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公开(公告)号：US20200283478A1
公开(公告)日：2020-09-10
申请号：US16883552
申请日：2020-05-26
Applicant: Genentech, Inc.
Inventor： Maureen Beresini , Daniel Burdick , Charles Eigenbrot, Jr. , Daniel Kirchhofer , Robert Lazarus , Wei Li , John Quinn , Nicholas Skelton , Mark Ultsch , Yingnan Zhang
IPC: C07K7/02 , C12N9/64 , C12Q1/37 , G01N33/573 , G01N33/92 , C40B40/10 , C07K14/00 , A61K47/62 , A61P3/06
Abstract: The invention provides PCSK9 inhibitors, compositions comprising the PCSK9 inhibitors, and methods of identifying and using the PCSK9 inhibitors.
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公开(公告)号：US20190233441A1
公开(公告)日：2019-08-01
申请号：US16373435
申请日：2019-04-02
Applicant: Genentech, Inc.
Inventor： Nicholas C. Ray , Yun-Xing Cheng , Christine Edwards , Simon C. Goodacre , Wei Li , Snahel Patel , Matthew W. Cartwright , Mohammed Sajad , Po-wai Yuen , Mark E. Zak
IPC: C07D519/00 , C07D471/04
CPC classification number: C07D519/00 , C07D471/04
Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号：US20190177366A1
公开(公告)日：2019-06-13
申请号：US16229226
申请日：2018-12-21
Applicant: Genentech, Inc.
Inventor： Maureen Beresini , Daniel Burdick , Charles Eigenbrot, JR. , Daniel Kirchhofer , Robert Lazarus , Wei Li , John Quinn , Nicholas Skelton , Mark Ultsch , Yingnan Zhang
Abstract: The invention provides PCSK9 inhibitors, compositions comprising the PCSK9 inhibitors, and methods of identifying and using the PCSK9 inhibitors.
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公开(公告)号：US20190071404A1
公开(公告)日：2019-03-07
申请号：US16181228
申请日：2018-11-05
Applicant: Genentech, Inc.
Inventor： James John Crawford , Mark Zak , Terry Kellar , Yun-Xing Cheng , Wei Li , F. Anthony Romero , Paul Gibbons , Guiling Zhao , Gregory Hamilton , Simon Charles Goodacre
IPC: C07D231/40 , C07D401/04 , C07D405/04 , C07D403/08 , C07D409/14 , C07D401/14 , C07D405/12
Abstract: Compounds of Formula (I): and salts thereof, and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号：US10189836B2
公开(公告)日：2019-01-29
申请号：US16009596
申请日：2018-06-15
Applicant: Genentech, Inc.
Inventor： Yun-Xing Cheng , Rongbao Hua , Terry Kellar , Wei Li , Paul Gibbons , Mark Edward Zak
IPC: C07D471/04 , C07D519/00 , A61P11/06
Abstract: Compounds of Formula (I) and methods of use as Janus kinase inhibitors are described herein.
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Patent Agency Ranking
公开(公告)号：US09873709B2
公开(公告)日：2018-01-23
申请号：US15499662
申请日：2017-04-27
Applicant: Genentech, Inc.
Inventor： Nicholas C. Ray , Yun-Xing Cheng , Christine Edwards , Simon C. Goodacre , Wei Li , Snahel Patel , Matthew W. Cartwright , Mohammed Sajad , Po-wai Yuen , Mark E. Zak
IPC: C07D519/00 , C07D471/04
CPC classification number: C07D519/00 , C07D471/04
Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
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27.发明申请公开(公告)号：US20170145020A1
公开(公告)日：2017-05-25
申请号：US15424536
申请日：2017-02-03
Applicant: Genentech, Inc.
Inventor： Mark Edward Zak , Nicholas Charles Ray , Simon Charles Goodacre , Rohan Mendonca , Terry Kellar , Yun-Xing Cheng , Wei Li , Po-Wei Yuen
IPC: C07D487/04 , C07D519/00
CPC classification number: C07D471/04 , A61K31/519 , A61P11/06 , C07D403/14 , C07D487/04 , C07D519/00
Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号：US20180298033A1
公开(公告)日：2018-10-18
申请号：US15842642
申请日：2017-12-14
Applicant: Genentech, Inc.
Inventor： Nicholas C. Ray , Yun-Xing Cheng , Christine Edwards , Simon C. Goodacre , Wei Li , Snahel Patel , Matthew W. Cartwright , Mohammed Sajad , Po-wai Yuen , Mark E. Zak
IPC: C07D519/00 , C07D471/04
Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号：US20180086757A1
公开(公告)日：2018-03-29
申请号：US15692907
申请日：2017-08-31
Applicant: Genentech, Inc.
Inventor： Simon Charles Goodacre , Nicholas Charles Ray , Mark Edward Zak , Yun-Xing Cheng , Wei Li
IPC: C07D471/04 , C07D471/10
CPC classification number: C07D471/04 , C07D471/10
Abstract: Provided are triazolopyridine compounds that are inhibitors of JAK kinase, such as JAK1, compositions containing these compounds and methods for treating diseases mediated by a JAK kinase. In particular, provided are compounds of formula (I), stereoisomers, tautomers, solvates, prodrugs or pharmaceutically acceptable salts thereof, where R1a, R1b, R1c, R2, R3, R4 and R5 are defined herein, pharmaceutical compositions comprising the compound and a pharmaceutically acceptable carrier, adjuvant or vehicle, methods of using the compound or composition in therapy, for example, for treating a disease or condition mediated by a JAK kinase in a patient.
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30.发明申请5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF 有权5-氯二-2-二氟甲基苯基吡唑啉酮化合物，组合物及其使用方法公开(公告)号：US20150336962A1
公开(公告)日：2015-11-26
申请号：US14720323
申请日：2015-05-22
Applicant: Genentech, Inc.
Inventor： Mark Edward Zak , Nicholas Charles Ray , Simon Charles Goodacre , Rohan Mendonca , Terry Kellar , Yun-Xing Cheng , Wei Li , Po-Wai Yuen
IPC: C07D487/04 , C07D519/00
CPC classification number: C07D471/04 , A61K31/519 , C07D487/04 , C07D519/00
Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.
Abstract translation: 本文描述了式（00A）的化合物和用作Janus激酶抑制剂的方法。
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