公开(公告)号：US07471983B2

公开(公告)日：2008-12-30

申请号：US11185573

申请日：2005-07-19

申请人： John Michael Voegele ,  Clayton Scott Foster ,  David William Yost ,  Scott A. Meyer ,  Yanting Dong ,  Kevin John Stalsberg ,  Derek Daniel Bohn ,  Eric Keith Enrooth

发明人： John Michael Voegele ,  Clayton Scott Foster ,  David William Yost ,  Scott A. Meyer ,  Yanting Dong ,  Kevin John Stalsberg ,  Derek Daniel Bohn ,  Eric Keith Enrooth

IPC分类号： A61N1/365 ,  A61N1/08

CPC分类号： A61N1/3712

摘要： Adjusting the pacing energy involves performing a plurality of capture threshold tests, each capture threshold test measuring a capture threshold of the heart. One or more measured captured thresholds are selected, including at least one capture threshold that is higher relative to other measured capture thresholds acquired by the plurality of capture threshold tests. The pacing energy is adjusted based on the one or more selected capture thresholds.

摘要翻译： 调整起搏能量包括执行多个捕获阈值测试，每个捕获阈值测试测量心脏的捕获阈值。 选择一个或多个测量的捕获阈值，包括相对于通过多个捕获阈值测试获取的其他测量的捕获阈值更高的捕获阈值。 基于一个或多个选择的捕获阈值来调整起搏能量。

公开(公告)号：US20080275522A1

公开(公告)日：2008-11-06

申请号：US12217652

申请日：2008-07-07

申请人： Yanting Dong ,  Scott A. Meyer ,  Kevin John Stalsberg

发明人： Yanting Dong ,  Scott A. Meyer ,  Kevin John Stalsberg

IPC分类号： A61N1/37

CPC分类号： A61N1/371 ,  A61B5/04525

摘要： Cardiac devices and methods discriminate non-captured intrinsic beats during evoked response detection and classification by comparing the features of a post-pace cardiac signal with expected features associated with a non-captured response with intrinsic activation. Detection of a non-captured response with intrinsic activation may be based on the peak amplitude and timing of the cardiac signal. The methods may be used to discriminate between a fusion or capture beat and a non-captured intrinsic beat. Discriminating between possible cardiac responses to the pacing pulse may be useful, for example, during automatic capture verification and/or a capture threshold test.

摘要翻译： 心脏装置和方法通过将后期心脏信号的特征与与未捕获的应答相关联的预期特征与内在激活进行比较来区分诱发反应检测和分类期间的非捕获固有搏动。 利用内在激活的非捕获响应的检测可以基于心脏信号的峰值振幅和定时。 该方法可以用于区分融合或捕获节拍和未捕获的固有节拍。 对起搏脉冲的可能的心脏反应之间的区分可能是有用的，例如在自动捕获验证和/或捕获阈值测试期间。

公开(公告)号：US07337000B2

公开(公告)日：2008-02-26

申请号：US11116525

申请日：2005-04-28

申请人： Scott A. Meyer ,  Yanting Dong ,  Kevin John Stalsberg

发明人： Scott A. Meyer ,  Yanting Dong ,  Kevin John Stalsberg

IPC分类号： A61N1/362 ,  A61N1/365

CPC分类号： A61B5/0452 ,  A61B5/7264 ,  A61N1/362 ,  A61N1/371

摘要： Cardiac devices and methods involve the detection of cardiac signals features in adjacent classification intervals. Portions of the cardiac signal features detected in adjacent classification intervals are associated and are used to classify the cardiac response to a pacing pulse. Associating the portions of the cardiac signal features may be based on expected signal morphology.

摘要翻译： 心脏装置和方法涉及在相邻分类间隔中检测心脏信号特征。 在相邻分类间隔中检测到的心脏信号特征的部分相关联并且用于将心脏反应分类到起搏脉冲。 关联心脏信号特征的部分可以基于预期的信号形态。

公开(公告)号：US08457741B2

公开(公告)日：2013-06-04

申请号：US12906849

申请日：2010-10-18

申请人： Amy Jean Brisben ,  Aaron R. McCabe ,  Kevin John Stalsberg ,  Jacob I. Laughner ,  Clayton S. Foster ,  David W. Yost

发明人： Amy Jean Brisben ,  Aaron R. McCabe ,  Kevin John Stalsberg ,  Jacob I. Laughner ,  Clayton S. Foster ,  David W. Yost

IPC分类号： A61N1/368

CPC分类号： A61N1/371 ,  A61N1/3712 ,  A61N1/37282

摘要： Methods and devices are described that allow estimation of an electrostimulation capture threshold, such as a dedicated bipolar pacing vector threshold. In an example, an equal-energy assumption between first and second pacing vectors can be used to estimate an electrostimulation capture threshold of a second pacing vector from a measured electrostimulation capture threshold of the first pacing vector and impedances of the first and second pacing vectors. In an example, a relationship between first and second pacing vectors can be determined from measured data, and a parameter of the relationship can be used with a measurement of an electrostimulation capture threshold of the first pacing vector to estimate an electrostimulation capture threshold of the second pacing vector.

公开(公告)号：US08942819B2

公开(公告)日：2015-01-27

申请号：US13155549

申请日：2011-06-08

申请人： Juan Gabriel Hincapie Ordonez ,  Stephen Ruble ,  Jason J. Hamann ,  Eric A. Mokelke ,  Shantha Arcot-Krishnamurthy ,  Kevin John Stalsberg ,  David J. Ternes

发明人： Juan Gabriel Hincapie Ordonez ,  Stephen Ruble ,  Jason J. Hamann ,  Eric A. Mokelke ,  Shantha Arcot-Krishnamurthy ,  Kevin John Stalsberg ,  David J. Ternes

IPC分类号： A61N1/00 ,  A61N1/36

CPC分类号： A61N1/36142 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/36146

摘要： Various neural stimulator embodiments comprise controller circuitry, neural stimulation output circuitry, sensor circuitry and a memory. The neural stimulation output circuitry is configured to deliver the neural stimulation. The controller circuitry is configured to control stimulation parameters of the neural stimulation delivered by the neural stimulation output circuitry. The sensor circuitry, including at least one sensor, is configured to sense a response to the neural stimulation. The controller is configured to communicate with the sensor circuitry. The memory has instructions stored therein, operable on by the controller circuitry. The instructions include instructions for delivering neural stimulation using the neural stimulation output circuitry, instructions for controlling a titration sweep wherein the titration sweep varies stimulation parameter values, and instructions for monitoring a response to the titration sweep and automatically selecting stimulation parameters that provide an efficacious neural stimulation and provide a desirable safety margin to prevent injury to neural tissue.

摘要翻译： 各种神经刺激器实施例包括控制器电路，神经刺激输出电路，传感器电路和存储器。 神经刺激输出电路被配置为递送神经刺激。 控制器电路被配置为控制由神经刺激输出电路传递的神经刺激的刺激参数。 包括至少一个传感器的传感器电路被配置为感测对神经刺激的响应。 控制器被配置为与传感器电路通信。 存储器具有存储在其中的指令，由控制器电路可操作。 说明书包括使用神经刺激输出电路递送神经刺激的指令，用于控制滴定扫描的指令，其中滴定扫描改变刺激参数值，以及用于监测对滴定扫描的响应的指令，并自动选择提供有效神经元的刺激参数 刺激并提供理想的安全余量以防止对神经组织的损伤。

公开(公告)号：US08521285B2

公开(公告)日：2013-08-27

申请号：US12906855

申请日：2010-10-18

申请人： Amy Jean Brisben ,  Aaron R. McCabe ,  Clayton S. Foster ,  David W. Yost ,  Kevin John Stalsberg ,  Jacob I. Laughner

发明人： Amy Jean Brisben ,  Aaron R. McCabe ,  Clayton S. Foster ,  David W. Yost ,  Kevin John Stalsberg ,  Jacob I. Laughner

IPC分类号： A61N1/36

CPC分类号： A61N1/3712 ,  A61N1/3627

摘要： Methods and devices are described that allow estimation of an electrostimulation capture threshold, such as a dedicated bipolar pacing vector threshold. In an example, an equal-energy assumption between first and second pacing vectors can be used to estimate an electrostimulation capture threshold of a second pacing vector from a measured electrostimulation capture threshold of the first pacing vector and impedances of the first and second pacing vectors. In an example, a relationship between first and second pacing vectors can be determined from measured data, and a parameter of the relationship can be used with a measurement of an electrostimulation capture threshold of the first pacing vector to estimate an electrostimulation capture threshold of the second pacing vector.

摘要翻译： 描述了允许估计电刺激捕获阈值（例如专用双极起搏矢量阈值）的方法和装置。 在一个示例中，可以使用第一和第二起搏向量之间的等能量假设从第一起搏向量的测量的电刺激捕获阈值和第一和第二起搏向量的阻抗来估计第二起搏向量的电刺激捕获阈值。 在一个示例中，可以从测量数据确定第一和第二起搏向量之间的关系，并且可以使用关系的参数与第一起搏向量的电刺激捕获阈值的测量来估计第二起搏向量的电刺激捕获阈值 起搏向量

公开(公告)号：US20110098774A1

公开(公告)日：2011-04-28

申请号：US12906855

申请日：2010-10-18

申请人： Amy Jean Brisben ,  Aaron R. McCabe ,  Clayton S. Foster ,  David W. Yost ,  Kevin John Stalsberg ,  Jacob I. Laughner

发明人： Amy Jean Brisben ,  Aaron R. McCabe ,  Clayton S. Foster ,  David W. Yost ,  Kevin John Stalsberg ,  Jacob I. Laughner

IPC分类号： A61N1/08

CPC分类号： A61N1/3712 ,  A61N1/3627

摘要： Methods and devices are described that allow estimation of an electrostimulation capture threshold, such as a dedicated bipolar pacing vector threshold. In an example, an equal-energy assumption between first and second pacing vectors can be used to estimate an electrostimulation capture threshold of a second pacing vector from a measured electrostimulation capture threshold of the first pacing vector and impedances of the first and second pacing vectors. In an example, a relationship between first and second pacing vectors can be determined from measured data, and a parameter of the relationship can be used with a measurement of an electrostimulation capture threshold of the first pacing vector to estimate an electrostimulation capture threshold of the second pacing vector.

公开(公告)号：US08456309B2

公开(公告)日：2013-06-04

申请号：US13539802

申请日：2012-07-02

申请人： Haresh G. Sachanandani ,  Jon Peterson ,  Shelley M. Cazares ,  Robert J. Sweeney ,  Kevin John Stalsberg

发明人： Haresh G. Sachanandani ,  Jon Peterson ,  Shelley M. Cazares ,  Robert J. Sweeney ,  Kevin John Stalsberg

IPC分类号： G08B21/00

CPC分类号： A61B5/0031 ,  A61B5/0205 ,  A61B5/02455 ,  A61B5/0402 ,  A61B5/076 ,  A61B5/0816 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/7275 ,  A61B5/746 ,  A61B2560/0242 ,  A61N1/3627 ,  A61N1/37252 ,  G06F19/00

摘要： This document discusses, among other things, systems and methods for predicting heart failure decompensation using within-patient diagnostics. A method comprises detecting an alert status of each of one or more sensors; calculating an alert score by combining the detected alerts; and calculating a composite alert score, the composite alert score being indicative of a physiological condition and comprising a combination of two or more alert scores.

公开(公告)号：US08223023B2

公开(公告)日：2012-07-17

申请号：US13229110

申请日：2011-09-09

申请人： Haresh G. Sachanandani ,  Jon Peterson ,  Shelley M. Cazares ,  Robert J. Sweeney ,  Kevin John Stalsberg

发明人： Haresh G. Sachanandani ,  Jon Peterson ,  Shelley M. Cazares ,  Robert J. Sweeney ,  Kevin John Stalsberg

IPC分类号： G08B21/00

CPC分类号： A61B5/0031 ,  A61B5/0205 ,  A61B5/02455 ,  A61B5/0402 ,  A61B5/076 ,  A61B5/0816 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/7275 ,  A61B5/746 ,  A61B2560/0242 ,  A61N1/3627 ,  A61N1/37252 ,  G06F19/00

摘要： This document discusses, among other things, systems and methods for predicting heart failure decompensation using within-patient diagnostics. A method comprises detecting an alert status of each of one or more sensors; calculating an alert score by combining the detected alerts; and calculating a composite alert score, the composite alert score being indicative of a physiological condition and comprising a combination of two or more alert scores.

摘要翻译： 本文件还讨论了使用病人诊断预测心力衰竭失代偿失调的系统和方法。 一种方法包括检测一个或多个传感器中的每一个的警报状态; 通过组合检测到的警报来计算警报评分; 以及计算复合警报评分，所述复合警报评分指示生理状况并且包括两个或更多个警报得分的组合。

公开(公告)号：US20110313488A1

公开(公告)日：2011-12-22

申请号：US13155549

申请日：2011-06-08

申请人： Juan Gabriel Hincapie Ordonez ,  Stephen Ruble ,  Jason J. Hamann ,  Eric A. Mokelke ,  Shantha Arcot-Krishnamurthy ,  Kevin John Stalsberg ,  David J. Ternes

发明人： Juan Gabriel Hincapie Ordonez ,  Stephen Ruble ,  Jason J. Hamann ,  Eric A. Mokelke ,  Shantha Arcot-Krishnamurthy ,  Kevin John Stalsberg ,  David J. Ternes

IPC分类号： A61N1/36

CPC分类号： A61N1/36142 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/36146

摘要： Various neural stimulator embodiments comprise controller circuitry, neural stimulation output circuitry, sensor circuitry and a memory. The neural stimulation output circuitry is configured to deliver the neural stimulation. The controller circuitry is configured to control stimulation parameters of the neural stimulation delivered by the neural stimulation output circuitry. The sensor circuitry, including at least one sensor, is configured to sense a response to the neural stimulation. The controller is configured to communicate with the sensor circuitry. The memory has instructions stored therein, operable on by the controller circuitry. The instructions include instructions for delivering neural stimulation using the neural stimulation output circuitry, instructions for controlling a titration sweep wherein the titration sweep varies stimulation parameter values, and instructions for monitoring a response to the titration sweep and automatically selecting stimulation parameters that provide an efficacious neural stimulation and provide a desirable safety margin to prevent injury to neural tissue.

摘要翻译： 各种神经刺激器实施例包括控制器电路，神经刺激输出电路，传感器电路和存储器。 神经刺激输出电路被配置为递送神经刺激。 控制器电路被配置为控制由神经刺激输出电路传递的神经刺激的刺激参数。 包括至少一个传感器的传感器电路被配置为感测对神经刺激的响应。 控制器被配置为与传感器电路通信。 存储器具有存储在其中的指令，可由控制器电路操作。 说明书包括使用神经刺激输出电路递送神经刺激的指令，用于控制滴定扫描的指令，其中滴定扫描改变刺激参数值，以及用于监测对滴定扫描的响应的指令，并自动选择提供有效神经元的刺激参数 刺激并提供理想的安全余量以防止对神经组织的损伤。