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35 条记录 (耗时 0.038 秒)

    New thiophene compounds as intermediates
    21.
    发明授权
    New thiophene compounds as intermediates 失效
    新噻吩化合物作为中间体

    公开(公告)号：US5175294A

    公开(公告)日：1992-12-29

    申请号：US740075

    申请日：1991-08-05

    申请人： Michel Wierzbicki ,  Frederic Sauveur ,  Jacqueline Bonnet ,  Martine Brisset ,  Charles Tordjman

    发明人： Michel Wierzbicki ,  Frederic Sauveur ,  Jacqueline Bonnet ,  Martine Brisset ,  Charles Tordjman

    IPC分类号： C07D333/20 ,  C07D333/24

    CPC分类号： C07D333/20 ,  C07D333/24

    摘要： New thiophene compounds of the formula: ##STR1## in which: X represents hydrogen, halogen, C.sub.1 -C.sub.5 alkyl or alkoxy or dialkylamino;n represents 1 or 2;a represents an integer of from 2 to 6;b represents 2 or 3;c represents 1 or 2, and is such that b+c=4;R.sub.1 and R.sub.2 represent hydrogen or (C.sub.1 -C.sub.5)alkyl, or together with the carbon atom to which they are bonded form a hydrocarbon ring containing from 3 to 6 carbon atoms; andR and R' represent hydrogen or (C.sub.1 -C.sub.5)alkyl, or together with the nitrogen atom to which they are bonded form a pentagonal or hexagonal heterocycle optionally containing an oxygen atom or a second nitrogen atom which may itself be substituted; and their physiologically tolerable salts.The products of the invention can be used therapeutically especially in the treatment of pathologies that are characterized by a loss of bone tissue.As new intermediate products used in the synthesis of the compounds I above defined, the amides of the formula: ##STR2## in which: X, n, a, b, c, R.sub.1, R.sub.2, R and R' are as above defined.

    摘要翻译： 新的具有下式的噻吩化合物：其中：X表示氢，卤素，C 1 -C 5烷基或烷氧基或二烷基氨基; n表示1或2; a表示2〜6的整数， b表示2或3; c表示1或2，并且b + c = 4; R1和R2表示氢或（C1-C5）烷基，或与它们所键合的碳原子一起形成含有3至6个碳原子的烃环; 并且R和R'表示氢或（C1-C5）烷基，或与它们所键合的氮原子一起形成任选地含有氧原子的五价或六价杂环或本身可被取代的第二氮原子; 及其生理上可耐受的盐。 本发明的产品可以治疗特别用于治疗以组织损失为特征的病理学。 作为上述化合物I的合成中使用的新的中间产物，下式的酰胺如下：其中：X，n，a，b，c，R 1，R 2，R和R'如上所定义。

    Piperidine compounds
    26.
    发明授权
    Piperidine compounds 失效
    哌啶化合物

    公开(公告)号：US5652246A

    公开(公告)日：1997-07-29

    申请号：US546263

    申请日：1995-10-20

    申请人： Guillaume de Nanteuil ,  Georges Remond ,  Bernard Portevin ,  Jacqueline Bonnet ,  Emmanuel Canet ,  Graham Birrell

    发明人： Guillaume de Nanteuil ,  Georges Remond ,  Bernard Portevin ,  Jacqueline Bonnet ,  Emmanuel Canet ,  Graham Birrell

    IPC分类号： A61K31/4427 ,  A61K31/445 ,  A61P1/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D401/06 ,  C07D471/04 ,  C07D471/02 ,  A61K31/415 ,  A61K31/44 ,  C07D235/22

    CPC分类号： C07D401/06 ,  C07D471/04

    摘要： The invention relates to the compounds of formula (I): ##STR1## in which: R.sub.1 represents alkyl, phenyl, naphthyl, pyridyl or thienyl group, each phenyl, naphthyl, pyridyl or thienyl optionally being substituted,R.sub.2 represents a hydrogen atom or a substituted or unsubstituted alkyl, substituted or unsubstituted phenyl, cycloalkyl, piperidino or substituted or unsubstituted amino group,X represents CO or SO.sub.2,R.sub.3 represents hydrogen or alkyl,R.sub.4 represents alkyl, substituted or unsubstituted phenyl or trihalomethyl, or else R.sub.3 and R.sub.4 form, together with the carbon atoms which carry them, cyclo(C.sub.3 -C.sub.7)alkenyl,A represents phenyl, naphthyl or pyridyl ring, each phenyl, naphthyl or pyridyl ring optionally being substituted,their isomers, the corresponding quaternary ammonium salts of the piperidine and their addition salts with a pharmaceutically acceptable acid, an medicinal products containing the same are useful as antagonists of NK.sub.1 receptors.

    摘要翻译： 本发明涉及式（I）化合物：其中：R 1表示烷基，苯基，萘基，吡啶基或噻吩基，每个苯基，萘基，吡啶基或噻吩基任选被取代，R 2表示氢 原子或取代或未取代的烷基，取代或未取代的苯基，环烷基，哌啶子基或取代或未取代的氨基，X表示CO或SO 2，R 3表示氢或烷基，R 4表示烷基，取代或未取代的苯基或三卤甲基， R 4与携带它们的碳原子一起形成环（C 3 -C 7）链烯基，A代表苯基，萘基或吡啶环，每个苯基，萘基或吡啶基任选被取代，它们的异构体是相应的季铵盐 哌啶及其与药学上可接受的酸的加成盐，含有它们的药物可用作NK1受体的拮抗剂。

    4-methyl-5-substituted-1,3-oxazoles having anti-inflammatory activity
    27.
    发明授权
    4-methyl-5-substituted-1,3-oxazoles having anti-inflammatory activity 失效
    具有抗炎活性的4-甲基-5-取代-1,3-恶唑

    公开(公告)号：US5468761A

    公开(公告)日：1995-11-21

    申请号：US164464

    申请日：1993-12-09

    申请人： Guillaume de Nanteuil ,  Michel Vincent ,  Christine Lila ,  Jacqueline Bonnet ,  Armel Fradin

    发明人： Guillaume de Nanteuil ,  Michel Vincent ,  Christine Lila ,  Jacqueline Bonnet ,  Armel Fradin

    IPC分类号： A61K31/42 ,  A61K31/421 ,  A61P29/00 ,  C07D263/32

    CPC分类号： C07D263/32 ,  A61K31/42

    摘要： Compound of formula (I): ##STR1## in which: R.sub.1 represents 1-adamantyl, dicyclopropylmethyl, substituted or unsubstituted (C.sub.3 -C.sub.6) cycloalkyl or substituted or unsubstituted bicyclo[2.2.2]oct-1-yl,R.sub.2 represents: ##STR2## in which: m represents 1, 2 or 3,X represents oxygen or sulfur or N--R,R.sub.3 or R.sub.4, which are identical or different, represent hydrogen, (C.sub.1 -C.sub.6) alkyl or trifluoromethyl, ##STR3## n represents 0, 1 or 2, R.sub.5 represents hydroxy, or (C.sub.1 -C.sub.6) alkoxy, and anti-inflammatory medicinal products containing the same.

    摘要翻译： 式（I）化合物：其中：R1表示1-金刚烷基，二环丙基甲基，取代或未取代的（C3-C6）环烷基或取代或未取代的双环[2.2.2]辛-1-基，R2 表示： 其中：m表示1,2或3，X表示氧或硫或NR，R3或R4相同或不同，表示氢，（C1-C6）烷基或三氟甲基， IMAGE> n表示0,1或2，R 5表示羟基或（C 1 -C 6）烷氧基，和含有它们的抗炎药物。

    Pharmaceutical compositions having immuno-suppressive properties
    28.
    发明授权
    Pharmaceutical compositions having immuno-suppressive properties 失效
    具有免疫抑制特性的药物组合物

    公开(公告)号：US4617315A

    公开(公告)日：1986-10-14

    申请号：US738043

    申请日：1985-05-24

    申请人： Pierre Bessin ,  Jacqueline Bonnet

    发明人： Pierre Bessin ,  Jacqueline Bonnet

    IPC分类号： A61K31/40 ,  A61P37/00 ,  A61P37/06 ,  C07D207/34

    CPC分类号： A61K31/40 ,  C07D207/34

    摘要： This invention relates to novel pharmaceutical compositions having immuno-suppressive activities, the active ingredient of which is a 4-aroyl N-alkyl or aryl pyrrolyl-2 carboxylic acid or a salt thereof.The pharmaceutical compositions have therapeutic utility for treating auto-immune diseases, or in the prevention of rejection of graft organs.

    摘要翻译： 本发明涉及具有免疫抑制活性的新型药物组合物，其活性成分是4-芳酰基N-烷基或芳基吡咯基-2-羧酸或其盐。 该药物组合物具有治疗自身免疫疾病或预防移植器官排斥的治疗效用。

    2-Methyl-2-phenoxy-propionic acid derivatives, process for their preparation and therapeutical applications thereof
    29.
    发明授权
    2-Methyl-2-phenoxy-propionic acid derivatives, process for their preparation and therapeutical applications thereof 失效
    2-甲基-2-苯氧基 - 丙酸衍生物，其制备方法及其治疗应用

    公开(公告)号：US4259509A

    公开(公告)日：1981-03-31

    申请号：US874479

    申请日：1978-02-02

    申请人： Jacqueline Laforest ,  Jacqueline Bonnet ,  Pierre Bessin

    发明人： Jacqueline Laforest ,  Jacqueline Bonnet ,  Pierre Bessin

    IPC分类号： A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61P3/06 ,  A61P19/06 ,  C07D307/52 ,  C07D307/56 ,  C07D333/22

    CPC分类号： C07D333/22 ,  C07D307/52

    摘要： This invention relates to compounds having the formula: ##STR1## which represents the isomer Z, the isomer E or the mixture of both stereoisomers of the oximino group and in which:A represents O or S,X.sup.1 represents a halogen atom, a hydrogen atom or a methyl group,R represents a hydrogen atom or a C.sub.1-5 alkyl group,X.sup.2 and X.sup.3, which may be the same or different, represent each a hydrogen atom, a halogen atom or a C.sub.1-5 alkyl group, andR' represents a hydrogen atom or a C.sub.1-5 alkyl group, andthe group ##STR2## is at 2- or 3-position on the heterocycle, and the salts of acids of the formula (I) with physiologically acceptable bases, and the compounds which are metabolically converted to compounds of the formula (I).Said compounds are therapeutically useful, typically as hypocholesterolemic, hypolipemic and uricosuric agents.

    摘要翻译： 本发明涉及具有下式的化合物：表示异构体Z，异构体E或肟基的两种立体异构体的混合物，其中：A表示O或S，X 1表示卤素原子， 氢原子或甲基，R表示氢原子或C1-5烷基，X2和X3可以相同或不同，表示氢原子，卤素原子或C1-5烷基， 并且R'表示氢原子或C 1-5烷基，并且基团在杂环上的2-或3-位，式（I）的酸与生理上可接受的碱的盐，以及 代谢转化为式（I）化合物的化合物。 所述化合物在治疗上是有用的，通常为低胆固醇血症，降血糖和尿酸血症。

    SYSTEMS AND METHODS FOR MANAGING HOSPITALITY FACILITIES
    30.
    发明申请
    SYSTEMS AND METHODS FOR MANAGING HOSPITALITY FACILITIES 审中-公开
    管理医院设施的系统和方法

    公开(公告)号：US20120278090A1

    公开(公告)日：2012-11-01

    申请号：US13096482

    申请日：2011-04-28

    申请人： Daniel R. Frankfort ,  Fernando J. Rosario ,  Jacqueline Bonnet ,  Malcolm A. McNamara

    发明人： Daniel R. Frankfort ,  Fernando J. Rosario ,  Jacqueline Bonnet ,  Malcolm A. McNamara

    IPC分类号： G06Q10/00

    CPC分类号： G06Q10/06

    摘要： Systems and methods are provided for managing a plurality of hospitality facilities. A property management component and an external component are located remotely from the plurality of hospitality facilities. The property management component is integrated with the external component to provide hospitality services at the plurality of hospitality facilities. The external component includes a loyalty component that interacts with the integrated system for providing a user with access to the hospitality services e.g., purchasing, at one of the plurality of hospitality facilities.

    摘要翻译： 提供了用于管理多个酒店设施的系统和方法。 物业管理部件和外部部件远离多个酒店设施。 物业管理部门与外部组件结合，在多个酒店设施提供酒店服务。 外部组件包括与集成系统交互的忠诚度组件，以向用户提供对接待服务的访问，例如在多个酒店设施中的一个处购买。