公开(公告)号：US20220162318A1

公开(公告)日：2022-05-26

申请号：US17547528

申请日：2021-12-10

Applicant: Genentech, Inc.

Inventor： Steven R. Leong ,  Andrew Polson ,  Paul Polakis ,  Yan Wu ,  Wei-Ching Liang ,  Ron Firestein

IPC: C07K16/28 ,  A61K47/65 ,  A61K47/68 ,  A61K38/08 ,  A61K39/395 ,  A61K51/10 ,  C07K16/30 ,  G01N33/569

Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US11286302B2

公开(公告)日：2022-03-29

申请号：US16043274

申请日：2018-07-24

Applicant: Genentech, Inc.

Inventor： Steven R. Leong ,  Andrew Polson ,  Paul Polakis ,  Yan Wu ,  Wei-Ching Liang ,  Ron Firestein

IPC: A61K47/68 ,  C07K16/28 ,  C07K16/30 ,  A61K31/404 ,  A61K31/5517 ,  A61K31/706 ,  A61K38/05 ,  G01N33/574 ,  A61K39/00

Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US11230600B2

公开(公告)日：2022-01-25

申请号：US16167000

申请日：2018-10-22

Applicant: Genentech, Inc.

Inventor： Steven R. Leong ,  Andrew Polson ,  Paul Polakis ,  Yan Wu ,  Wei-Ching Liang ,  Ron Firestein

IPC: C07K16/28 ,  A61K39/395 ,  A61K47/68 ,  G01N33/53 ,  A61K47/65 ,  A61K38/08 ,  A61K51/10 ,  C07K16/30 ,  G01N33/569 ,  A61K39/00

Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20190085089A1

公开(公告)日：2019-03-21

申请号：US16050936

申请日：2018-07-31

Applicant: Genentech, Inc.

Inventor： Jyoti Asundi ,  Ron Firestein ,  Paul Polakis ,  Chie Sakanaka ,  Peter Chang ,  Rayna Takaki Venook

IPC: C07K16/30 ,  G01N33/574 ,  A61K51/10 ,  A61K47/68 ,  A61K39/00

Abstract: The invention provides anti-Ly6E antibodies, immunoconjugates and methods of using the same.

公开(公告)号：US20190062432A1

公开(公告)日：2019-02-28

申请号：US16043274

申请日：2018-07-24

Applicant: Genentech, Inc.

Inventor： Steven R. Leong ,  Andrew Polson ,  Paul Polakis ,  Yan Wu ,  Wei-Ching Liang ,  Ron Firestein

IPC: C07K16/28 ,  G01N33/574 ,  C07K16/30 ,  A61K47/68 ,  A61K31/404 ,  A61K31/5517 ,  A61K31/706 ,  A61K38/05 ,  A61K39/00

Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US10066022B2

公开(公告)日：2018-09-04

申请号：US15018710

申请日：2016-02-08

Applicant: Genentech, Inc.

Inventor： Jyoti Asundi ,  Ron Firestein ,  Paul Polakis ,  Chie Sakanaka ,  Peter Chang ,  Rayna Takaki Venook

IPC: C07K16/30 ,  G01N33/574 ,  A61K51/10 ,  A61K47/68 ,  A61K39/00

CPC classification number: C07K16/30 ,  A61K47/6803 ,  A61K47/6851 ,  A61K51/1045 ,  A61K2039/505 ,  C07K2317/34 ,  G01N33/574 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57446 ,  G01N33/57449 ,  G01N33/57492 ,  G01N2333/705

Abstract: The invention provides anti-Ly6E antibodies, immunoconjugates and methods of using the same. In some embodiments, the anti-Ly6E antibodies comprise heavy chain HVRs comprising the amino acid sequences of SEQ ID NOs: 32-34 and/or light chain HVRs comprising the amino acid sequences of SEQ ID NOs: 29-31.