulrike Reiff , Stefan Weigand
发明人： Guy Georges , Eike Hoffmann , Klaus Kaluza , Matthias Koerner , Ulrike Reiff , Stefan Weigand
IPC分类号： A61K31/4439 , C07D401/04
CPC分类号： C07D401/14 , C07D401/04
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备方法，以及上述用途， 提及的化合物在控制或预防诸如癌症的疾病中。
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公开(公告)号：US07956190B2
公开(公告)日：2011-06-07
申请号：US12600662
申请日：2008-06-23
申请人： Guy Georges , Eike Hoffmann , Klaus Kaluza , Matthias Koerner , Ulrike Reiff , Stefan Weigand
发明人： Guy Georges , Eike Hoffmann , Klaus Kaluza , Matthias Koerner , Ulrike Reiff , Stefan Weigand
IPC分类号： C07D401/00
CPC分类号： C07D401/14 , C07D401/04
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备方法，以及上述用途， 提及的化合物在控制或预防诸如癌症的疾病中。
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公开(公告)号：US20100041684A1
公开(公告)日：2010-02-18
申请号：US12444592
申请日：2007-12-19
申请人： Guy Georges , Matthias Koerner , Irene Kolm , Ulrike Reiff , Wolfgang Schaefer , Edgar Voss , Stefan Weigand
发明人： Guy Georges , Matthias Koerner , Irene Kolm , Ulrike Reiff , Wolfgang Schaefer , Edgar Voss , Stefan Weigand
IPC分类号： A61K31/505 , C07D239/47 , C07D239/56
CPC分类号： C07D239/47 , C07D405/12
摘要： Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）的化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在 控制或预防癌症等疾病。
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公开(公告)号：US08080552B2
公开(公告)日：2011-12-20
申请号：US12444592
申请日：2007-12-19
申请人： Guy Georges , Matthias Koerner , Irene Kolm , Ulrike Reiff , Wolfgang Schaefer , Edgar Voss , Stefan Weigand
发明人： Guy Georges , Matthias Koerner , Irene Kolm , Ulrike Reiff , Wolfgang Schaefer , Edgar Voss , Stefan Weigand
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04 , A61K31/505 , C07D239/02 , C07D239/00
CPC分类号： C07D239/47 , C07D405/12
摘要： Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）的化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在 控制或预防癌症等疾病。
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公开(公告)号：US20050209290A1
公开(公告)日：2005-09-22
申请号：US11083176
申请日：2005-03-17
IPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , A61K31/427 , A61K31/422 , C07D413/02 , C07D417/02
CPC分类号： C07D417/12 , C07D413/12 , C07D413/14
摘要： The present invention provides the compounds of formula (I) their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明提供式（I）化合物的药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的组合物及其制备方法，以及上述用途， 提及的化合物在控制或预防诸如癌症的疾病中。
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公开(公告)号：US20060235013A1
公开(公告)日：2006-10-19
申请号：US11384058
申请日：2006-03-17
申请人： Guy Georges , Bernhard Goller , Hans-Willi Krell , Anja Limberg , Ulrike Reiff , Petra Rueger , Matthias Rueth
发明人： Guy Georges , Bernhard Goller , Hans-Willi Krell , Anja Limberg , Ulrike Reiff , Petra Rueger , Matthias Rueth
IPC分类号： A61K31/5377 , A61K31/4745 , A61K31/4188 , C07D487/04
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明涉及式I化合物：其药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备，以及这些化合物的用途 控制或预防癌症等疾病。
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公开(公告)号：US20060063812A1
公开(公告)日：2006-03-23
申请号：US11230356
申请日：2005-09-20
申请人： Thomas Friess , Ulrike Reiff , Matthias Rueth , Edgar Voss
发明人： Thomas Friess , Ulrike Reiff , Matthias Rueth , Edgar Voss
IPC分类号： A61K31/427 , A61K31/422 , A61K31/4192 , C07D403/14 , C07D417/02
CPC分类号： C07D417/14 , C07D413/14
摘要： The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, compositions containing such compounds and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明涉及式I化合物：
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