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公开(公告)号：US10258603B2
公开(公告)日：2019-04-16
申请号：US15592012
申请日：2017-05-10
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , F. Anthony Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC: A61K31/40 , C07D471/04 , C07D519/00
Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, Rc, and Rd have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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公开(公告)号：US10202354B2
公开(公告)日：2019-02-12
申请号：US15643805
申请日：2017-07-07
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Alexandre Cote , Victor Gehling , Vickie Hsiao-Wei Tsui , James Richard Jr. Kiefer , Jun Liang , Steven Magnuson , Christopher G. Nasveschuk , F. Anthony Romero , Alexander M. Taylor
IPC: C07D233/44 , C07D235/02 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/08
Abstract: The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM2b. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US10150767B2
公开(公告)日：2018-12-11
申请号：US15592017
申请日：2017-05-10
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Steven F. Bellon , Daniel J. Burdick , Alexandre Cote , Terry Crawford , Les A. Dakin , Vickie Hsiao-Wei Tsui , Michael Charles Hewitt , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , Anthony F. Romero , Yong Tang , Alexander M. Taylor , Shumei Wang
IPC: C07D471/04 , A61K31/437 , C07D519/00 , A61K31/4985 , A61K31/496 , A61K31/4545 , A61K45/06
Abstract: The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.
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公开(公告)号：US20180022707A1
公开(公告)日：2018-01-25
申请号：US15643805
申请日：2017-07-07
Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , Alexandre Cote , Victor Gehling , Vickie Hsiao-Wei Tsui , James Richard Jr. Kiefer , Jun Liang , Steven Magnuson , Christopher G. Nasveschuk , F. Anthony Romero , Alexander M. Taylor
IPC: C07D233/44 , C07D487/08 , C07D413/12 , C07D417/12 , C07D403/12 , C07D409/12
CPC classification number: C07D233/44 , C07D235/02 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/08
Abstract: The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM2b. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US09469646B2
公开(公告)日：2016-10-18
申请号：US14839273
申请日：2015-08-28
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Les A. Dakin , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D401/12 , C07D401/14 , C07D487/04 , C07D417/04 , C07D417/14 , C07D405/14 , C07D409/06 , C07D471/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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Patent Agency Ranking
26.发明申请公开(公告)号：US20150376190A1
公开(公告)日：2015-12-31
申请号：US14766632
申请日：2014-02-11
Applicant: CONSTELLATION PHARMACEUTICALS, INC.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew S. Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D487/04 , C07D471/04
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents having the structural Formula (II) for modulating histone methyl modifying enzymes, compositions and uses thereof for instance as anti-cancer agents are provided herein.
Abstract translation: 具有用于调节组蛋白甲基修饰酶的结构式（II）的试剂，其组合物和用途，例如作为抗癌剂。
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公开(公告)号：US09980952B2
公开(公告)日：2018-05-29
申请号：US15155749
申请日：2016-05-16
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: C07D471/04 , A61K31/4545 , C07D401/14 , C07D401/12 , C07D417/04 , C07D487/04 , C07D417/14 , C07D405/14 , C07D409/06
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US20140315949A1
公开(公告)日：2014-10-23
申请号：US14358455
申请日：2012-11-19
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Alexandre Gagnon , Jean-Christophe Harmange , Christopher G. Nasveschuk
IPC: C07D213/64 , C07D401/12 , C07D405/12
CPC classification number: C07D213/64 , C07D213/81 , C07D401/12 , C07D405/12
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
Abstract translation: 本文提供了用于调节甲基修饰酶的组合物及其用途。
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公开(公告)号：US20140288123A1
公开(公告)日：2014-09-25
申请号：US14358558
申请日：2012-11-19
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Alexandre Gagnon , Jean-Christophe Harmange , Christopher G. Nasveschuk
IPC: C07D213/64
CPC classification number: C07D213/64 , C07D221/18 , C07D401/12 , C07D405/12 , C07D413/12
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US20170056388A1
公开(公告)日：2017-03-02
申请号：US15257275
申请日：2016-09-06
Applicant: Constellation Pharmaceuticals, Inc.
Inventor： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC: A61K31/4545
CPC classification number: A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
Abstract translation: 本文提供了用于调节甲基修饰酶的组合物及其用途。
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