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公开(公告)号：US08483821B2
公开(公告)日：2013-07-09
申请号：US12843444
申请日：2010-07-26
CPC分类号： A61N1/3601 , A61B5/0537 , A61B5/0538 , A61B5/0809 , A61B5/4035 , A61B5/4869 , A61N1/36114 , A61N1/36521 , A61N1/36585
摘要： A first fluid status indicator of a pulmonary fluid status associated with pulmonary edema and a second fluid status indicator of a non-pulmonary fluid status can be used to provide an alert or to control a therapy for pulmonary edema. Additionally, intermittent cardiac blood volume redistribution therapy can be used to provide cardiac conditioning in heart failure patients.
摘要翻译： 可以使用与肺水肿相关的肺液体状态和非肺液体状态的第二流体状态指示器的第一流体状态指示器来提供警报或控制肺水肿的治疗。 此外，间歇性心脏血容量再分配治疗可用于在心力衰竭患者中提供心脏调节。
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公开(公告)号：US08285373B2
公开(公告)日：2012-10-09
申请号：US12835288
申请日：2010-07-13
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61B5/0255 , A61B5/0816 , A61B5/0823 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61B2562/043 , A61N1/36053 , A61N1/36114 , A61N1/36117 , A61N1/36578
摘要： An embodiment uses an accelerometer to sense heart sounds, and determines heart rate info nation using the sensed heart sounds. An embodiment uses an accelerometer to sense respiratory activity. An embodiment delivers a programmed neural stimulation therapy with a programmed duty cycle, where the programmed duty cycle includes a stimulation ON portion followed by a stimulation OFF portion. An electrode electrically connected to the implanted neural stimulation device is used to remotely detect cardiac activity. The remotely detected cardiac activity is used to detect heart rate information during the stimulation ON portion and to detect heart rate information during the stimulation OFF portion. The detected heart rate information and/or the detected respiration information are used to control a neural stimulation therapy performed by the neural stimulator device and/or are used to provide diagnostic information for the patient's condition.
摘要翻译： 一个实施例使用加速度计来感测心脏声音，并且使用所感测到的心脏声音来确定心率信息国家。 一个实施例使用加速计来感测呼吸活动。 实施例以编程的占空比递送编程的神经刺激疗法，其中编程的占空比包括刺激开启部分，随后是刺激关闭部分。 电连接到植入的神经刺激装置的电极用于远程检测心脏活动。 远程检测到的心脏活动用于在刺激ON部分期间检测心率信息，并在刺激OFF部分期间检测心率信息。 检测到的心率信息和/或检测到的呼吸信息用于控制由神经刺激器装置执行的神经刺激治疗和/或用于提供患者状况的诊断信息。
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公开(公告)号：US20120065702A1
公开(公告)日：2012-03-15
申请号：US13220423
申请日：2011-08-29
申请人： Shantha Arcot-Krishnamurthy , David J. Ternes , Jason Hamann , Juan Gabriel Hincapie Ordonez , Stephen Ruble
发明人： Shantha Arcot-Krishnamurthy , David J. Ternes , Jason Hamann , Juan Gabriel Hincapie Ordonez , Stephen Ruble
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36128 , A61N1/36146 , A61N1/36185 , A61N1/37235 , A61N1/37288
摘要： A neurostimulation system includes a neural stimulation lead having a proximal portion and a distal portion and including a plurality of electrodes along the distal portion. The plurality of electrodes are configured for positioning proximate a portion of the autonomic nervous system. A neural stimulation circuit, coupled to the plurality of electrodes, delivers neural stimulation pulses to the plurality of electrodes. A processor and controller is configured to control the neural stimulation circuit to deliver first neural stimulation pulses to each of a plurality of electrode configurations. Each electrode configuration includes one or more of the plurality of electrodes. The processor and controller is further configured to receive information related to motor fiber activity that is induced in response to delivery of the first neural stimulation pulses to each of the plurality of electrode configurations and to identify the electrode configurations that induce the motor fiber activity.
摘要翻译： 神经刺激系统包括神经刺激引线，其具有近端部分和远端部分，并且沿着远端部分包括多个电极。 多个电极被配置用于定位在自主神经系统的一部分附近。 耦合到多个电极的神经刺激电路将神经刺激脉冲传送到多个电极。 处理器和控制器被配置为控制神经刺激电路将第一神经刺激脉冲传送到多个电极配置中的每一个。 每个电极配置包括多个电极中的一个或多个。 所述处理器和控制器进一步被配置为接收与响应于所述第一神经刺激脉冲传送到所述多个电极配置中的每一个而被诱发的电动机纤维活动相关的信息，并且识别诱导所述电机纤维活性的电极配置。
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公开(公告)号：US20110137360A1
公开(公告)日：2011-06-09
申请号：US12962168
申请日：2010-12-07
IPC分类号： A61N1/36
CPC分类号： A61N1/36146 , A61B5/0028 , A61B5/4848 , A61B5/7207 , A61N1/37 , A61N1/37288
摘要： Various method embodiments detect a concurrent therapy, where the concurrent therapy includes a plurality of therapy pulses. Detecting the concurrent therapy includes detecting at least one electrical pulse, extracting at least one characteristic from the at least one electrical pulse, comparing the at least one characteristic of the detected pulse to at least one characteristic of therapy pulses, and detecting that the concurrent therapy is being applied if the at least one characteristic of the detected pulse favorably compares to the at least one characteristic of the therapy pulses.
摘要翻译： 各种方法实施例检测并行治疗，其中并发治疗包括多个治疗脉冲。 检测并行治疗包括检测至少一个电脉冲，从至少一个电脉冲中提取至少一个特征，将检测到的脉冲的至少一个特征与治疗脉冲的至少一个特征进行比较，以及检测并发治疗 如果检测到的脉冲的至少一个特性有利地与治疗脉冲的至少一个特性相比较，则被应用。
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公开(公告)号：US20110093026A1
公开(公告)日：2011-04-21
申请号：US12892694
申请日：2010-09-28
申请人： Ramesh Wariar , Jeffrey E. Stahmann , Roger Hastings , Stephen Ruble , Ronald W. Heil , Stephen J. Hahn , Arjun Sharma
发明人： Ramesh Wariar , Jeffrey E. Stahmann , Roger Hastings , Stephen Ruble , Ronald W. Heil , Stephen J. Hahn , Arjun Sharma
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36007 , A61N1/36114 , A61N1/36135 , A61N1/37288
摘要： An implantable cardiorenal stimulator delivers cardiorenal stimulation in response to detection of decompensation associated with heart failure. The cardiorenal stimulation includes delivering renal stimulation pulses to promote diuresis and/or natriuresis and delivering cardiac stimulation pulses to enhance the diuretic and/or natriuretic effects of the renal stimulation pulses.
摘要翻译： 可植入的心肾刺激器响应于与心力衰竭相关的代偿失调的检测而提供心脏刺激。 心脏刺激包括递送肾刺激脉冲以促进利尿和/或利尿，并递送心脏刺激脉冲以增强肾刺激脉冲的利尿和/或利尿钠效应。
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公开(公告)号：US20110015702A1
公开(公告)日：2011-01-20
申请号：US12835288
申请日：2010-07-13
CPC分类号： A61N1/36139 , A61B5/0255 , A61B5/0816 , A61B5/0823 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61B2562/043 , A61N1/36053 , A61N1/36114 , A61N1/36117 , A61N1/36578
摘要： An embodiment uses an accelerometer to sense heart sounds, and determines heart rate info nation using the sensed heart sounds. An embodiment uses an accelerometer to sense respiratory activity. An embodiment delivers a programmed neural stimulation therapy with a programmed duty cycle, where the programmed duty cycle includes a stimulation ON portion followed by a stimulation OFF portion. An electrode electrically connected to the implanted neural stimulation device is used to remotely detect cardiac activity. The remotely detected cardiac activity is used to detect heart rate information during the stimulation ON portion and to detect heart rate information during the stimulation OFF portion. The detected heart rate information and/or the detected respiration information are used to control a neural stimulation therapy performed by the neural stimulator device and/or are used to provide diagnostic information for the patient's condition.
摘要翻译： 一个实施例使用加速度计来感测心脏声音，并且使用所感测到的心脏声音来确定心率信息国家。 一个实施例使用加速计来感测呼吸活动。 实施例以编程的占空比递送编程的神经刺激疗法，其中编程的占空比包括刺激开启部分，随后是刺激关闭部分。 电连接到植入的神经刺激装置的电极用于远程检测心脏活动。 远程检测到的心脏活动用于在刺激ON部分期间检测心率信息，并在刺激OFF部分期间检测心率信息。 检测到的心率信息和/或检测到的呼吸信息用于控制由神经刺激器装置执行的神经刺激治疗和/或用于提供患者状况的诊断信息。
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公开(公告)号：US08588906B2
公开(公告)日：2013-11-19
申请号：US12835325
申请日：2010-07-13
IPC分类号： A61N1/08
CPC分类号： A61N1/36585 , A61B5/024 , A61B5/02405 , A61B5/0452 , A61B5/0456 , A61B5/0464 , A61B7/00 , A61B7/003 , A61B2562/0219 , A61N1/3601 , A61N1/36114 , A61N1/36117 , A61N1/36578
摘要： An embodiment of an implantable system configured to be implanted in a patient includes an accelerometer, a neural stimulator, and a controller. The neural stimulator is configured to deliver neural stimulation to a neural target. The controller is configured to use the accelerometer to detect laryngeal vibration or coughing, and is configured to deliver a programmed neural stimulation therapy using the neural stimulator and using detected laryngeal vibration or detected coughing as an input to the programmed neural stimulation therapy.
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8.发明申请METHOD AND APPARATUS FOR CONTROLLING NEUROSTIMULATION ACCORDING TO PHYSICAL STATE 审中-公开用于根据物理状态控制神经元的方法和装置公开(公告)号：US20130226264A1
公开(公告)日：2013-08-29
申请号：US13858405
申请日：2013-04-08
申请人： Abhi V. Chavan , Keith R. Maile , David J. Ternes , Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann
发明人： Abhi V. Chavan , Keith R. Maile , David J. Ternes , Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36135
摘要： A neurostimulation system senses a signal indicative of a patient's physical state such as posture and/or activity level. In various embodiments, a stored value for each of stimulation parameters controlling delivery of neurostimulation is selected according to the patient's physical state. In various embodiments, values of the stimulation parameters are approximately optimized for each of a number of different physical states, and are stored for later selection.
摘要翻译： 神经刺激系统感测指示患者的身体状态（例如姿势和/或活动水平）的信号。 在各种实施例中，根据患者的身体状态选择控制神经刺激传递的每个刺激参数的存储值。 在各种实施例中，刺激参数的值针对多个不同物理状态中的每一个近似优化，并且被存储以供稍后选择。
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9.发明申请METHOD AND APPARATUS FOR ADAPTIVE CONTROL OF NEUROSTIMULATION USING CARDIAC RESTITUTION 有权使用心脏衰竭治疗神经病学自适应控制的方法和装置公开(公告)号：US20130053914A1
公开(公告)日：2013-02-28
申请号：US13586503
申请日：2012-08-15
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/36139
摘要： A neurostimulation system measures a cardiac parameter at various cardiac intervals and analyzes its restitution, including computing a restitution slope being a rate of change of the restitution parameter with respect to change in the cardiac interval. In various embodiments, the system uses the restitution slope to provide for adaptive control of neurostimulation. In various embodiments, one or more cardiac parameters such as action potential duration (APD), conduction velocity (CV), QT interval (QT), and/or T-wave morphology (TM) parameter are measured and analyzed for restitution of each parameter, which is then used to control the delivery of the neurostimulation.
摘要翻译： 神经刺激系统以各种心脏间隔测量心脏参数并分析其恢复，包括计算相对于心脏间隔变化的恢复参数的变化率的恢复斜率。 在各种实施例中，系统使用恢复斜率来提供神经刺激的自适应控制。 在各种实施例中，测量并分析一个或多个心脏参数，例如动作电位持续时间（APD），传导速度（CV），QT间期（QT）和/或T波形态（TM）参数，以分析每个参数的恢复 ，然后用于控制神经刺激的递送。
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公开(公告)号：US20110313488A1
公开(公告)日：2011-12-22
申请号：US13155549
申请日：2011-06-08
申请人： Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann , Eric A. Mokelke , Shantha Arcot-Krishnamurthy , Kevin John Stalsberg , David J. Ternes
发明人： Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann , Eric A. Mokelke , Shantha Arcot-Krishnamurthy , Kevin John Stalsberg , David J. Ternes
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36114 , A61N1/36139 , A61N1/36146
摘要： Various neural stimulator embodiments comprise controller circuitry, neural stimulation output circuitry, sensor circuitry and a memory. The neural stimulation output circuitry is configured to deliver the neural stimulation. The controller circuitry is configured to control stimulation parameters of the neural stimulation delivered by the neural stimulation output circuitry. The sensor circuitry, including at least one sensor, is configured to sense a response to the neural stimulation. The controller is configured to communicate with the sensor circuitry. The memory has instructions stored therein, operable on by the controller circuitry. The instructions include instructions for delivering neural stimulation using the neural stimulation output circuitry, instructions for controlling a titration sweep wherein the titration sweep varies stimulation parameter values, and instructions for monitoring a response to the titration sweep and automatically selecting stimulation parameters that provide an efficacious neural stimulation and provide a desirable safety margin to prevent injury to neural tissue.
摘要翻译： 各种神经刺激器实施例包括控制器电路，神经刺激输出电路，传感器电路和存储器。 神经刺激输出电路被配置为递送神经刺激。 控制器电路被配置为控制由神经刺激输出电路传递的神经刺激的刺激参数。 包括至少一个传感器的传感器电路被配置为感测对神经刺激的响应。 控制器被配置为与传感器电路通信。 存储器具有存储在其中的指令，可由控制器电路操作。 说明书包括使用神经刺激输出电路递送神经刺激的指令，用于控制滴定扫描的指令，其中滴定扫描改变刺激参数值，以及用于监测对滴定扫描的响应的指令，并自动选择提供有效神经元的刺激参数 刺激并提供理想的安全余量以防止对神经组织的损伤。
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