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公开(公告)号：US20180215827A1
公开(公告)日：2018-08-02
申请号：US15832337
申请日：2017-12-05
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Simone DE HAIJ , Thilo RIEDL , Rene HOET , Ole BAADSGAARD , Jan VAN DE WINKEL , David SATIJN , Paul PARREN , Aran Frank LABRIJN , Joyce MEESTERS , Janine SCHUURMAN , Edward N. VAN DEN BRINK
CPC classification number: C07K16/2863 , A61K2039/505 , C07K16/2809 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/528 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US20160333095A1
公开(公告)日：2016-11-17
申请号：US15110414
申请日：2015-01-08
Applicant: GENMAB A/S
Inventor： Edward Norbert VAN DEN BRINK , Joost J. NEIJSSEN , Aran Frank LABRIJN , Joyce MEESTERS , Janine SCHUURMAN , Isil ALTINTAS , Paul PARREN , Rik RADEMAKER
CPC classification number: C07K16/2809 , A61K2039/505 , C07K16/1063 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/32 , C07K16/4241 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/74 , C07K2317/75 , C07K2317/90 , C07K2317/92 , G01N33/6872 , G01N2333/7051
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
Abstract translation: 本发明涉及结合CD3的人源化或嵌合抗体。 此外，它还涉及双特异性抗体，组合物，药物组合物，所述抗体在治疗疾病中的用途，以及治疗方法。
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公开(公告)号：US20160168247A1
公开(公告)日：2016-06-16
申请号：US14902757
申请日：2014-07-04
Applicant: GENMAB A/S
Inventor： Edward VAN DEN BRINK , Joost J. NEIJSSEN , Aran Frank LABRIJN , Joyce MEESTERS , Janine SCHUURMAN , Paul PARREN
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：US20210324105A1
公开(公告)日：2021-10-21
申请号：US17149019
申请日：2021-01-14
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Patrick VAN BERKEL , Kristin STRUMANE , Aran Frank LABRIJN , Joost J. NEIJSSEN , Joyce I. MEESTERS , Paul PARREN , Janine SCHUURMAN
Abstract: Bispecific antibodies which comprise antigen-binding regions binding to two different epitopes of human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods of preparing and using the antibodies are also disclosed.
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公开(公告)号：US20210155699A1
公开(公告)日：2021-05-27
申请号：US17099328
申请日：2020-11-16
Applicant: Genmab A/S
Inventor： Aran Frank LABRIJN , Stefan LOVERIX , Paul PARREN , Jan VAN DE WINKEL , Janine SCHUURMAN , Ignace LASTERS
IPC: C07K16/28 , C07K16/00 , A61K39/395 , A61K51/10 , A61K47/68
Abstract: The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.
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Patent Agency Ranking
公开(公告)号：US20200332022A1
公开(公告)日：2020-10-22
申请号：US16783720
申请日：2020-02-06
Applicant: GENMAB A/S
Inventor： Aran Frank LABRIJN , Joyce I. MEESTERS , Joost J. NEIJSSEN , Edward Norbert VAN DEN BRINK , Janine SCHUURMAN , Paul PARREN
Abstract: Described herein are, proteins comprising amino acid substitutions in at least one of a first and a second polypeptide chain. Furthermore, is described the uses and methods related to said proteins.
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公开(公告)号：US20170313782A1
公开(公告)日：2017-11-02
申请号：US15484583
申请日：2017-04-11
Applicant: GENMAB A/S
Inventor： Joost J. NEIJSSEN , Bart DE GOEIJ , Edward Norbert VAN DEN BRINK , Aran Frank LABRIJN , Rene HOET , Janine SCHUURMAN , Paul PARREN , Jan VAN DE WINKEL
IPC: C07K16/30 , A61K45/06 , C07K16/40 , A61K39/395 , G01N33/574 , C07K16/28 , A61K39/00
Abstract: Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US20160159930A1
公开(公告)日：2016-06-09
申请号：US14934956
申请日：2015-11-06
Applicant: GENMAB A/S
Inventor： Janine SCHUURMAN , Tom VINK , Jan VAN DE WINKEL , Aran Frank LABRIJN , Rob AALBERSE , Marijn VAN DER NEUT KOLFSCHOTE , Paul PARREN
CPC classification number: C07K16/468 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K2317/24 , C07K2317/31 , C07K2317/526 , C07K2317/53 , C07K2319/00
Abstract: The invention relates to an ex vivo method for the generation of a bispecific antibody, comprising the steps of: a) providing a first antibody having a first binding specificity, wherein said first antibody comprises an IgG4-like CH3 region, b) providing a second antibody having a second binding specificity which differs from said first binding specificity, wherein said second antibody comprises an IgG4-like CH3 region, c) incubating said first and second antibodies together under reducing conditions which allow the cysteines in the core hinge region to undergo disulfide-bond isomerization, and d) obtaining a bispecific antibody. The invention furthermore relates to bispecific antibodies obtainable by the method of the invention.
Abstract translation: 本发明涉及用于产生双特异性抗体的离体方法，包括以下步骤：a）提供具有第一结合特异性的第一抗体，其中所述第一抗体包含IgG4样CH3区，b）提供第二抗体 具有不同于所述第一结合特异性的第二结合特异性的抗体，其中所述第二抗体包含IgG4样CH3区，c）在还原条件下将所述第一抗体和第二抗体一起温育，所述还原条件允许核心铰链区中的半胱氨酸经历二硫键 并且d）获得双特异性抗体。 本发明还涉及通过本发明的方法可获得的双特异性抗体。
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公开(公告)号：US20150329642A1
公开(公告)日：2015-11-19
申请号：US14721709
申请日：2015-05-26
Applicant: GENMAB A/S
Inventor： Joost J. NEIJSSEN , Bart DE GOEIJ , Edward Norbert VAN DEN BRINK , Aran Frank LABRIJN , Rene HOET , Janine SCHUURMAN , Paul PARREN , Jan VAN DE WINKEL
IPC: C07K16/30 , G01N33/574
CPC classification number: C07K16/3076 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/71 , C07K2317/74 , C07K2317/76 , C07K2317/92 , G01N33/5748 , G01N2333/912
Abstract: Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
Abstract translation: 公开了结合人c-Met，肝细胞生长因子受体以及相关的基于抗体的组合物和分子的分离的单克隆抗体。 还公开了包含抗体的药物组合物和使用抗体的治疗和诊断方法。
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公开(公告)号：US20150004177A1
公开(公告)日：2015-01-01
申请号：US14317600
申请日：2014-06-27
Applicant: GENMAB A/S
Inventor： Edward Norbert VAN DEN BRINK , Paul PARREN , Jan VAN DE WINKEL , Aran Frank LABRIJN , Frank Everhardus Martinus REBERS , Esther Cornelia Wilhelmina BREIJ
IPC: C07K16/28
CPC classification number: C07K16/283 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/92
Abstract: Isolated monoclonal antibodies which bind to human CD32b and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
Abstract translation: 公开了与人CD32b和相关的基于抗体的组合物和分子结合的分离的单克隆抗体。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
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