公开(公告)号：US11547701B2

公开(公告)日：2023-01-10

申请号：US17018196

申请日：2020-09-11

Applicant: Valo Health, Inc. ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Alexandre J. Buckmelter ,  Karl H. Clodfelter ,  Peter Dragovich ,  Francis Gosselin ,  Bingsong Han ,  Jian Lin ,  Dominic J. Reynolds ,  Bruce Roth ,  Chase C. Smith ,  Zhongguo Wang ,  Po-Wai Yuen ,  Xiaozhang Zheng

IPC: C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/496 ,  A61K31/497 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D487/04 ,  C07D491/048

Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:

公开(公告)号：US11279687B2

公开(公告)日：2022-03-22

申请号：US16824885

申请日：2020-03-20

Applicant: Valo Health, Inc. ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Alexandre J. Buckmelter ,  Karl H. Clodfelter ,  Bingsong Han ,  Jian Lin ,  Dominic J. Reynolds ,  Chase C. Smith ,  Zhongguo Wang ,  Xiaozhang Zheng ,  Po-Wai Yuen

IPC: C07D401/12 ,  C07D213/74 ,  C07D213/75 ,  C07D213/81 ,  A61K31/4406 ,  C07C317/42 ,  C07D213/54 ,  C07D213/84 ,  C07D471/04 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4545 ,  A61K31/5377 ,  A61K45/06 ,  C07D213/40

Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.

公开(公告)号：US20210171545A1

公开(公告)日：2021-06-10

申请号：US16944581

申请日：2020-07-31

Applicant: Integral Early Discovery, Inc. ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Peter Dragovich ,  Xiongcai Liu ,  Snahel Patel ,  Po-Wai Yuen ,  Mark Zak ,  Guiling Zhao ,  Yamin Zhang ,  Xiaozhang Zheng

IPC: C07D519/00 ,  C07D495/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  A61K31/438 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/513

Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US10696692B2

公开(公告)日：2020-06-30

申请号：US14382141

申请日：2013-03-01

Applicant: Forma TM, LLC ,  Genentech, Inc.

Inventor： Kenneth W Bair ,  Timm R Baumeister ,  Alexandre J Buckmelter ,  Karl H Clodfelter ,  Peter Dragovich ,  Francis Gosselin ,  Janet Gunzner-Toste ,  Bingsong Han ,  Jian Lin ,  Xiongcai Liu ,  Dominic J Reynolds ,  Chase C Smith ,  Zhongguo Wang ,  Mark Zak ,  Yamin Zhang ,  Guiling Zhao ,  Xiaozhang Zheng ,  Po-Wai Yuen

IPC: A61K51/00 ,  A61M36/14 ,  C07D519/00 ,  C07D471/04 ,  C07D495/04 ,  C07D487/04 ,  C07D491/048 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/551 ,  A61K45/06

Abstract: The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US10647731B2

公开(公告)日：2020-05-12

申请号：US15962333

申请日：2018-04-25

Applicant: Genentech, Inc.

Inventor： Yu Jiang ,  Guosheng Wu ,  Po-Wai Yuen ,  Elisia Villemure ,  Jacob Schwarz ,  Cuong Ly ,  Benjamin Sellers ,  Matthew Volgraf

IPC: C07D513/14 ,  C07D513/04 ,  C07D513/10 ,  C07D519/00

Abstract: The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

公开(公告)号：US10456382B2

公开(公告)日：2019-10-29

申请号：US16212360

申请日：2018-12-06

Applicant: Forma TM, LLC ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Alexandre J. Buckmelter ,  Karl H. Clodfelter ,  Peter Dragovich ,  Francis Gosselin ,  Bingsong Han ,  Jian Lin ,  Dominic J. Reynolds ,  Bruce Roth ,  Chase C. Smith ,  Zhongguo Wang ,  Po-Wai Yuen ,  Xiaozhang Zheng

IPC: C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  A61K31/4355 ,  A61K31/496 ,  A61K31/437 ,  C07D491/04 ,  C07D495/04 ,  A61K31/4365 ,  A61K31/497 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06

Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:

公开(公告)号：US20190270721A1

公开(公告)日：2019-09-05

申请号：US16419333

申请日：2019-05-22

Applicant: Forma TM, LLC ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Alexandre J. Buckmelter ,  Karl H. Clodfelter ,  Bingsong Han ,  Jian Lin ,  Dominic J. Reynolds ,  Chase C. Smith ,  Zhongguo Wang ,  Xiaozhang Zheng ,  Po-Wai Yuen

IPC: C07D401/12 ,  C07D213/40 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4545 ,  A61K31/5377 ,  C07C317/42 ,  C07D471/04 ,  C07D213/84 ,  C07D213/81 ,  C07D213/75 ,  C07D213/74 ,  C07D213/54 ,  A61K45/06

Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.

公开(公告)号：US20180339998A1

公开(公告)日：2018-11-29

申请号：US15936086

申请日：2018-03-26

Applicant: Forma TM, LLC ,  Genentech, Inc.

Inventor： Kenneth W. Bair ,  Timm R. Baumeister ,  Peter Dragovich ,  Xiongcai Liu ,  Snahel Patel ,  Po-Wai Yuen ,  Mark Zak ,  Guiling Zhao ,  Yamin Zhang ,  Xiaozhang Zheng

IPC: C07D519/00 ,  A61K45/06 ,  C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/496 ,  A61K31/497 ,  A61K31/513 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/438 ,  C07D495/04 ,  C07D491/048 ,  C07D487/04 ,  A61K31/501

Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.