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公开(公告)号：US20180194845A1
公开(公告)日：2018-07-12
申请号：US15832366
申请日：2017-12-05
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Simone DE HAIJ , Thilo RIEDL , Rene HOET , Ole BAADSGAARD , Jan VAN DE WINKEL , David SATIJN , Paul PARREN , Aran Frank LABRIJN , Joyce MEESTERS , Janine SCHUURMAN , Edward N. VAN DEN BRINK
CPC classification number: C07K16/2863 , A61K2039/505 , C07K16/2809 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/528 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US20180179286A1
公开(公告)日：2018-06-28
申请号：US15832421
申请日：2017-12-05
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Simone DE HAIJ , Thilo RIEDL , Rene HOET , Ole BAADSGAARD , Jan VAN DE WINKEL , David SATIJN , Paul PARREN , Aran Frank LABRIJN , Joyce MEESTERS , Janine SCHUURMAN , Edward N. VAN DEN BRINK
CPC classification number: C07K16/2863 , A61K2039/505 , C07K16/2809 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/528 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US20170369590A1
公开(公告)日：2017-12-28
申请号：US15599393
申请日：2017-05-18
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Patrick VAN BERKEL , Kristin STRUMANE , Aran Frank LABRIJN , Joost J. NEIJSSEN , Joyce I. MEESTERS , Paul PARREN , Janine SCHUURMAN
IPC: C07K16/32 , A61K45/06 , A61K47/68 , A61K39/395 , A61K39/00
CPC classification number: C07K16/32 , A61K39/395 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K47/6855 , A61K47/6879 , A61K2039/505 , C07K16/1063 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/31 , C07K2317/33 , C07K2317/41 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2317/94
Abstract: Bispecific antibodies which comprise antigen-binding regions binding to two different epitopes of human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods of preparing and using the antibodies are also disclosed.
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公开(公告)号：US20170355767A1
公开(公告)日：2017-12-14
申请号：US15541594
申请日：2016-01-08
Applicant: GENMAB A/S
Inventor： Patrick ENGELBERTS , Esther BREIJ , Rik RADEMAKER , Isil ALTINTAS , David SATIJN , Sandra VERPLOEGEN , Riemke VAN DIJKHUIZEN RADERSMA , Edward VAN DEN BRINK , Janine SCHUURMAN , Paul PARREN
IPC: C07K16/28 , A61K39/395
CPC classification number: C07K16/2809 , A61K39/39558 , A61K2039/505 , C07K16/2887 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/90 , C07K2317/92 , C07K2317/94
Abstract: Bispecific antibodies directed to CD3 and CD20 and uses of such bispecific antibodies, in particular use thereof in the treatment of diseases in which specific targeting and T cell-mediated killing of cells that express CD20 is desired.
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25.发明申请HETERODIMERIC ANTIBODY FC-CONTAINING PROTEINS AND METHODS FOR PRODUCTION THEREOF 审中-公开含杂交抗体的含FC蛋白质及其生产方法公开(公告)号：US20160046727A1
公开(公告)日：2016-02-18
申请号：US14830336
申请日：2015-08-19
Applicant: GENMAB A/S
Inventor： Aran Frank LABRIJN , Joyce I. MEESTERS , Ewald T. J. VAN DEN BREMER , Joost J. NEIJSSEN , Patrick VAN BERKEL , Bart DE GOEIJ , Tom VINK , Jan VAN DE WINKEL , Janine SCHUURMAN , Paul PARREN
CPC classification number: C07K16/468 , A61K2039/505 , C07K16/1063 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/6854
Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins
Abstract translation: 新型异二聚抗体-Fc的蛋白质，例如双特异性抗体，以及用于产生这种蛋白质的新方法
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Patent Agency Ranking
公开(公告)号：US20240254252A1
公开(公告)日：2024-08-01
申请号：US17259342
申请日：2019-07-15
Applicant: GENMAB A/S
Inventor： Bart E. C. G. DE GOEIJ , Grietje ANDRINGA , Frank BEURSKENS , Janine SCHUURMAN , David SATIJN , Tahamtan AHMADI
CPC classification number: C07K16/2896 , A61P35/02 , A61K2039/505 , C07K2317/52 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76
Abstract: Antibody variants for therapeutic use involving trogocytosis-mediated reduction of CD38 on CD38-expressing immunosuppressive cells; particularly CD38 antibody variants comprising one or more mutations in the Fc region, such a mutation in one or more amino acid residues corresponding to E430, E345 and S440 in a human IgG1 heavy chain, wherein the amino 5 acid residues are numbered according to the EU index.
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公开(公告)号：US20240150484A1
公开(公告)日：2024-05-09
申请号：US18281372
申请日：2022-03-11
Applicant: GENMAB A/S
Inventor： Bart-Jan DE KREUK , Richard HIBBERT , Janine SCHUURMAN , Aran F. LABRIJN
CPC classification number: C07K16/2887 , C07K1/1075 , C07K16/18 , C07K16/2809 , C07K16/2833 , C07K16/32 , C07K2317/31 , C07K2317/54 , C07K2317/92 , C07K2317/94
Abstract: Described herein are proteins comprising an Fc region or the like, such as monoclonal, bispecific and multispecific antibodies, wherein the Fc region has been modified to eliminate or strongly reduce Fc-mediated effector functions, while at the same time allow for good developability, for therapeutic purposes and where such effector functions are undesired.
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公开(公告)号：US20230310599A1
公开(公告)日：2023-10-05
申请号：US18023808
申请日：2021-09-02
Applicant: GENMAB A/S
Inventor： Hreinn BENONISSON , Jim MIDDELBURG , Thorbald VAN HALL , Isil ALTINTAS , Kristel KEMPER , Janine SCHUURMAN , Katy Ann LLOYD , Vitalijs OVCINNIKOVS , Gijsbertus ZOM
CPC classification number: A61K39/42 , A61P35/00 , A61P37/04 , A61K2039/545
Abstract: The present invention relates to combination therapy within the field of oncology; in particular to combination therapy with vaccines and binding agents binding to CD3 and to a target antigen on tumor cells.
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公开(公告)号：US20220389101A1
公开(公告)日：2022-12-08
申请号：US17739940
申请日：2022-05-09
Applicant: GENMAB A/S
Inventor： Rik RADEMAKER , Isil ALTINTAS , Patrick ENGELBERTS , Janine SCHUURMAN , Paul PARREN
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：US20210324105A1
公开(公告)日：2021-10-21
申请号：US17149019
申请日：2021-01-14
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Patrick VAN BERKEL , Kristin STRUMANE , Aran Frank LABRIJN , Joost J. NEIJSSEN , Joyce I. MEESTERS , Paul PARREN , Janine SCHUURMAN
Abstract: Bispecific antibodies which comprise antigen-binding regions binding to two different epitopes of human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods of preparing and using the antibodies are also disclosed.
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