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21.发明申请IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE 有权免疫调节寡核苷酸（IRO）化合物，以调节基于类似感受器的免疫应答公开(公告)号：US20090081198A1
公开(公告)日：2009-03-26
申请号：US12140338
申请日：2008-06-17
申请人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K39/395 , A61K31/7052 , A61K38/02 , A61P37/06 , A61K38/16 , A61K39/00
CPC分类号： A61K48/00 , A61K31/7052 , A61K2039/55561 , Y02A50/414
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
摘要翻译： 本发明提供作为TLR拮抗剂的新型免疫调节寡核苷酸（IRO）及其使用方法。 这些IRO具有独特的序列，其响应于TLR配体或TLR激动剂抑制或抑制TLR介导的信号传导。 该方法可用于预防和治疗癌症，自身免疫性疾病，气道炎症，炎症性疾病，感染性疾病，皮肤病，变态反应，哮喘或由病原体引起的疾病。
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公开(公告)号：US20090053206A1
公开(公告)日：2009-02-26
申请号：US12183439
申请日：2008-07-31
申请人： Ekambar R. Kandimalla , Mallikarjuna Putta , Daqing Wang , Dong Yu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Mallikarjuna Putta , Daqing Wang , Dong Yu , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K39/395 , C07H21/04 , A61K31/711 , A61K39/35 , A61K39/00
CPC分类号： A61K31/711 , A61K39/39
摘要： The invention relates to synthetic chemical compositions that are useful for modulation of Toll-Like Receptor (TLR)-mediated immune responses. In particular, the invention relates to agonists of Toll-Like Receptor 9 (TLR9) that generate unique cytokine and chemokine profiles.
摘要翻译： 本发明涉及可用于调节Toll样受体（TLR）介导的免疫应答的合成化学组合物。 特别地，本发明涉及产生独特细胞因子和趋化因子分布的Toll样受体9（TLR9）的激动剂。
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23.发明授权公开(公告)号：US08426375B2
公开(公告)日：2013-04-23
申请号：US12140334
申请日：2008-06-17
申请人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
CPC分类号： A61K48/00 , A61K31/7088 , A61K39/0008 , A61K2039/55561 , Y02A50/401
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
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24.发明申请公开(公告)号：US20090087388A1
公开(公告)日：2009-04-02
申请号：US12140334
申请日：2008-06-17
申请人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K9/12 , A61K31/7088 , A61K39/00 , A61K39/395 , A61K8/49 , A61K38/00 , A61K39/35
CPC分类号： A61K48/00 , A61K31/7088 , A61K39/0008 , A61K2039/55561 , Y02A50/401
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
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25.发明申请公开(公告)号：US20110009477A1
公开(公告)日：2011-01-13
申请号：US12832439
申请日：2010-07-08
申请人： Dong Yu , Lakshmi Bhagat , Daqing Wang , Ekambar Kandimalla , Sudhir Agrawal
发明人： Dong Yu , Lakshmi Bhagat , Daqing Wang , Ekambar Kandimalla , Sudhir Agrawal
IPC分类号： A61K31/7052 , C07H19/16 , A61P37/06
CPC分类号： A61K31/711 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0048 , A61K9/0056 , Y02A50/401 , Y02A50/411 , Y02A50/414
摘要： The invention provides novel oligonucleotide-based TLR antagonists containing a modified immune stimulatory motif and the use of such compounds in the prevention and treatment of TLR-medicated diseases. These oligonucleotide-based TLR antagonists containing a modified immune stimulatory motif have one or more chemical modifications in the immune stimulatory motif, which would be immune stimulatory but for the modification.
摘要翻译： 本发明提供了含有修饰的免疫刺激基序的新型基于寡核苷酸的TLR拮抗剂以及这些化合物在预防和治疗TLR药物疾病中的用途。 含有修饰的免疫刺激基序的这些基于寡核苷酸的TLR拮抗剂在免疫刺激基序中具有一种或多种化学修饰，其将是免疫刺激但是用于修饰。
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公开(公告)号：US08361986B2
公开(公告)日：2013-01-29
申请号：US13156140
申请日：2011-06-08
申请人： Ekambar R. Kandimalla , Mallikarjuna Putta , Daqing Wang , Dong Yu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar R. Kandimalla , Mallikarjuna Putta , Daqing Wang , Dong Yu , Lakshmi Bhagat , Sudhir Agrawal
CPC分类号： A61K31/711 , A61K39/39
摘要： The invention relates to synthetic chemical compositions that are useful for modulation of Toll-Like Receptor (TLR)-mediated immune responses. In particular, the invention relates to agonists of Toll-Like Receptor 9 (TLR9) that generate unique cytokine and chemokine profiles.
摘要翻译： 本发明涉及可用于调节Toll样受体（TLR）介导的免疫应答的合成化学组合物。 特别地，本发明涉及产生独特细胞因子和趋化因子分布的Toll样受体9（TLR9）的激动剂。
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公开(公告)号：US20090053205A1
公开(公告)日：2009-02-26
申请号：US12168641
申请日：2008-07-07
申请人： Ekambar Kandimalla , Tao Lan , Daqing Wang , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Tao Lan , Daqing Wang , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K39/395 , C07H21/02 , A61K31/7105 , A61K39/00
CPC分类号： A61K39/39 , A61K31/7105 , A61K2039/55561 , C07H21/02 , C12N15/117 , C12N2310/17 , C12N2310/317 , C12N2310/3183 , C12N2310/51 , C12N2320/51
摘要： The invention relates to the therapeutic use of novel stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides novel RNA-based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
摘要翻译： 本发明涉及新型稳定的寡核糖核苷酸作为免疫治疗应用的免疫调节剂的治疗用途。 具体地，本发明提供了具有改进的核酸酶和核糖核酸酶稳定性并且通过TLR7和/或TLR8具有免疫调节活性的新型的基于RNA的寡核糖核苷酸。
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公开(公告)号：US20120183530A1
公开(公告)日：2012-07-19
申请号：US13359714
申请日：2012-01-27
申请人： Ekambar Kandimalla , Tao Lan , Daqing Wang , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Tao Lan , Daqing Wang , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K39/395 , A61P37/02 , A61K39/00 , A61K47/00 , C07H21/02 , A61K31/7088
CPC分类号： A61K39/39 , A61K31/7105 , A61K2039/55561 , C07H21/02 , C12N15/117 , C12N2310/17 , C12N2310/317 , C12N2310/3183 , C12N2310/51 , C12N2320/51
摘要： The invention relates to the therapeutic use of novel stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides novel RNA-based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
摘要翻译： 本发明涉及新型稳定的寡核糖核苷酸作为免疫治疗应用的免疫调节剂的治疗用途。 具体地，本发明提供了具有改进的核酸酶和核糖核酸酶稳定性并且通过TLR7和/或TLR8具有免疫调节活性的新型的基于RNA的寡核糖核苷酸。
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公开(公告)号：US08188261B2
公开(公告)日：2012-05-29
申请号：US12168641
申请日：2008-07-07
申请人： Ekambar Kandimalla , Tao Lan , Daqing Wang , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Tao Lan , Daqing Wang , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： C07H21/04
CPC分类号： A61K39/39 , A61K31/7105 , A61K2039/55561 , C07H21/02 , C12N15/117 , C12N2310/17 , C12N2310/317 , C12N2310/3183 , C12N2310/51 , C12N2320/51
摘要： The invention relates to the therapeutic use of novel stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides novel RNA-based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
摘要翻译： 本发明涉及新型稳定的寡核糖核苷酸作为免疫治疗应用的免疫调节剂的治疗用途。 具体地，本发明提供了具有改进的核酸酶和核糖核酸酶稳定性并且通过TLR7和/或TLR8具有免疫调节活性的新型的基于RNA的寡核糖核苷酸。
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公开(公告)号：US20060019918A1
公开(公告)日：2006-01-26
申请号：US11173938
申请日：2005-07-01
申请人： Sudhir Agrawal , Lakshmi Bhagat , Dong Yu , Ekambar Kandimalla
发明人： Sudhir Agrawal , Lakshmi Bhagat , Dong Yu , Ekambar Kandimalla
CPC分类号： C12N15/117 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/111 , C12N2310/17 , C12N2310/33 , C12N2310/3519 , C12N2310/51
摘要： The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers and an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers and an immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunomers according to the invention further comprise at least two oligonucleotides linked at their 3′ ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunomodulatory oligonucleotide and having an accessible 5′ end.
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